A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

TY - JOUR

T1 - A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

AU - Ribeiro Xavier, Anna L.

AU - Kress, Benjamin T.

AU - Goldman, Steven A.

AU - Lacerda de Menezes, João R.

AU - Nedergaard, Maiken

N1 - Copyright © 2015 the authors 0270-6474/15/3511848-14$15.00/0.

PY - 2015/8/26

Y1 - 2015/8/26

N2 - Microglia are involved in synaptic pruning both in development and in the mature CNS. In this study, we investigated whether microglia might further contribute to circuit plasticity by modulating neuronal recruitment from the neurogenic subventricular zone (SVZ) of the adult mouse striatum. We found that microglia residing in the SVZ and adjacent rostral migratory stream (RMS) comprise a morpho-logically and antigenically distinct phenotype of immune effectors. Whereas exhibiting characteristics of alternatively activated micro-glia, the SVZ/RMS microglia were clearly distinguished by their low expression of purinoceptors and lack of ATP-elicitable chemotaxis. Furthermore, the in vivo depletion of these microglia hampered the survival and migration of newly generated neuroblasts through the RMS to the olfactory bulb. SVZ and RMS microglia thus appear to comprise a functionally distinct class that is selectively adapted to the support and direction of neuronal integration into the olfactory circuitry. Therefore, this unique microglial subpopulation may serve as a novel target with which to modulate cellular addition from endogenous neural stem and progenitor cells of the adult brain.

AB - Microglia are involved in synaptic pruning both in development and in the mature CNS. In this study, we investigated whether microglia might further contribute to circuit plasticity by modulating neuronal recruitment from the neurogenic subventricular zone (SVZ) of the adult mouse striatum. We found that microglia residing in the SVZ and adjacent rostral migratory stream (RMS) comprise a morpho-logically and antigenically distinct phenotype of immune effectors. Whereas exhibiting characteristics of alternatively activated micro-glia, the SVZ/RMS microglia were clearly distinguished by their low expression of purinoceptors and lack of ATP-elicitable chemotaxis. Furthermore, the in vivo depletion of these microglia hampered the survival and migration of newly generated neuroblasts through the RMS to the olfactory bulb. SVZ and RMS microglia thus appear to comprise a functionally distinct class that is selectively adapted to the support and direction of neuronal integration into the olfactory circuitry. Therefore, this unique microglial subpopulation may serve as a novel target with which to modulate cellular addition from endogenous neural stem and progenitor cells of the adult brain.

KW - Animals

KW - Animals, Newborn

KW - Female

KW - Lateral Ventricles

KW - Male

KW - Mice

KW - Mice, 129 Strain

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Microglia

KW - Neural Stem Cells

KW - Neurogenesis

U2 - 10.1523/jneurosci.1217-15.2015

DO - 10.1523/jneurosci.1217-15.2015

M3 - Journal article

C2 - 26311768

SN - 0270-6474

VL - 35

SP - 11848

EP - 11861

JO - The Journal of neuroscience : the official journal of the Society for Neuroscience

JF - The Journal of neuroscience : the official journal of the Society for Neuroscience

IS - 34

ER -