Signe Ziir Ingvarsen

Publikation

Publikationer pr. år 2007 2008 2009 2011 2012 2013 2017

• 16 Tidsskriftartikel
• 1 Ph.d.-afhandling
• 1 Review

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2017

  The collagen receptor uPARAP/Endo180 as a novel target for antibody-drug conjugate mediated treatment of mesenchymal and leukemic cancers

  Nielsen, C. F., van Putten, S. M., Lund, I. K., Melander, M. C., Nørregaard, K. S., Jürgensen, H. J., Reckzeh, K., Christensen, K. R., Ingvarsen, S. Z., Gårdsvoll, H., Jensen, K. E., Hamerlik, P., Engelholm, L. H. & Behrendt, N., 2017, I: OncoTarget. 8, 27, s. 44605-44624 20 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Endo180 100%
  • Collagen Receptors 76%
  • Immunoconjugates 68%
  • Neoplasms 16%
  • Glioblastoma 12%
  13 Citationer (Scopus)

  355 Downloads (Pure)
• 2016

  Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180

  Engelholm, L. H., Carlsen Melander, E. M., Hald, A., Persson, M., Madsen, D. H., Jürgensen, H. J., Johansson, K., Nielsen, C., Nørregaard, K. S., Ingvarsen, S. Z., Kjaer, A., Trovik, C. S., Lærum, O. D., Bugge, T. H., Eide, J. & Behrendt, N., 1 jan. 2016, I: Journal of Pathology. 238, 1, s. 120-33 14 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Endo180 100%
  • Collagen Receptors 76%
  • Bone Neoplasms 63%
  • Bone and Bones 30%
  • Sarcoma 26%
  11 Citationer (Scopus)
• 2014

  Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells

  Gaublomme, D., Buyens, T., De Groef, L., Stakenborg, M., Janssens, E., Ingvarsen, S., Porse, A., Behrendt, N. & Moons, L., jun. 2014, I: Journal of Neurochemistry. 129, 6, s. 966-979 14 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Matrix Metalloproteinase 14 100%
  • Neuronal Outgrowth 83%
  • Retinal 83%
  • Retinal Ganglion Cells 82%
  • Matrix Metalloproteinase 2 79%
  19 Citationer (Scopus)
• 2013

  A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP

  Shiryaev, S. A., Remacle, A. G., Golubkov, V. S., Ingvarsen, S., Porse, A., Behrendt, N., Cieplak, P. & Strongin, A. Y., 2 dec. 2013, I: Oncogenesis. 2, s. e80

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Matrix Metalloproteinase 14 100%
  • Tissue Inhibitor of Metalloproteinase-2 93%
  • Matrix Metalloproteinase 2 79%
  • Monoclonal Antibodies 53%
  • Membrane-Associated Matrix Metalloproteinases 30%
  28 Citationer (Scopus)

• Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis

  Madsen, D. H., Jürgensen, H. J., Ingvarsen, S., Melander, M. C., Albrechtsen, R., Hald, A., Holmbeck, K., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 5 aug. 2013, I: PloS one. 8, 8, s. e71261

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Endo180 100%
  • Collagen 80%
  • Homeostasis 77%
  • Collagen Receptors 76%
  • gelatinase A 73%
  21 Citationer (Scopus)

• Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis

  Ingvarsen, S., Porse, A., Erpicum, C., Maertens, L., Jürgensen, H. J., Madsen, D. H., Melander, M. C., Gårdsvoll, H., Høyer-Hansen, G., Noel, A., Holmbeck, K., Engelholm, L. H. & Behrendt, N., 12 apr. 2013, I: Journal of Biological Chemistry. 288, 15, s. 10195-204 10 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Lymphangiogenesis 100%
  • Metalloproteases 78%
  • Collagen 69%
  • Block Like Crystal 49%
  • progelatinase 23%
  41 Citationer (Scopus)
• 2012

  Endocytic collagen degradation: a novel mechanism involved in protection against liver fibrosis

  Madsen, D. H., Jürgensen, H. J., Ingvarsen, S. Z., Melander, M. C., Vainer, B., Egerod, K. L., Hald, A., Rønø, B., Madsen, C. A., Bugge, T. H., Engelholm, L. H. & Behrendt, N., maj 2012, I: Journal of Pathology. 227, 1, s. 94-105 12 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Endo180 100%
  • Liver Cirrhosis 63%
  • Collagen 52%
  • Collagen Receptors 38%
  • Hepatic Stellate Cells 31%
  32 Citationer (Scopus)

• Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo

  Lund, I. K., Rasch, M. G., Ingvarsen, S., Pass, J., Madsen, D. H., Engelholm, L. H., Behrendt, N. & Høyer-Hansen, G., 2012, I: Frontiers in Pharmacology. 3, s. 122

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Peptide Hydrolases 100%
  • Monoclonal Antibodies 87%
  • Plasminogen Activators 70%
  • Urokinase Plasminogen Activator Receptors 55%
  • Genes 48%
  9 Citationer (Scopus)

• Interfering with membrane type matrix metalloproteases in processes of extracellular matrix turnover

  Ingvarsen, S., 2012, Faculty of Science, University of Copenhagen.

  Publikation: Bog/antologi/afhandling/rapport › Ph.d.-afhandling
• 2011

  A novel functional role of collagen glycosylation: interaction with the endocytic collagen receptor uPARAP/ENDO 180

  Jürgensen, H. J., Madsen, D. H., Ingvarsen, S., Melander, M. C., Gårdsvoll, H., Patthy, L., Engelholm, L. H. & Behrendt, N., 16 sep. 2011, I: Journal of Biological Chemistry. 286, 37, s. 32736-48 13 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Collagen Receptors 100%
  • Urokinase Plasminogen Activator Receptors 94%
  • Endo180 73%
  • Glycosylation 69%
  • Collagen 64%
  55 Citationer (Scopus)

• The non-phagocytic route of collagen uptake: a distinct degradation pathway

  Madsen, D. H., Ingvarsen, S., Jürgensen, H. J., Melander, M. C., Kjøller, L., Moyer, A., Honoré, C., Madsen, M. C., Garred, P., Burgdorf, S., Bugge, T. H., Behrendt, N. & Engelholm, L. H., 29 jul. 2011, I: The Journal of Biological Chemistry. 286, 30, s. 26996-7010 15 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Endo180 100%
  • Collagen 97%
  • Urokinase Plasminogen Activator Receptors 71%
  • mannose receptor 36%
  • Protein 35%
  77 Citationer (Scopus)
• 2009

  Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

  Rowe, R. G., Li, X. Y., Hu, Y., Saunders, T. L., Virtanen, I., A., G. D. H., Becker, K. F., Ingvarsen, S., Engelholm, L. H., Bommer, G. T., Fearon, E. R. & Weiss, S. J., 2009, I: Journal of Cell Biology. 184, 3, s. 399-408 9 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  118 Citationer (Scopus)

• MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny

  Szabova, L., Yamada, S. S., Wimer, H. F., Chrysovergis, K., Ingvarsen, S., Behrendt, N., Engelholm, L. H. & Holmbeck, K., nov. 2009, I: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 24, 11, s. 1905-16 12 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Matrix Metalloproteinase 14 100%
  • Collagen Type II 84%
  • Cartilage 63%
  • Stem Cells 53%
  • Bone and Bones 43%

• MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny

  Szabova, L., Yamada, S. S., Wimer, H., Chrysovergis, K., Ingvarsen, S., Behrendt, N., Engelholm, L. H. & Holmbeck, K., 2009, I: Journal of Bone and Mineral Research. 24, 11, s. 1905-1916 11 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  22 Citationer (Scopus)

• The collagen receptor uPARAP/Endo180

  Engelholm, L. H., Ingvarsen, S., Jürgensen, H. J., Hillig, T., Madsen, D. H., Nielsen, B. S. & Behrendt, N., 1 jan. 2009, I: Frontiers in Bioscience. 14, s. 2103-14 12 s.

  Publikation: Bidrag til tidsskrift › Review › peer review

  • Endo180 100%
  • Collagen Receptors 76%
  • Collagen 48%
  • Urokinase Plasminogen Activator Receptors 28%
  • Protein 15%
• 2008

  A composite role of vitronectin and urokinase in the modulation of cell morphology upon expression of the urokinase receptor

  Hillig, T., Engelholm, L. H., Ingvarsen, S., Madsen, D. H., Gårdsvoll, H., Larsen, J. K., Ploug, M., Danø, K., Kjøller, L. & Behrendt, N., 30 maj 2008, I: Journal of Biological Chemistry. 283, 22, s. 15217-15223 7 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Vitronectin 100%
  • Urokinase-Type Plasminogen Activator 84%
  • Peptide 42%
  • Protein Hydrolysis 39%
  • Composite Material 36%
  26 Citationer (Scopus)

• Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells

  Ingvarsen, S., Madsen, D. H., Hillig, T., Lund, L. R., Holmbeck, K., Behrendt, N. & Engelholm, L. H., jul. 2008, I: Biological Chemistry. 389, 7, s. 943-953

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
• 2007

  Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation

  Madsen, D. H., Engelholm, L. H., Ingvarsen, S., Hillig, T., Wagenaar-Miller, R. A., Kjøller, L., Gårdsvoll, H., Høyer-Hansen, G., Holmbeck, K., Bugge, T. H. & Behrendt, N., 14 sep. 2007, I: The Journal of Biological Chemistry. 282, 37, s. 27037-45 9 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

  • Endo180 100%
  • Urokinase Plasminogen Activator Receptors 71%
  • Collagenases 56%
  • Collagen 48%
  • Fibroblasts 38%
  96 Citationer (Scopus)