A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

Andrés Ingason; Ina Giegling; Sven Cichon; Thomas Hansen; Henrik B Rasmussen; Jimmi Nielsen; Gesche Jürgens; Pierandrea Muglia; Annette M Hartmann; Eric Strengman; Catalina Vasilescu; Thomas W Mühleisen; Srdjan Djurovic; Ingrid Melle; Bernard Lerer; Hans-Jürgen Möller; Clyde Francks; Olli P H Pietiläinen; Jouko Lonnqvist; Jaana Suvisaari; Annamari Tuulio-Henriksson; Muriel Walshe; Evangelos Vassos; Marta Di Forti; Robin Murray; Chiara Bonetto; Sarah Tosato; Rita M Cantor; Marcella Rietschel; Nick Craddock; Michael J Owen; Leena Peltonen; Ole A Andreassen; Markus M Nöthen; David St Clair; Roel A Ophoff; Michael C O'Donovan; David A Collier; Thomas Werge; Dan Rujescu; GROUP Investigators

doi:10.1093/hmg/ddq009

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

Andrés Ingason, Ina Giegling, Sven Cichon, Thomas Hansen, Henrik B Rasmussen, Jimmi Nielsen, Gesche Jürgens, Pierandrea Muglia, Annette M Hartmann, Eric Strengman, Catalina Vasilescu, Thomas W Mühleisen, Srdjan Djurovic, Ingrid Melle, Bernard Lerer, Hans-Jürgen Möller, Clyde Francks, Olli P H Pietiläinen, Jouko Lonnqvist, Jaana SuvisaariAnnamari Tuulio-Henriksson, Muriel Walshe, Evangelos Vassos, Marta Di Forti, Robin Murray, Chiara Bonetto, Sarah Tosato, Rita M Cantor, Marcella Rietschel, Nick Craddock, Michael J Owen, Leena Peltonen, Ole A Andreassen, Markus M Nöthen, David St Clair, Roel A Ophoff, Michael C O'Donovan, David A Collier, Thomas Werge, Dan Rujescu, GROUP Investigators

38 Citationer (Scopus)

Abstract

The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 × 10^-5-1.7 × 10^-3,common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

Originalsprog	Engelsk
Tidsskrift	Human Molecular Genetics
Vol/bind	19
Udgave nummer	7
Sider (fra-til)	1379-86
Antal sider	8
ISSN	0964-6906
DOI	https://doi.org/10.1093/hmg/ddq009
Status	Udgivet - 12 jan. 2010

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10.1093/hmg/ddq009

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Ingason, A., Giegling, I., Cichon, S., Hansen, T., Rasmussen, H. B., Nielsen, J., Jürgens, G., Muglia, P., Hartmann, A. M., Strengman, E., Vasilescu, C., Mühleisen, T. W., Djurovic, S., Melle, I., Lerer, B., Möller, H-J., Francks, C., Pietiläinen, O. P. H., Lonnqvist, J., ... GROUP Investigators (2010). A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia. Human Molecular Genetics, 19(7), 1379-86. https://doi.org/10.1093/hmg/ddq009

Ingason, A, Giegling, I, Cichon, S, Hansen, T , Rasmussen, HB, Nielsen, J, Jürgens, G, Muglia, P, Hartmann, AM, Strengman, E, Vasilescu, C, Mühleisen, TW, Djurovic, S, Melle, I, Lerer, B, Möller, H-J, Francks, C, Pietiläinen, OPH, Lonnqvist, J, Suvisaari, J, Tuulio-Henriksson, A, Walshe, M, Vassos, E, Di Forti, M, Murray, R, Bonetto, C, Tosato, S, Cantor, RM, Rietschel, M, Craddock, N, Owen, MJ, Peltonen, L, Andreassen, OA, Nöthen, MM, St Clair, D, Ophoff, RA, O'Donovan, MC, Collier, DA, Werge, T, Rujescu, D & GROUP Investigators 2010, 'A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia', Human Molecular Genetics, bind 19, nr. 7, s. 1379-86. https://doi.org/10.1093/hmg/ddq009

@article{bed8c4c3f7994458b6256482fc15f97a,

title = "A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia",

abstract = "The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 × 10-5-1.7 × 10-3,common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.",

author = "Andr{\'e}s Ingason and Ina Giegling and Sven Cichon and Thomas Hansen and Rasmussen, {Henrik B} and Jimmi Nielsen and Gesche J{\"u}rgens and Pierandrea Muglia and Hartmann, {Annette M} and Eric Strengman and Catalina Vasilescu and M{\"u}hleisen, {Thomas W} and Srdjan Djurovic and Ingrid Melle and Bernard Lerer and Hans-J{\"u}rgen M{\"o}ller and Clyde Francks and Pietil{\"a}inen, {Olli P H} and Jouko Lonnqvist and Jaana Suvisaari and Annamari Tuulio-Henriksson and Muriel Walshe and Evangelos Vassos and {Di Forti}, Marta and Robin Murray and Chiara Bonetto and Sarah Tosato and Cantor, {Rita M} and Marcella Rietschel and Nick Craddock and Owen, {Michael J} and Leena Peltonen and Andreassen, {Ole A} and N{\"o}then, {Markus M} and {St Clair}, David and Ophoff, {Roel A} and O'Donovan, {Michael C} and Collier, {David A} and Thomas Werge and Dan Rujescu and Thomas Werge",

year = "2010",

month = jan,

day = "12",

doi = "10.1093/hmg/ddq009",

language = "English",

volume = "19",

pages = "1379--86",

journal = "Human Molecular Genetics",

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TY - JOUR

T1 - A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

AU - Ingason, Andrés

AU - Giegling, Ina

AU - Cichon, Sven

AU - Hansen, Thomas

AU - Rasmussen, Henrik B

AU - Nielsen, Jimmi

AU - Jürgens, Gesche

AU - Muglia, Pierandrea

AU - Hartmann, Annette M

AU - Strengman, Eric

AU - Vasilescu, Catalina

AU - Mühleisen, Thomas W

AU - Djurovic, Srdjan

AU - Melle, Ingrid

AU - Lerer, Bernard

AU - Möller, Hans-Jürgen

AU - Francks, Clyde

AU - Pietiläinen, Olli P H

AU - Lonnqvist, Jouko

AU - Suvisaari, Jaana

AU - Tuulio-Henriksson, Annamari

AU - Walshe, Muriel

AU - Vassos, Evangelos

AU - Di Forti, Marta

AU - Murray, Robin

AU - Bonetto, Chiara

AU - Tosato, Sarah

AU - Cantor, Rita M

AU - Rietschel, Marcella

AU - Craddock, Nick

AU - Owen, Michael J

AU - Peltonen, Leena

AU - Andreassen, Ole A

AU - Nöthen, Markus M

AU - St Clair, David

AU - Ophoff, Roel A

AU - O'Donovan, Michael C

AU - Collier, David A

AU - Werge, Thomas

AU - Rujescu, Dan

AU - GROUP Investigators

PY - 2010/1/12

Y1 - 2010/1/12

N2 - The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 × 10-5-1.7 × 10-3,common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

AB - The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18 920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 × 10-5-1.7 × 10-3,common OR = 1.09-1.11). The region contains two genes, AHI1and C6orf217, and both genes-as well as the neighbouring phosphodiesterase 7B (PDE7B)-may be considered candidates for involvement in the genetic aetiology of schizophrenia.

U2 - 10.1093/hmg/ddq009

DO - 10.1093/hmg/ddq009

M3 - Journal article

C2 - 20071346

SN - 0964-6906

VL - 19

SP - 1379

EP - 1386

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 7

ER -

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia

Abstract

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