Jonas Sigurd Mortensen

Publikation

Publikationer pr. år 2015 2016 2017 2018 2019 2019

• 25 Tidsskriftartikel

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2019

  Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability

  Bae, H. E., Du, Y., Hariharan, P., Mortensen, J. S., Kumar, K. K., Ha, B., Das, M., Lee, H. S., Loland, C. J., Guan, L., Kobilka, B. K. & Chae, P. S., 2019, I: Chemical Science. 10, 4, s. 1107-1116

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  • Maltose 100%
  • Amphophile 89%
  • Detergent 79%
  • Glycol 77%
  • Protein 34%
  11 Citationer (Scopus)

  26 Downloads (Pure)

• Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability

  Sadaf, A., Ramos, M., Mortensen, J. S., Du, Y., Bae, H. E., Munk, C. F., Hariharan, P., Byrne, B., Kobilka, B. K., Loland, C. J., Guan, L. & Chae, P. S., 16 aug. 2019, I: ACS chemical biology. 14, 8, s. 1717-1726 10 s.

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  • Monosaccharides 100%
  • Glycosides 93%
  • Protein Stability 91%
  • Amphophile 81%
  • Detergents 81%
  1 Citationer (Scopus)

• Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability

  Ehsan, M., Du, Y., Mortensen, J. S., Hariharan, P., Qu, Q., Ghani, L., Das, M., Grethen, A., Byrne, B., Skiniotis, G., Keller, S., Loland, C. J., Guan, L., Kobilka, B. K. & Chae, P. S., 2 sep. 2019, I: Chemistry: A European Journal. 25, 49, s. 11545-11554

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  • Detergents 100%
  • Self assembly 95%
  • Detergent 68%
  • Proteins 66%
  • Membranes 61%
  2 Citationer (Scopus)

• Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study

  Ehsan, M., Kumar, A., Mortensen, J. S., Du, Y., Hariharan, P., Kumar, K. K., Ha, B., Byrne, B., Guan, L., Kobilka, B. K., Loland, C. J. & Chae, P. S., 3 jun. 2019, I: Chemistry - An Asian Journal. 14, 11, s. 1926-1931 6 s.

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  • Rubiaceae 100%
  • Membrane Proteins 59%
  • Fluorescence Spectrometry 46%
  • Micelles 43%
  • Proton Magnetic Resonance Spectroscopy 41%
  4 Citationer (Scopus)

• Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability

  Das, M., Du, Y., Mortensen, J. S., Ramos, M., Ghani, L., Lee, H. J., Bae, H. E., Byrne, B., Guan, L., Loland, C. J., Kobilka, B. K. & Chae, P. S., 2019, I: Organic & Biomolecular Chemistry. 17, 12, s. 3249-3257 9 s.

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  • Amphophile 100%
  • Detergent 88%
  • Micelle 73%
  • Protein 39%
  • Adrenergic 15%
  6 Citationer (Scopus)
• 2018

  A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability

  Hussain, H., Helton, T., Du, Y., Mortensen, J. S., Hariharan, P., Ehsan, M., Byrne, B., Loland, C. J., Kobilka, B. K., Guan, L. & Chae, P. S., 2018, I: Analyst. 143, 23, s. 5702-5710 9 s.

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  • Amphiphiles 100%
  • Protein Stability 62%
  • Mannitol 60%
  • Amphophile 55%
  • Proteins 48%

• An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability

  Das, M., Du, Y., Mortensen, J. S., Bae, H. E., Byrne, B., Loland, C. J., Kobilka, B. K. & Chae, P. S., 11 jul. 2018, I: Chemistry - A European Journal. 24, 39, s. 9860-9868 9 s.

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  • Amphiphiles 100%
  • Detergents 72%
  • Amphophile 55%
  • Detergent 49%
  • Proteins 48%
  8 Citationer (Scopus)

• Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy

  Das, M., Du, Y., Mortensen, J. S., Hariharan, P., Lee, H. S., Byrne, B., Loland, C. J., Guan, L., Kobilka, B. K. & Chae, P. S., 2018, I: ChemBioChem. 19, 20, s. 2225-2232 8 s.

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  • Amphophile 100%
  • Membrane Proteins 78%
  • Detergents 49%
  • Protein 39%
  • Ranidae 37%
  2 Citationer (Scopus)

• Steroid-based amphiphiles for membrane protein study: The importance of alkyl spacers for protein stability

  Ehsan, M., Das, M., Stern, V., Du, Y., Mortensen, J. S., Hariharan, P., Byrne, B., Loland, C. J., Kobilka, B. K., Guan, L. & Chae, P. S., 4 jul. 2018, I: ChemBioChem. 19, 13, s. 1433-1443 11 s.

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  • Protein Stability 100%
  • Amphophile 89%
  • Membrane Proteins 70%
  • Steroids 63%
  • Detergents 49%
  1 Citationer (Scopus)

• Vitamin E-based glycoside amphiphiles for membrane protein structural studies

  Ehsan, M., Du, Y., Molist, I., Seven, A. B., Hariharan, P., Mortensen, J. S., Ghani, L., Loland, C. J., Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 2018, I: Organic and Biomolecular Chemistry. 16, 14, s. 2489-2498 10 s.

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  • Amphophile 100%
  • Vitamin 96%
  • Glycoside 90%
  • Detergent 75%
  • Protein 39%
  2 Citationer (Scopus)
• 2017

  Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region

  Das, M., Du, Y., Mortensen, J. S., Ribeiro, O., Hariharan, P., Guan, L., Loland, C. J., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, I: Chemical Science. 2, s. 1169-1177 9 s.

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  • Stereoisomer 100%
  • Chirality 91%
  • Detergent 91%
  • Amphophile 82%
  • Protein 40%
  8 Citationer (Scopus)

  67 Downloads (Pure)

• Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties

  Das, M., Du, Y., Ribeiro, O., Hariharan, P., Mortensen, J. S., Patra, D., Skiniotis, G., Loland, C. J., Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 1 mar. 2017, I: Journal of the American Chemical Society. 139, 8, s. 3072-3081

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  • Norbornanes 100%
  • Detergents 68%
  • Detergent 46%
  • Diastereomer 45%
  • Proteins 45%
  27 Citationer (Scopus)

• Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study

  Sadaf, A., Du, Y., Santillan, C., Mortensen, J. S., Molist, I., Seven, A. B., Hariharan, P., Skiniotis, G., Loland, C. J., Kobilka, B. K., Guan, L., Byrne, B. & Chae, P. S., 2017, I: Chemical Science. 8, 12, s. 8315-8324 10 s.

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  • Amphophile 100%
  • Detergent 64%
  • Protein 39%
  • Adrenergic 22%
  • Solubilization 8%
  13 Citationer (Scopus)

  38 Downloads (Pure)

• Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR

  Erlendsson, S., Gotfryd, K., Larsen, F. H., Mortensen, J. S., Geiger, M-A., van Rossum, B-J., Oschkinat, H., Gether, U., Teilum, K. & Løland, C. J., 24 jan. 2017, I: eLife. 6, 9 s., e19314.

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  • Plasma Membrane Neurotransmitter Transport Proteins 100%
  • Neurotransmitter 58%
  • Solid-State NMR 53%
  • Binding Sites 40%
  • Binding Site 37%
  9 Citationer (Scopus)

  99 Downloads (Pure)

• New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies

  Ehsan, M., Ghani, L., Du, Y., Hariharan, P., Mortensen, J. S., Ribeiro, O., Hu, H., Skiniotis, G., Loland, C. J., Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., okt. 2017, I: Analyst. 142, 20, s. 3889-3898 10 s.

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  • Amphiphiles 100%
  • Rubiaceae 73%
  • Amphophile 55%
  • Protein Structure 51%
  • Proteins 48%
  5 Citationer (Scopus)

• Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability

  Hussain, H., Du, Y., Tikhonova, E., Mortensen, J. S., Ribeiro, O., Santillan, C., Das, M., Ehsan, M., Loland, C. J., Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, I: Chemistry - A European Journal. 23, 28, s. 6724-6729 6 s.

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  • Glycosides 100%
  • Detergents 74%
  • Glycoside 51%
  • Amphiphiles 51%
  • Detergent 50%
  14 Citationer (Scopus)

• Tandem malonate-based glucosides (TMGs) for membrane protein structural studies

  Hussain, H., Mortensen, J. S., Du, Y., Santillan, C., Ribeiro, O., Go, J., Hariharan, P., Loland, C. J., Guan, L., Kobilka, B. K., Byrne, B. & Chae, P. S., 2017, I: Scientific Reports. 7, 1, 11 s., 3963.

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  • malonic acid 100%
  • Glucosides 85%
  • Membrane Proteins 53%
  • Detergents 26%
  • Surface-Active Agents 13%
  8 Citationer (Scopus)

  69 Downloads (Pure)
• 2016

  Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation

  Hussain, H., Du, Y., Scull, N. J., Mortensen, J. S., Tarrasch, J., Bae, H. E., Loland, C. J., Byrne, B., Kobilka, B. K. & Chae, P. S., 17 maj 2016, I: Chemistry: A European Journal. 22, 21, s. 7068-7073 6 s.

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  • Amphiphiles 100%
  • Amphophile 55%
  • Solubilization 51%
  • Proteins 48%
  • Stabilization 44%
  23 Citationer (Scopus)

• A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study

  Sadaf, A., Mortensen, J. S., Capaldi, S., Tikhonova, E., Hariharan, P., de Castro Ribeiro, O., Loland, C. J., Guan, L., Byrne, B. & Chae, P. S., 1 mar. 2016, I: Chemical Science. 7, 3, s. 1933-1939 7 s.

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  • Glucoside 100%
  • Detergent 46%
  • Protein 35%
  • Biomacromolecule 15%
  • Hydrophobic Surface 13%
  23 Citationer (Scopus)

  86 Downloads (Pure)

• Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies

  Ehsan, M., Du, Y., Scull, N. J., Tikhonova, E., Tarrasch, J., Mortensen, J. S., Loland, C. J., Skiniotis, G., Guan, L., Byrne, B., Kobilka, B. K. & Chae, P. S., 23 mar. 2016, I: Journal of the American Chemical Society. 138, 11, s. 3789-3796 8 s.

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  • Amphiphiles 100%
  • Detergents 62%
  • Amphophile 55%
  • Proteins 48%
  • Membranes 44%
  40 Citationer (Scopus)

• Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length

  Cho, K. H., Hariharan, P., Mortensen, J. S., Du, Y., Nielsen, A. K., Byrne, B., Kobilka, B. K., Loland, C. J., Guan, L. & Chae, P. S., 14 dec. 2016, I: ChemBioChem. 17, 24, s. 2334–2339

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  • Protein Stability 100%
  • Detergents 88%
  • Detergent 78%
  • Membrane Proteins 70%
  • Length 50%
  10 Citationer (Scopus)

• Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy

  Cho, K. H., Ribeiro, O., Du, Y., Tikhonova, E., Mortensen, J., Markham, K., Hariharan, P., Løland, C., Guan, L., Kobilka, B., Byrne, B. & Chae, P. S., 23 dec. 2016, I: Chemistry: A European Journal. 22, 52, s. 18833–18839

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  • Amphiphiles 100%
  • Glucosides 98%
  • Detergents 72%
  • Glucoside 60%
  • Amphophile 55%
  10 Citationer (Scopus)

• Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

  Bae, H. E., Mortensen, J. S., Ribeiro, O., Du, Y., Ehsan, M., Kobilka, B. K., Loland, C. J., Byrne, B. & Chae, P. S., 4 okt. 2016, I: Chemical communications (Cambridge, England). 52, 81, s. 12104-12107 4 s.

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  • Glycols 100%
  • Glycol 72%
  • Detergents 72%
  • Proteins 72%
  • Stabilization 66%
  9 Citationer (Scopus)

• Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter

  Billesbølle, C. B., Mortensen, J. S., Sohail, A., Schmidt, S. G., Shi, L., Sitte, H. H., Gether, U. & Loland, C. J., 28 sep. 2016, I: Nature Communications. 7, 12 s., 12755.

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  • Plasma Membrane Neurotransmitter Transport Proteins 100%
  • neurotransmitters 78%
  • transporter 75%
  • Fluorescence Resonance Energy Transfer 70%
  • resonance fluorescence 62%
  18 Citationer (Scopus)

  100 Downloads (Pure)
• 2015

  Substrate-induced Unlocking of the Inner Gate Determines the Catalytic Efficiency of a Neurotransmitter: Sodium Symporter

  Billesbolle, C. B., Kruger, M. B., Shi, L., Quick, M., Li, Z., Stolzenberg, S., Kniazeff, J., Gotfryd, K., Mortensen, J. S., Javitch, J. A., Weinstein, H., Loland, C. J. & Gether, U., 30 okt. 2015, I: Journal of Biological Chemistry. 290, 44, s. 26725-26738 14 s.

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  • Plasma Membrane Neurotransmitter Transport Proteins 100%
  • Neurotransmitter 58%
  • Fluorescence Spectrometry 33%
  • Sodium Atom 33%
  • Lipid Bilayers 31%
  25 Citationer (Scopus)