β Cell Dysfunction in Type 2 Diabetes: Drained of Energy?

TY - JOUR

T1 - β Cell Dysfunction in Type 2 Diabetes

T2 - Drained of Energy?

AU - Knudsen, Jakob G.

AU - Rorsman, Patrik

N1 - Copyright © 2018 Elsevier Inc. All rights reserved.

PY - 2019/1/8

Y1 - 2019/1/8

N2 - Type 2 diabetes is a progressive disorder, but exactly how the progression occurs remains unknown. In this issue of Cell Metabolism, Zhang et al. (2019) present evidence that diabetes, via hyperglycemia, leads to aberrant insertion of a mitochondrial ion channel in the plasma membrane, rendering it leaky to key intracellular signaling molecules with resultant suppression of insulin secretion.

AB - Type 2 diabetes is a progressive disorder, but exactly how the progression occurs remains unknown. In this issue of Cell Metabolism, Zhang et al. (2019) present evidence that diabetes, via hyperglycemia, leads to aberrant insertion of a mitochondrial ion channel in the plasma membrane, rendering it leaky to key intracellular signaling molecules with resultant suppression of insulin secretion.

U2 - 10.1016/j.cmet.2018.12.015

DO - 10.1016/j.cmet.2018.12.015

M3 - Editorial

C2 - 30625305

SN - 1550-4131

VL - 29

SP - 1

EP - 2

JO - Cell Metabolism

JF - Cell Metabolism

IS - 1

ER -