YKL-40 levels and atrial fibrillation in the general population

Sarah C W Marott; Marianne Benn; Julia S Johansen; Gorm B Jensen; Anne Tybjærg-Hansen; Børge G Nordestgaard

doi:10.1016/j.ijcard.2012.04.006

YKL-40 levels and atrial fibrillation in the general population

Sarah C W Marott, Marianne Benn, Julia S Johansen, Gorm B Jensen, Anne Tybjærg-Hansen, Børge G Nordestgaard

19 Citations (Scopus)

Abstract

BACKGROUND: Atrial fibrillation is associated with inflammation. In contrast to inflammatory markers like C-reactive protein (CRP) and fibrinogen produced in the liver, YKL-40 is produced at the site of inflammation including in the myocardium. We hypothesized that elevated plasma YKL-40 levels associate with increased risk of atrial fibrillation. METHOD AND RESULTS: We measured plasma YKL-40 in 8731 participants from the prospective Copenhagen City Heart Study including 896 individuals who developed atrial fibrillation during up to 18years of follow-up. Additionally, we measured YKL-40 in 6621 individuals from the cross-sectional Copenhagen General Population Study including 337 cases with atrial fibrillation. A YKL-40 level >95% percentile (>204μg/L) versus 95% percentile versus

Original language	English
Journal	International Journal of Cardiology
ISSN	0167-5273
DOIs	https://doi.org/10.1016/j.ijcard.2012.04.006
Publication status	Published - 20 Aug 2013

Access to Document

10.1016/j.ijcard.2012.04.006

Cite this

@article{8f68beaecd1343c99a632dfcf6f2f647,

title = "YKL-40 levels and atrial fibrillation in the general population",

abstract = "BACKGROUND: Atrial fibrillation is associated with inflammation. In contrast to inflammatory markers like C-reactive protein (CRP) and fibrinogen produced in the liver, YKL-40 is produced at the site of inflammation including in the myocardium. We hypothesized that elevated plasma YKL-40 levels associate with increased risk of atrial fibrillation. METHOD AND RESULTS: We measured plasma YKL-40 in 8731 participants from the prospective Copenhagen City Heart Study including 896 individuals who developed atrial fibrillation during up to 18years of follow-up. Additionally, we measured YKL-40 in 6621 individuals from the cross-sectional Copenhagen General Population Study including 337 cases with atrial fibrillation. A YKL-40 level >95% percentile (>204μg/L) versus 95% percentile versus",

author = "Marott, {Sarah C W} and Marianne Benn and Johansen, {Julia S} and Jensen, {Gorm B} and Anne Tybj{\ae}rg-Hansen and Nordestgaard, {B{\o}rge G}",

year = "2013",

month = aug,

day = "20",

doi = "10.1016/j.ijcard.2012.04.006",

language = "English",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - YKL-40 levels and atrial fibrillation in the general population

AU - Marott, Sarah C W

AU - Benn, Marianne

AU - Johansen, Julia S

AU - Jensen, Gorm B

AU - Tybjærg-Hansen, Anne

AU - Nordestgaard, Børge G

PY - 2013/8/20

Y1 - 2013/8/20

N2 - BACKGROUND: Atrial fibrillation is associated with inflammation. In contrast to inflammatory markers like C-reactive protein (CRP) and fibrinogen produced in the liver, YKL-40 is produced at the site of inflammation including in the myocardium. We hypothesized that elevated plasma YKL-40 levels associate with increased risk of atrial fibrillation. METHOD AND RESULTS: We measured plasma YKL-40 in 8731 participants from the prospective Copenhagen City Heart Study including 896 individuals who developed atrial fibrillation during up to 18years of follow-up. Additionally, we measured YKL-40 in 6621 individuals from the cross-sectional Copenhagen General Population Study including 337 cases with atrial fibrillation. A YKL-40 level >95% percentile (>204μg/L) versus 95% percentile versus

AB - BACKGROUND: Atrial fibrillation is associated with inflammation. In contrast to inflammatory markers like C-reactive protein (CRP) and fibrinogen produced in the liver, YKL-40 is produced at the site of inflammation including in the myocardium. We hypothesized that elevated plasma YKL-40 levels associate with increased risk of atrial fibrillation. METHOD AND RESULTS: We measured plasma YKL-40 in 8731 participants from the prospective Copenhagen City Heart Study including 896 individuals who developed atrial fibrillation during up to 18years of follow-up. Additionally, we measured YKL-40 in 6621 individuals from the cross-sectional Copenhagen General Population Study including 337 cases with atrial fibrillation. A YKL-40 level >95% percentile (>204μg/L) versus 95% percentile versus

U2 - 10.1016/j.ijcard.2012.04.006

DO - 10.1016/j.ijcard.2012.04.006

M3 - Journal article

C2 - 22525348

SN - 0167-5273

JO - International Journal of Cardiology

JF - International Journal of Cardiology

ER -

YKL-40 levels and atrial fibrillation in the general population

Abstract

Access to Document

Fingerprint

Cite this