A 7-d exercise program increases high-molecular weight adiponectin in obese adults

TY - JOUR

T1 - A 7-d exercise program increases high-molecular weight adiponectin in obese adults

AU - Kelly, Karen R

AU - Blaszczak, Alecia

AU - Haus, Jacob M

AU - Patrick-Melin, Aimee

AU - Fealy, Ciaran E

AU - Solomon, Thomas

AU - Kalinski, Michael I

AU - Kirwan, John P

PY - 2012/1

Y1 - 2012/1

N2 - PURPOSE: High-molecular weight (HMW) adiponectin is the biologically active form of adiponectin and is related to enhanced insulin sensitivity and metabolic function. Previously, we found that 7 d of exercise improves insulin sensitivity in obese subjects; however, whether short-term exercise training affects HMW adiponectin in obese persons is unknown. METHODS: We examined the effect of seven consecutive days of supervised vigorous exercise (60 min•d -1, 85% HR max) on HMW adiponectin and leptin secretion in 17 obese individuals (age = 55 ± 3 yr; body mass index = 33.7 ± 0.9 kg•m -2). Insulin sensitivity was calculated from an oral glucose tolerance test (ISIOGTT) using the Matsuda Index. Fasting plasma HMW adiponectin and leptin were quantified from blood samples obtained before the ISIOGTT. Glucose and insulin measures were obtained before and every 30 min during the test. Dual-energy X-ray absorptiometry was used to determine body composition, and indirect calorimetry was used to assess fat oxidation. RESULTS: After the intervention, there was a significant increase in HMW adiponectin (3202 ± 543 vs 3878 ± 682 ng•mL -1, P = 0.02) and a decrease in leptin (36.8 ± 5.1 vs 31.1 ± 4.2 μg•mL -1, P = 0.03). Further, we observed an increase in ISIOGTT (1.7 ± 0.3 vs 2.1 ± 0.3, P = 0.04) and a decrease in glucose area under the curve (30,871 ± 2105 vs 28,469 ± 1657 mg•dL -1 for 3 h, P = 0.01). The increase in HMW adiponectin was positively associated with the increase in basal fat oxidation (r = 0.57, P = 0.03), consistent with an improvement in adipose tissue metabolic function. CONCLUSIONS: The data suggest that 7 d of exercise is sufficient not only to improve insulin sensitivity and fat oxidation but also to favorably alter adipokine secretion, independent of changes in body weight or composition.

AB - PURPOSE: High-molecular weight (HMW) adiponectin is the biologically active form of adiponectin and is related to enhanced insulin sensitivity and metabolic function. Previously, we found that 7 d of exercise improves insulin sensitivity in obese subjects; however, whether short-term exercise training affects HMW adiponectin in obese persons is unknown. METHODS: We examined the effect of seven consecutive days of supervised vigorous exercise (60 min•d -1, 85% HR max) on HMW adiponectin and leptin secretion in 17 obese individuals (age = 55 ± 3 yr; body mass index = 33.7 ± 0.9 kg•m -2). Insulin sensitivity was calculated from an oral glucose tolerance test (ISIOGTT) using the Matsuda Index. Fasting plasma HMW adiponectin and leptin were quantified from blood samples obtained before the ISIOGTT. Glucose and insulin measures were obtained before and every 30 min during the test. Dual-energy X-ray absorptiometry was used to determine body composition, and indirect calorimetry was used to assess fat oxidation. RESULTS: After the intervention, there was a significant increase in HMW adiponectin (3202 ± 543 vs 3878 ± 682 ng•mL -1, P = 0.02) and a decrease in leptin (36.8 ± 5.1 vs 31.1 ± 4.2 μg•mL -1, P = 0.03). Further, we observed an increase in ISIOGTT (1.7 ± 0.3 vs 2.1 ± 0.3, P = 0.04) and a decrease in glucose area under the curve (30,871 ± 2105 vs 28,469 ± 1657 mg•dL -1 for 3 h, P = 0.01). The increase in HMW adiponectin was positively associated with the increase in basal fat oxidation (r = 0.57, P = 0.03), consistent with an improvement in adipose tissue metabolic function. CONCLUSIONS: The data suggest that 7 d of exercise is sufficient not only to improve insulin sensitivity and fat oxidation but also to favorably alter adipokine secretion, independent of changes in body weight or composition.

KW - Adiponectin

KW - Adipose Tissue

KW - Blood Glucose

KW - Body Composition

KW - Exercise

KW - Fats

KW - Female

KW - Glucose Tolerance Test

KW - Heart Rate

KW - Humans

KW - Insulin

KW - Insulin Resistance

KW - Leptin

KW - Male

KW - Middle Aged

KW - Obesity

U2 - 10.1249/mss.0b013e318228bf85

DO - 10.1249/mss.0b013e318228bf85

M3 - Journal article

C2 - 21685815

SN - 0195-9131

VL - 44

SP - 69

EP - 74

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

IS - 1

ER -