A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis

TY - JOUR

T1 - A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients

T2 - results from the IMMEnSE consortium and meta-analysis

AU - Ríos-Tamayo, Rafael

AU - Lupiañez, Carmen Belén

AU - Campa, Daniele

AU - Hielscher, Thomas

AU - Weinhold, Niels

AU - Martinez-Lopez, Joaquin

AU - Jerez, Andrés

AU - Landi, Stefano

AU - Jamroziak, Krzysztof

AU - Dumontet, Charles

AU - Wątek, Marzena

AU - Lesueur, Fabienne

AU - Reis, Rui Manuel

AU - Marques, Herlander

AU - Jurczyszyn, Artur

AU - Vogel, Ulla

AU - Buda, Gabriele

AU - García-Sanz, Ramón

AU - Orciuolo, Enrico

AU - Petrini, Mario

AU - Vangsted, Annette J

AU - Gemignani, Federica

AU - Försti, Asta

AU - Goldschmidt, Hartmut

AU - Hemminki, Kari

AU - Canzian, Federico

AU - Jurado, Manuel

AU - Sainz, Juan

PY - 2016

Y1 - 2016

N2 - Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8rs13266634 SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1Brs7501939 SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men.

AB - Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8rs13266634 SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1Brs7501939 SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men.

U2 - 10.18632/oncotarget.10665

DO - 10.18632/oncotarget.10665

M3 - Journal article

C2 - 27437873

SN - 1949-2553

VL - 7

SP - 59029

EP - 59048

JO - OncoTarget

JF - OncoTarget

IS - 37

ER -