TY - JOUR
T1 - 10 year course of IQ in first-episode psychosis
T2 - Relationship between duration of psychosis and long-term intellectual trajectories
AU - Barder, Helene Eidsmo
AU - Sundet, Kjetil
AU - Rund, Bjørn Rishovd
AU - Evensen, Julie
AU - Haahr, Ulrik
AU - ten Velden Hegelstad, Wenche
AU - Joa, Inge
AU - Johannessen, Jan Olav
AU - Langeveld, Johannes
AU - Larsen, Tor Ketil
AU - Melle, Ingrid
AU - Opjordsmoen, Stein
AU - Røssberg, Jan Ivar
AU - Simonsen, Erik
AU - Vaglum, Per
AU - McGlashan, Thomas
AU - Friis, Svein P I
N1 - Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/2/28
Y1 - 2015/2/28
N2 - A substantial proportion of patients suffering from schizophrenia-spectrum disorders (SSDs) exhibit a general intellectual impairment at illness onset, but the subsequent intellectual course remains unclear. Relationships between accumulated time in psychosis and long-term intellectual functioning are largely uninvestigated, but may identify subgroups with different intellectual trajectories. Eighty-nine first-episode psychosis patients were investigated on IQ at baseline and at 10-years follow-up. Total time in psychosis was defined as two separate variables; Duration of psychosis before start of treatment (i.e. duration of untreated psychosis: DUP), and duration of psychosis after start of treatment (DAT). The sample was divided in three equal groups based on DUP and DAT, respectively. To investigate if diagnosis could separate IQ-trajectories beyond that of psychotic duration, two diagnostic categories were defined: core versus non-core SSDs. No significant change in IQ was found for the total sample. Intellectual course was not related to DUP or stringency of diagnostic category. However, a subgroup with long DAT demonstrated a significant intellectual decline, mainly associated with a weaker performance on test of immediate verbal recall/working memory (WAIS-R Digit Span). This indicates a relationship between accumulated duration of psychosis and long-term intellectual course, irrespective of diagnostic category, in a significant subgroup of patients.
AB - A substantial proportion of patients suffering from schizophrenia-spectrum disorders (SSDs) exhibit a general intellectual impairment at illness onset, but the subsequent intellectual course remains unclear. Relationships between accumulated time in psychosis and long-term intellectual functioning are largely uninvestigated, but may identify subgroups with different intellectual trajectories. Eighty-nine first-episode psychosis patients were investigated on IQ at baseline and at 10-years follow-up. Total time in psychosis was defined as two separate variables; Duration of psychosis before start of treatment (i.e. duration of untreated psychosis: DUP), and duration of psychosis after start of treatment (DAT). The sample was divided in three equal groups based on DUP and DAT, respectively. To investigate if diagnosis could separate IQ-trajectories beyond that of psychotic duration, two diagnostic categories were defined: core versus non-core SSDs. No significant change in IQ was found for the total sample. Intellectual course was not related to DUP or stringency of diagnostic category. However, a subgroup with long DAT demonstrated a significant intellectual decline, mainly associated with a weaker performance on test of immediate verbal recall/working memory (WAIS-R Digit Span). This indicates a relationship between accumulated duration of psychosis and long-term intellectual course, irrespective of diagnostic category, in a significant subgroup of patients.
U2 - 10.1016/j.psychres.2014.11.054
DO - 10.1016/j.psychres.2014.11.054
M3 - Journal article
C2 - 25535007
SN - 0165-1781
VL - 225
SP - 515
EP - 521
JO - Psychiatry Research
JF - Psychiatry Research
IS - 3
ER -