2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes

Thomas Morville; Mads Rosenkilde; Nick Mattsson; Flemming Dela; Jørn W. Helge; Hanne K. Rasmusen

doi:10.1080/00913847.2018.1477403

2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes

Thomas Morville, Mads Rosenkilde, Nick Mattsson, Flemming Dela^*, Jørn W. Helge, Hanne K. Rasmusen

^*Corresponding author af dette arbejde

Abstract

OBJECTIVES: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion.

METHODS: We studied 6 elderly male athletes (61 ± 8 years (mean ± SD); baseline [Formula: see text]O 2max 48 ± 5 ml·kg -1·min -1) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km.

RESULTS: Data collected after the cessation of exercise on the 14th day revealed significant increases in average size of the left atrium (3.5 ± 0.4 to 4.0 ± 0.3 cm; p = 0.02) and left ventricular end systolic volume (47 ± 2 to 52 ± 5 ml; p = 0.004), with no other significant changes in cardiac size or function. Small, transient increases in cardiac biomarkers (troponin T, creatine kinase myocardial band, and N-terminal pro-brain natriuretic peptide) (p < 0.01) were observed 2 h after completion of cycling but no changes in systolic (including strain-analyses) or diastolic cardiac function were observed at rest. [Formula: see text]O 2max was significantly lower at the 28 h time point than at baseline (p < 0.02). Plasma concentrations of total- (p < 0.01) and low-density lipoprotein-cholesterol (p < 0.01) were markedly lower after exercise. Systolic blood pressure was unchanged, but diastolic pressure was significantly lower after exercise than at baseline.

CONCLUSIONS: The results suggest that repeated moderate intensity exercise in elderly men was associated with a transient increase in cardiac biomarkers while cardiac function remained unaltered. A favorable reduction in blood lipids and diastolic blood pressure were seen for >28 h after the end of activity. An unexplained symptomless severe plasma hyponatremia developed in 3 of 6 subjects 28 h after the end of activity.

Originalsprog	Engelsk
Tidsskrift	Physician and Sportsmedicine
Vol/bind	46
Udgave nummer	3
Sider (fra-til)	263-268
Antal sider	6
ISSN	0091-3847
DOI	https://doi.org/10.1080/00913847.2018.1477403
Status	Udgivet - 2018

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10.1080/00913847.2018.1477403

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title = "2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes",

abstract = "OBJECTIVES: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion.METHODS: We studied 6 elderly male athletes (61 ± 8 years (mean ± SD); baseline [Formula: see text]O 2max 48 ± 5 ml·kg -1·min -1) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km. RESULTS: Data collected after the cessation of exercise on the 14th day revealed significant increases in average size of the left atrium (3.5 ± 0.4 to 4.0 ± 0.3 cm; p = 0.02) and left ventricular end systolic volume (47 ± 2 to 52 ± 5 ml; p = 0.004), with no other significant changes in cardiac size or function. Small, transient increases in cardiac biomarkers (troponin T, creatine kinase myocardial band, and N-terminal pro-brain natriuretic peptide) (p < 0.01) were observed 2 h after completion of cycling but no changes in systolic (including strain-analyses) or diastolic cardiac function were observed at rest. [Formula: see text]O 2max was significantly lower at the 28 h time point than at baseline (p < 0.02). Plasma concentrations of total- (p < 0.01) and low-density lipoprotein-cholesterol (p < 0.01) were markedly lower after exercise. Systolic blood pressure was unchanged, but diastolic pressure was significantly lower after exercise than at baseline. CONCLUSIONS: The results suggest that repeated moderate intensity exercise in elderly men was associated with a transient increase in cardiac biomarkers while cardiac function remained unaltered. A favorable reduction in blood lipids and diastolic blood pressure were seen for >28 h after the end of activity. An unexplained symptomless severe plasma hyponatremia developed in 3 of 6 subjects 28 h after the end of activity.",

keywords = "blood lipids, blood pressure, echocardiography, long-distance cycling, Master athletes",

author = "Thomas Morville and Mads Rosenkilde and Nick Mattsson and Flemming Dela and Helge, {J{\o}rn W.} and Rasmusen, {Hanne K.}",

year = "2018",

doi = "10.1080/00913847.2018.1477403",

language = "English",

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T1 - 2706 km cycling in 2 weeks

T2 - effects on cardiac function in 6 elderly male athletes

AU - Morville, Thomas

AU - Rosenkilde, Mads

AU - Mattsson, Nick

AU - Dela, Flemming

AU - Helge, Jørn W.

AU - Rasmusen, Hanne K.

PY - 2018

Y1 - 2018

N2 - OBJECTIVES: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion.METHODS: We studied 6 elderly male athletes (61 ± 8 years (mean ± SD); baseline [Formula: see text]O 2max 48 ± 5 ml·kg -1·min -1) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km. RESULTS: Data collected after the cessation of exercise on the 14th day revealed significant increases in average size of the left atrium (3.5 ± 0.4 to 4.0 ± 0.3 cm; p = 0.02) and left ventricular end systolic volume (47 ± 2 to 52 ± 5 ml; p = 0.004), with no other significant changes in cardiac size or function. Small, transient increases in cardiac biomarkers (troponin T, creatine kinase myocardial band, and N-terminal pro-brain natriuretic peptide) (p < 0.01) were observed 2 h after completion of cycling but no changes in systolic (including strain-analyses) or diastolic cardiac function were observed at rest. [Formula: see text]O 2max was significantly lower at the 28 h time point than at baseline (p < 0.02). Plasma concentrations of total- (p < 0.01) and low-density lipoprotein-cholesterol (p < 0.01) were markedly lower after exercise. Systolic blood pressure was unchanged, but diastolic pressure was significantly lower after exercise than at baseline. CONCLUSIONS: The results suggest that repeated moderate intensity exercise in elderly men was associated with a transient increase in cardiac biomarkers while cardiac function remained unaltered. A favorable reduction in blood lipids and diastolic blood pressure were seen for >28 h after the end of activity. An unexplained symptomless severe plasma hyponatremia developed in 3 of 6 subjects 28 h after the end of activity.

AB - OBJECTIVES: Physiological effects of exercise on trained and untrained individuals have been studied extensively. Typically, young or middle-aged individuals are examined before and after short periods of vigorous exertion.METHODS: We studied 6 elderly male athletes (61 ± 8 years (mean ± SD); baseline [Formula: see text]O 2max 48 ± 5 ml·kg -1·min -1) with focus on cardiac function and biomarkers following 14 consecutive days of moderate intensity exercise. Cardiac dimensions, function, biomarkers, and other measures of cardiovascular health were examined at baseline and 2 and 28 h after the last day of cycling a total of 2706 km. RESULTS: Data collected after the cessation of exercise on the 14th day revealed significant increases in average size of the left atrium (3.5 ± 0.4 to 4.0 ± 0.3 cm; p = 0.02) and left ventricular end systolic volume (47 ± 2 to 52 ± 5 ml; p = 0.004), with no other significant changes in cardiac size or function. Small, transient increases in cardiac biomarkers (troponin T, creatine kinase myocardial band, and N-terminal pro-brain natriuretic peptide) (p < 0.01) were observed 2 h after completion of cycling but no changes in systolic (including strain-analyses) or diastolic cardiac function were observed at rest. [Formula: see text]O 2max was significantly lower at the 28 h time point than at baseline (p < 0.02). Plasma concentrations of total- (p < 0.01) and low-density lipoprotein-cholesterol (p < 0.01) were markedly lower after exercise. Systolic blood pressure was unchanged, but diastolic pressure was significantly lower after exercise than at baseline. CONCLUSIONS: The results suggest that repeated moderate intensity exercise in elderly men was associated with a transient increase in cardiac biomarkers while cardiac function remained unaltered. A favorable reduction in blood lipids and diastolic blood pressure were seen for >28 h after the end of activity. An unexplained symptomless severe plasma hyponatremia developed in 3 of 6 subjects 28 h after the end of activity.

KW - blood lipids

KW - blood pressure

KW - echocardiography

KW - long-distance cycling

KW - Master athletes

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DO - 10.1080/00913847.2018.1477403

M3 - Journal article

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SN - 0091-3847

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JO - Physician and Sportsmedicine

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ER -

2706 km cycling in 2 weeks: effects on cardiac function in 6 elderly male athletes

Abstract

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