@article{71fac5a0a0f311dd86a6000ea68e967b,
title = "A cell shrinkage-induced non-selective cation conductance with a novel pharmacology in Ehrlich-Lettre-ascites tumour cells.",
abstract = "In whole-cell recordings on Ehrlich-Lettre-ascites tumour (ELA) cells, the shrinkage-induced activation of a cation conductance with a selectivity ratio P(Na):P(Li):P(K):P(choline):P(NMDG) of 1.00:0.97:0.88:0.03:0.01 was observed. In order of potency, this conductance was blocked by Gd(3+)=benzamil>amiloride>ethyl-isopropyl-amiloride (EIPA). In patch-clamp studies using the cell-attached configuration, a 14 pS channel became detectable that was reversibly activated upon hypertonic cell shrinkage. It is concluded that ELA cells express a shrinkage-induced cation channel that may reflect a molecular link between amiloride-sensitive and -insensitive channels. In addition, because of its pharmacological profile, it may possibly be related to epithelial Na+ channels (ENaCs).",
author = "Peter Lawonn and Hoffmann, {Else K} and Charlotte Hougaard and Frank Wehner",
note = "Keywords: Animals; Carcinoma, Ehrlich Tumor; Cations; Cell Size; Electric Conductivity; Ion Channels; Patch-Clamp Techniques; Tumor Cells, Cultured",
year = "2003",
doi = "10.1016/S0014-5793(03)00210-2",
language = "English",
volume = "539",
pages = "115--9",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "1-3",
}