Abstract
A mouse monoclonal antibody, HAV 4-1, obtained after immunization of a BALB/c mouse with purified C3F, detected a novel genetic polymorphism of human complement component C3 in a simple immunoblotting system. The frequency of HAV 4-1-positive genes was 20.1%. Reactivity of HAV 4-1 was closely related to C3F, but certain individuals with the C3F allele did not react with HAV 4-1. Conversely, certain C3S homozygous individuals did react with HAV 4-1. The polymorphism detected by this monoclonal antibody is therefore different from the previously described polymorphism based on charge differences.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Immunogenetics |
| Vol/bind | 23 |
| Udgave nummer | 5 |
| Sider (fra-til) | 322-5 |
| Antal sider | 4 |
| ISSN | 0093-7711 |
| Status | Udgivet - 1986 |
| Udgivet eksternt | Ja |