Abstract
Objectives: A low vitamin D level has been associated with increased cardiovascular disease risk but possible mechanisms remain unclear. We investigated the association between vitamin D levels and 5-year changes in blood pressure, lipid profile and incidence of the metabolic syndrome, hypertension and hypercholesterolemia. Methods: A random sample of 6,784 individuals aged 30-60 years from a general population was investigated in the Inter99 study in 1999-2001. Vitamin D (serum 25-hydroxyvitamin D) was measured at baseline by high-performance liquid chromatography, and 4,330 individuals participated at the 5-year follow-up and were included in the present study. Results: The median baseline vitamin D concentration was 48.0 nmol/l. In multivariable linear regression analyses, a 10 nmol/l higher baseline level of vitamin D was associated with a decrease in triglycerides and very low density lipoprotein cholesterol by 0.52 (p = 0.03) and 0.66% (p = 0.005), respectively. In multivariable logistic regression analyses, the odds ratios per 10 nmol/l higher baseline vitamin D level were 0.95 (p < 0.05) and 0.94 (p = 0.01) for the development of the metabolic syndrome and hypercholesterolemia, respectively. There was no association between vitamin D and blood pressure. Conclusions: An optimal vitamin D status may influence cardiovascular health by changing the lipid profile in a favorable direction and decreasing the incidence of the metabolic syndrome.
| Original language | English |
|---|---|
| Journal | The Cardiology |
| Volume | 123 |
| Issue number | 1 |
| Pages (from-to) | 62-70 |
| Number of pages | 9 |
| ISSN | 1811-8194 |
| DOIs | |
| Publication status | Published - Sept 2012 |
Keywords
- Adult
- Blood Pressure
- Chromatography, Liquid
- Female
- Follow-Up Studies
- Humans
- Hypercholesterolemia
- Hypertension
- Incidence
- Lipids
- Male
- Metabolic Syndrome X
- Middle Aged
- Prospective Studies
- Risk Factors
- Vitamin D
- Vitamin D Deficiency
