A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale

Armida Mucci; Annarita Vignapiano; István Bitter; Stephen F. Austin; Camille Delouche; Sonia Dollfus; Andreas Erfurth; W. Wolfgang Fleischhacker; Giulia M. Giordano; Igor Gladyshev; Birte Glenthøj; Karoline Gütter; Alex Hofer; Jan Hubeňák; Stefan Kaiser; Jan Libiger; Ingrid Melle; Mette Ø. Nielsen; Oleg Papsuev; Janusz K. Rybakowski; Gabriele Sachs; Alp Üçok; Pawel Wojciak; Silvana Galderisi

doi:10.1016/j.euroneuro.2019.05.006

A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale

Armida Mucci^*, Annarita Vignapiano, István Bitter, Stephen F. Austin, Camille Delouche, Sonia Dollfus, Andreas Erfurth, W. Wolfgang Fleischhacker, Giulia M. Giordano, Igor Gladyshev, Birte Glenthøj, Karoline Gütter, Alex Hofer, Jan Hubeňák, Stefan Kaiser, Jan Libiger, Ingrid Melle, Mette Ø. Nielsen, Oleg Papsuev, Janusz K. RybakowskiGabriele Sachs, Alp Üçok, Pawel Wojciak, Silvana Galderisi

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

17 Citationer (Scopus)

2 Downloads (Pure)

Abstract

Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the consensus are available, studies still rely upon old assessment instruments, that do not reflect recent conceptualizations and might limit progress in the search for effective treatments. This is often the case in the European context, where one of the challenges encountered in designing large studies is the availability of validated instruments in the many languages of the continent. To address this challenge and promote sound research on negative symptoms in Europe, the ECNP Schizophrenia Network coordinated a large multicenter, multinational validation study of the Brief Negative Symptom Scale (BNSS). Clinically-stable subjects with schizophrenia (SCZ, N = 249) were recruited from 10 European Countries. Apart from BNSS, subjects were administered the Positive and Negative Syndrome Scale (PANSS) and standardized instruments for depression, extrapyramidal symptoms and psychosocial functioning. Results showed an excellent internal consistency, convergent and discriminant validity of BNSS and replicated a 5 factor-model. A larger number of subjects with predominant negative symptoms, i.e. the target population for clinical trials, was identified by using the BNSS compared to the PANSS. Regression analysis showed that BNSS-avolition, a key negative symptom poorly assessed by PANSS, explained 23.9% of psychosocial functioning, while no combination of the PANSS core negative symptoms showed the same impact on functioning. The study demonstrated that BNSS has substantial advantages with respect to PANSS for the identification of the avolition domain and subjects with predominant negative symptoms.

Originalsprog	Engelsk
Tidsskrift	European Neuropsychopharmacology
Vol/bind	29
Udgave nummer	8
Sider (fra-til)	947-959
Antal sider	13
ISSN	0924-977X
DOI	https://doi.org/10.1016/j.euroneuro.2019.05.006
Status	Udgivet - 2019

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10.1016/j.euroneuro.2019.05.006Licens: CC BY-NC-ND

A large European, multicenter, multinational validation study of the Brief Negative Symptom ScaleForlagets udgivne version, 478 KBLicens: CC BY-NC-ND

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Mucci, A., Vignapiano, A., Bitter, I., Austin, S. F., Delouche, C., Dollfus, S., Erfurth, A., Fleischhacker, W. W., Giordano, G. M., Gladyshev, I., Glenthøj, B., Gütter, K., Hofer, A., Hubeňák, J., Kaiser, S., Libiger, J., Melle, I., Nielsen, M. Ø., Papsuev, O., ... Galderisi, S. (2019). A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale. European Neuropsychopharmacology, 29(8), 947-959. https://doi.org/10.1016/j.euroneuro.2019.05.006

Mucci, A, Vignapiano, A, Bitter, I, Austin, SF, Delouche, C, Dollfus, S, Erfurth, A, Fleischhacker, WW, Giordano, GM, Gladyshev, I, Glenthøj, B, Gütter, K, Hofer, A, Hubeňák, J, Kaiser, S, Libiger, J, Melle, I, Nielsen, MØ, Papsuev, O, Rybakowski, JK, Sachs, G, Üçok, A, Wojciak, P & Galderisi, S 2019, 'A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale', European Neuropsychopharmacology, bind 29, nr. 8, s. 947-959. https://doi.org/10.1016/j.euroneuro.2019.05.006

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title = "A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale",

abstract = "Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the consensus are available, studies still rely upon old assessment instruments, that do not reflect recent conceptualizations and might limit progress in the search for effective treatments. This is often the case in the European context, where one of the challenges encountered in designing large studies is the availability of validated instruments in the many languages of the continent. To address this challenge and promote sound research on negative symptoms in Europe, the ECNP Schizophrenia Network coordinated a large multicenter, multinational validation study of the Brief Negative Symptom Scale (BNSS). Clinically-stable subjects with schizophrenia (SCZ, N = 249) were recruited from 10 European Countries. Apart from BNSS, subjects were administered the Positive and Negative Syndrome Scale (PANSS) and standardized instruments for depression, extrapyramidal symptoms and psychosocial functioning. Results showed an excellent internal consistency, convergent and discriminant validity of BNSS and replicated a 5 factor-model. A larger number of subjects with predominant negative symptoms, i.e. the target population for clinical trials, was identified by using the BNSS compared to the PANSS. Regression analysis showed that BNSS-avolition, a key negative symptom poorly assessed by PANSS, explained 23.9% of psychosocial functioning, while no combination of the PANSS core negative symptoms showed the same impact on functioning. The study demonstrated that BNSS has substantial advantages with respect to PANSS for the identification of the avolition domain and subjects with predominant negative symptoms.",

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author = "Armida Mucci and Annarita Vignapiano and Istv{\'a}n Bitter and Austin, {Stephen F.} and Camille Delouche and Sonia Dollfus and Andreas Erfurth and Fleischhacker, {W. Wolfgang} and Giordano, {Giulia M.} and Igor Gladyshev and Birte Glenth{\o}j and Karoline G{\"u}tter and Alex Hofer and Jan Hube{\v n}{\'a}k and Stefan Kaiser and Jan Libiger and Ingrid Melle and Nielsen, {Mette {\O}.} and Oleg Papsuev and Rybakowski, {Janusz K.} and Gabriele Sachs and Alp {\"U}{\c c}ok and Pawel Wojciak and Silvana Galderisi",

year = "2019",

doi = "10.1016/j.euroneuro.2019.05.006",

language = "English",

volume = "29",

pages = "947--959",

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TY - JOUR

T1 - A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale

AU - Mucci, Armida

AU - Vignapiano, Annarita

AU - Bitter, István

AU - Austin, Stephen F.

AU - Delouche, Camille

AU - Dollfus, Sonia

AU - Erfurth, Andreas

AU - Fleischhacker, W. Wolfgang

AU - Giordano, Giulia M.

AU - Gladyshev, Igor

AU - Glenthøj, Birte

AU - Gütter, Karoline

AU - Hofer, Alex

AU - Hubeňák, Jan

AU - Kaiser, Stefan

AU - Libiger, Jan

AU - Melle, Ingrid

AU - Nielsen, Mette Ø.

AU - Papsuev, Oleg

AU - Rybakowski, Janusz K.

AU - Sachs, Gabriele

AU - Üçok, Alp

AU - Wojciak, Pawel

AU - Galderisi, Silvana

PY - 2019

Y1 - 2019

N2 - Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the consensus are available, studies still rely upon old assessment instruments, that do not reflect recent conceptualizations and might limit progress in the search for effective treatments. This is often the case in the European context, where one of the challenges encountered in designing large studies is the availability of validated instruments in the many languages of the continent. To address this challenge and promote sound research on negative symptoms in Europe, the ECNP Schizophrenia Network coordinated a large multicenter, multinational validation study of the Brief Negative Symptom Scale (BNSS). Clinically-stable subjects with schizophrenia (SCZ, N = 249) were recruited from 10 European Countries. Apart from BNSS, subjects were administered the Positive and Negative Syndrome Scale (PANSS) and standardized instruments for depression, extrapyramidal symptoms and psychosocial functioning. Results showed an excellent internal consistency, convergent and discriminant validity of BNSS and replicated a 5 factor-model. A larger number of subjects with predominant negative symptoms, i.e. the target population for clinical trials, was identified by using the BNSS compared to the PANSS. Regression analysis showed that BNSS-avolition, a key negative symptom poorly assessed by PANSS, explained 23.9% of psychosocial functioning, while no combination of the PANSS core negative symptoms showed the same impact on functioning. The study demonstrated that BNSS has substantial advantages with respect to PANSS for the identification of the avolition domain and subjects with predominant negative symptoms.

AB - Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the consensus are available, studies still rely upon old assessment instruments, that do not reflect recent conceptualizations and might limit progress in the search for effective treatments. This is often the case in the European context, where one of the challenges encountered in designing large studies is the availability of validated instruments in the many languages of the continent. To address this challenge and promote sound research on negative symptoms in Europe, the ECNP Schizophrenia Network coordinated a large multicenter, multinational validation study of the Brief Negative Symptom Scale (BNSS). Clinically-stable subjects with schizophrenia (SCZ, N = 249) were recruited from 10 European Countries. Apart from BNSS, subjects were administered the Positive and Negative Syndrome Scale (PANSS) and standardized instruments for depression, extrapyramidal symptoms and psychosocial functioning. Results showed an excellent internal consistency, convergent and discriminant validity of BNSS and replicated a 5 factor-model. A larger number of subjects with predominant negative symptoms, i.e. the target population for clinical trials, was identified by using the BNSS compared to the PANSS. Regression analysis showed that BNSS-avolition, a key negative symptom poorly assessed by PANSS, explained 23.9% of psychosocial functioning, while no combination of the PANSS core negative symptoms showed the same impact on functioning. The study demonstrated that BNSS has substantial advantages with respect to PANSS for the identification of the avolition domain and subjects with predominant negative symptoms.

KW - Avolition

KW - BNSS

KW - Functional outcome

KW - Negative symptoms

KW - PANSS-negative subscale

U2 - 10.1016/j.euroneuro.2019.05.006

DO - 10.1016/j.euroneuro.2019.05.006

M3 - Journal article

C2 - 31255394

AN - SCOPUS:85067890001

SN - 0924-977X

VL - 29

SP - 947

EP - 959

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 8

ER -

A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale

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