A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain

Teknik og materialevidenskab

• Assays 84%
• Fluorescence 82%
• Molecules 70%
• Screening 66%
• Proteins 65%
• Polarization 65%
• Forster resonance energy transfer 16%
• Dopamine 15%
• Peptides 13%
• Experiments 10%
• Fusion reactions 8%

Medicin og biovidenskab

• PDZ Domains 100%
• Fluorescence Polarization 97%
• Phosphotransferases 55%
• FSC 231 27%
• Proteins 26%
• AMPA 2 glutamate receptor ionotropic 19%
• Fluorescence Resonance Energy Transfer 16%
• Dopamine Plasma Membrane Transport Proteins 14%
• Cancer Pain 14%
• Glutamate Receptors 13%
• Neuralgia 12%
• Carrier Proteins 10%
• Stroke 8%
• Peptides 7%

Kemiske forbindelser

• Polarization 53%
• Fluorescence 41%
• Protein 29%
• Molecule 24%
• Fluorescence Resonance Energy Transfer 10%
• Dopamine 9%
• Green 7%
• Peptide 5%
• Application 3%