Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116 000 European men and women

Katriina Heikkil�; Solja T Nyberg; T�res Theorell; Eleonor I Fransson; Lars Alfredsson; Jakob B Bjorner; S�bastien Bonenfant; Marianne Borritz; Kim Bouillon; Herman Burr; Nico Dragano; Goedele A Geuskens; Marcel Goldberg; Mark Hamer; Wendela E Hooftman; Irene L Houtman; Matti Joensuu; Anders Knutsson; Markku Koskenvuo; Aki Koskinen; Anne Kouvonen; Ida Elisabeth Huitfeldt Madsen; Linda L Magnusson Hanson; Michael G Marmot; Martin L. Nielsen; Maria Nordin; Tuula Oksanen; Jaana Pentti; Paula Salo; Reiner Ernst Rugulies; Andrew Steptoe; Sakari Suominen; Jussi Vahtera; Marianna Virtanen; Ari V��n�nen; Peter Westerholm; Hugo Westerlund; Marie Zins; Jane E Ferrie; Archana Singh-Manoux; George David Batty; Mika Kivim�ki; IPD-Work Consortium

doi:10.1136/bmj.f165

Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116 000 European men and women

Katriina Heikkil�, Solja T Nyberg, T�res Theorell, Eleonor I Fransson, Lars Alfredsson, Jakob B Bjorner, S�bastien Bonenfant, Marianne Borritz, Kim Bouillon, Herman Burr, Nico Dragano, Goedele A Geuskens, Marcel Goldberg, Mark Hamer, Wendela E Hooftman, Irene L Houtman, Matti Joensuu, Anders Knutsson, Markku Koskenvuo, Aki KoskinenAnne Kouvonen, Ida Elisabeth Huitfeldt Madsen, Linda L Magnusson Hanson, Michael G Marmot, Martin L. Nielsen, Maria Nordin, Tuula Oksanen, Jaana Pentti, Paula Salo, Reiner Ernst Rugulies, Andrew Steptoe, Sakari Suominen, Jussi Vahtera, Marianna Virtanen, Ari V��n�nen, Peter Westerholm, Hugo Westerlund, Marie Zins, Jane E Ferrie, Archana Singh-Manoux, George David Batty, Mika Kivim�ki, IPD-Work Consortium

Section of Social Medicine

87 Citations (Scopus)

Abstract

Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake Results A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer. Conclusions These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers.

Original language	Undefined/Unknown
Article number	f165
Journal	B M J (Online)
Volume	346
Number of pages	10
ISSN	1756-1833
DOIs	https://doi.org/10.1136/bmj.f165
Publication status	Published - 23 Feb 2013

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Heikkil�, K., Nyberg, S. T., Theorell, T., Fransson, E. I., Alfredsson, L., Bjorner, J. B., Bonenfant, S., Borritz, M., Bouillon, K., Burr, H., Dragano, N., Geuskens, G. A., Goldberg, M., Hamer, M., Hooftman, W. E., Houtman, I. L., Joensuu, M., Knutsson, A., Koskenvuo, M., ... Consortium, IPD-W. (2013). Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116 000 European men and women. B M J (Online), 346, [f165]. https://doi.org/10.1136/bmj.f165

Heikkil�, K, Nyberg, ST, Theorell, T, Fransson, EI, Alfredsson, L, Bjorner, JB, Bonenfant, S, Borritz, M, Bouillon, K, Burr, H, Dragano, N, Geuskens, GA, Goldberg, M, Hamer, M, Hooftman, WE, Houtman, IL, Joensuu, M, Knutsson, A, Koskenvuo, M, Koskinen, A, Kouvonen, A, Madsen, IEH, Magnusson Hanson, LL, Marmot, MG, Nielsen, ML, Nordin, M, Oksanen, T, Pentti, J, Salo, P, Rugulies, RE, Steptoe, A, Suominen, S, Vahtera, J, Virtanen, M, V��n�nen, A, Westerholm, P, Westerlund, H, Zins, M, Ferrie, JE, Singh-Manoux, A, Batty, GD, Kivim�ki, M & Consortium, IPD-W 2013, 'Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116 000 European men and women', B M J (Online), vol. 346, f165. https://doi.org/10.1136/bmj.f165

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title = "Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116 000 European men and women",

abstract = "Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake Results A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer. Conclusions These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers.",

author = "Katriina Heikkil� and Nyberg, {Solja T} and T�res Theorell and Fransson, {Eleonor I} and Lars Alfredsson and Bjorner, {Jakob B} and S�bastien Bonenfant and Marianne Borritz and Kim Bouillon and Herman Burr and Nico Dragano and Geuskens, {Goedele A} and Marcel Goldberg and Mark Hamer and Hooftman, {Wendela E} and Houtman, {Irene L} and Matti Joensuu and Anders Knutsson and Markku Koskenvuo and Aki Koskinen and Anne Kouvonen and Madsen, {Ida Elisabeth Huitfeldt} and {Magnusson Hanson}, {Linda L} and Marmot, {Michael G} and Nielsen, {Martin L.} and Maria Nordin and Tuula Oksanen and Jaana Pentti and Paula Salo and Rugulies, {Reiner Ernst} and Andrew Steptoe and Sakari Suominen and Jussi Vahtera and Marianna Virtanen and Ari V��n�nen and Peter Westerholm and Hugo Westerlund and Marie Zins and Ferrie, {Jane E} and Archana Singh-Manoux and Batty, {George David} and Mika Kivim�ki and IPD-Work Consortium",

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T1 - Work stress and risk of cancer

T2 - meta-analysis of 5700 incident cancer events in 116 000 European men and women

AU - Heikkil�, Katriina

AU - Nyberg, Solja T

AU - Theorell, T�res

AU - Fransson, Eleonor I

AU - Alfredsson, Lars

AU - Bjorner, Jakob B

AU - Bonenfant, S�bastien

AU - Borritz, Marianne

AU - Bouillon, Kim

AU - Burr, Herman

AU - Dragano, Nico

AU - Geuskens, Goedele A

AU - Goldberg, Marcel

AU - Hamer, Mark

AU - Hooftman, Wendela E

AU - Houtman, Irene L

AU - Joensuu, Matti

AU - Knutsson, Anders

AU - Koskenvuo, Markku

AU - Koskinen, Aki

AU - Kouvonen, Anne

AU - Madsen, Ida Elisabeth Huitfeldt

AU - Magnusson Hanson, Linda L

AU - Marmot, Michael G

AU - Nielsen, Martin L.

AU - Nordin, Maria

AU - Oksanen, Tuula

AU - Pentti, Jaana

AU - Salo, Paula

AU - Rugulies, Reiner Ernst

AU - Steptoe, Andrew

AU - Suominen, Sakari

AU - Vahtera, Jussi

AU - Virtanen, Marianna

AU - V��n�nen, Ari

AU - Westerholm, Peter

AU - Westerlund, Hugo

AU - Zins, Marie

AU - Ferrie, Jane E

AU - Singh-Manoux, Archana

AU - Batty, George David

AU - Kivim�ki, Mika

AU - Consortium, IPD-Work

PY - 2013/2/23

Y1 - 2013/2/23

N2 - Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake Results A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer. Conclusions These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers.

AB - Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake Results A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer. Conclusions These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers.

U2 - 10.1136/bmj.f165

DO - 10.1136/bmj.f165

M3 - Tidsskriftartikel

SN - 0959-8146

VL - 346

JO - BMJ

JF - BMJ

M1 - f165

ER -