A cortical source localization analysis of resting EEG data after remifentanil infusion

TY - JOUR

T1 - A cortical source localization analysis of resting EEG data after remifentanil infusion

AU - Khodayari-Rostamabad, Ahmad

AU - Graversen, Carina

AU - Malver, Lasse P

AU - Kurita, Geana P

AU - Christrup, Lona Louring

AU - Sjøgren, Per

AU - Drewes, Asbjørn M

N1 - Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - OBJECTIVE: To explore changes in current source density locations after remifentanil infusion in healthy volunteers using source localization of the electroencephalography (EEG).METHODS: EEG data was collected from 21 males using a 62-electrode system. Additionally, cognitive performance was evaluated by a continuous reaction time paradigm, and pain scores were obtained for experimental bone and heat stimuli. Data were recorded before and during treatment with remifentanil and placebo. Source localization was performed by sLORETA at delta (1-3.9Hz), theta (4-7.9Hz), alpha (8-12Hz), beta1 (12.1-18Hz), and beta2 (18.1-30Hz) frequency bands.RESULTS: Pre-treatment recordings demonstrated reproducible source characteristics. The alterations (i.e., pre- versus post-treatment) due to remifentanil were significantly and robustly different from placebo infusions. The results indicated that neurons in several brain areas including inferior frontal gyrus and insula at frontal lobe oscillated more strongly after remifentanil infusion compared to placebo. Furthermore, the source activity at delta band was correlated with continuous reaction time index.CONCLUSIONS: These results indicate that alterations in brain oscillations during remifentanil are mostly localized to frontal, fronto-temporal and fronto-central lobes and related to cognitive function.SIGNIFICANCE: The approach offers the potential to be used for understanding the underlying mechanism of action of remifentanil on brain activity.

AB - OBJECTIVE: To explore changes in current source density locations after remifentanil infusion in healthy volunteers using source localization of the electroencephalography (EEG).METHODS: EEG data was collected from 21 males using a 62-electrode system. Additionally, cognitive performance was evaluated by a continuous reaction time paradigm, and pain scores were obtained for experimental bone and heat stimuli. Data were recorded before and during treatment with remifentanil and placebo. Source localization was performed by sLORETA at delta (1-3.9Hz), theta (4-7.9Hz), alpha (8-12Hz), beta1 (12.1-18Hz), and beta2 (18.1-30Hz) frequency bands.RESULTS: Pre-treatment recordings demonstrated reproducible source characteristics. The alterations (i.e., pre- versus post-treatment) due to remifentanil were significantly and robustly different from placebo infusions. The results indicated that neurons in several brain areas including inferior frontal gyrus and insula at frontal lobe oscillated more strongly after remifentanil infusion compared to placebo. Furthermore, the source activity at delta band was correlated with continuous reaction time index.CONCLUSIONS: These results indicate that alterations in brain oscillations during remifentanil are mostly localized to frontal, fronto-temporal and fronto-central lobes and related to cognitive function.SIGNIFICANCE: The approach offers the potential to be used for understanding the underlying mechanism of action of remifentanil on brain activity.

U2 - 10.1016/j.clinph.2014.08.006

DO - 10.1016/j.clinph.2014.08.006

M3 - Journal article

C2 - 25227220

SN - 1567-424X

SN - 1872-8952

VL - 126

SP - 898

EP - 905

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 5

ER -