A heteromeric snake toxin and the molecular details of pain perception

TY - JOUR

T1 - A heteromeric snake toxin and the molecular details of pain perception

AU - Strømgaard, Kristian

AU - Kristensen, Anders Skov

N1 - Keywords: ion channels; pain; natural products; snake toxins

PY - 2012/4/23

Y1 - 2012/4/23

N2 - Gaining on pain: Two snake protein toxins combine to form a heteromeric complex, MitTx, which activates acid-sensing ion channels (ASICs) and elicits pain. MitTx is used to explore the roles of specific ASIC subtypes in pain pathways. These insights may provide new pharmacological tools ultimately leading to new treatments for pain.

AB - Gaining on pain: Two snake protein toxins combine to form a heteromeric complex, MitTx, which activates acid-sensing ion channels (ASICs) and elicits pain. MitTx is used to explore the roles of specific ASIC subtypes in pain pathways. These insights may provide new pharmacological tools ultimately leading to new treatments for pain.

U2 - 10.1002/anie.201200340

DO - 10.1002/anie.201200340

M3 - Journal article

C2 - 22422721

SN - 1433-7851

VL - 51

SP - 4009

EP - 4011

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 17

ER -