A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ

Alfred L Nuttall; Anthony J Ricci; George Burwood; James M Harte; Stefan Stenfelt; Per Cayé-Thomasen; Tianying Ren; Sripriya Ramamoorthy; Yuan Zhang; Teresa Wilson; Thomas Lunner; Brian C J Moore; Anders Fridberger

doi:10.1038/s41467-018-06725-w

A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ

Alfred L Nuttall, Anthony J Ricci, George Burwood, James M Harte, Stefan Stenfelt, Per Cayé-Thomasen, Tianying Ren, Sripriya Ramamoorthy, Yuan Zhang, Teresa Wilson, Thomas Lunner, Brian C J Moore, Anders Fridberger

Institut for Klinisk Medicin

10 Citationer (Scopus)

33 Downloads (Pure)

Abstract

To understand speech, the slowly varying outline, or envelope, of the acoustic stimulus is used to distinguish words. A small amount of information about the envelope is sufficient for speech recognition, but the mechanism used by the auditory system to extract the envelope is not known. Several different theories have been proposed, including envelope detection by auditory nerve dendrites as well as various mechanisms involving the sensory hair cells. We used recordings from human and animal inner ears to show that the dominant mechanism for envelope detection is distortion introduced by mechanoelectrical transduction channels. This electrical distortion, which is not apparent in the sound-evoked vibrations of the basilar membrane, tracks the envelope, excites the auditory nerve, and transmits information about the shape of the envelope to the brain.

Originalsprog	Engelsk
Artikelnummer	4175
Tidsskrift	Nature Communications
Vol/bind	9
Antal sider	11
ISSN	2041-1723
DOI	https://doi.org/10.1038/s41467-018-06725-w
Status	Udgivet - 1 dec. 2018

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10.1038/s41467-018-06725-wLicens: CC BY

s41467-018-06725-wForlagets udgivne version, 2,33 MBLicens: CC BY

Citationsformater

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title = "A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ",

abstract = "To understand speech, the slowly varying outline, or envelope, of the acoustic stimulus is used to distinguish words. A small amount of information about the envelope is sufficient for speech recognition, but the mechanism used by the auditory system to extract the envelope is not known. Several different theories have been proposed, including envelope detection by auditory nerve dendrites as well as various mechanisms involving the sensory hair cells. We used recordings from human and animal inner ears to show that the dominant mechanism for envelope detection is distortion introduced by mechanoelectrical transduction channels. This electrical distortion, which is not apparent in the sound-evoked vibrations of the basilar membrane, tracks the envelope, excites the auditory nerve, and transmits information about the shape of the envelope to the brain.",

keywords = "Acoustic Stimulation, Adult, Animals, Basilar Membrane/physiology, Biomechanical Phenomena, Cochlea/physiology, Electricity, Female, Hearing/physiology, Humans, Male, Middle Aged, Organ of Corti/physiology, Rats, Sound",

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T1 - A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ

AU - Nuttall, Alfred L

AU - Ricci, Anthony J

AU - Burwood, George

AU - Harte, James M

AU - Stenfelt, Stefan

AU - Cayé-Thomasen, Per

AU - Ren, Tianying

AU - Ramamoorthy, Sripriya

AU - Zhang, Yuan

AU - Wilson, Teresa

AU - Lunner, Thomas

AU - Moore, Brian C J

AU - Fridberger, Anders

PY - 2018/12/1

Y1 - 2018/12/1

N2 - To understand speech, the slowly varying outline, or envelope, of the acoustic stimulus is used to distinguish words. A small amount of information about the envelope is sufficient for speech recognition, but the mechanism used by the auditory system to extract the envelope is not known. Several different theories have been proposed, including envelope detection by auditory nerve dendrites as well as various mechanisms involving the sensory hair cells. We used recordings from human and animal inner ears to show that the dominant mechanism for envelope detection is distortion introduced by mechanoelectrical transduction channels. This electrical distortion, which is not apparent in the sound-evoked vibrations of the basilar membrane, tracks the envelope, excites the auditory nerve, and transmits information about the shape of the envelope to the brain.

AB - To understand speech, the slowly varying outline, or envelope, of the acoustic stimulus is used to distinguish words. A small amount of information about the envelope is sufficient for speech recognition, but the mechanism used by the auditory system to extract the envelope is not known. Several different theories have been proposed, including envelope detection by auditory nerve dendrites as well as various mechanisms involving the sensory hair cells. We used recordings from human and animal inner ears to show that the dominant mechanism for envelope detection is distortion introduced by mechanoelectrical transduction channels. This electrical distortion, which is not apparent in the sound-evoked vibrations of the basilar membrane, tracks the envelope, excites the auditory nerve, and transmits information about the shape of the envelope to the brain.

KW - Acoustic Stimulation

KW - Adult

KW - Animals

KW - Basilar Membrane/physiology

KW - Biomechanical Phenomena

KW - Cochlea/physiology

KW - Electricity

KW - Female

KW - Hearing/physiology

KW - Humans

KW - Male

KW - Middle Aged

KW - Organ of Corti/physiology

KW - Rats

KW - Sound

U2 - 10.1038/s41467-018-06725-w

DO - 10.1038/s41467-018-06725-w

M3 - Journal article

C2 - 30302006

SN - 2041-1723

VL - 9

JO - Nature Communications

JF - Nature Communications

M1 - 4175

ER -

A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ

Abstract

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