Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries

Jakob Damsgaard; Ulla N Joensen; Elisabeth Carlsen; Juris Erenpreiss; Martin Blomberg Jensen; Valentinas Matulevicius; Birute Zilaitiene; Inge A Olesen; Antti Perheentupa; Margus Punab; Andrea Salzbrunn; Jorma Toppari; Helena E. Virtanen; Anders Juul; Niels E Skakkebæk; Niels Jørgensen

doi:10.1016/j.eururo.2016.06.044

Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries

Jakob Damsgaard, Ulla N Joensen, Elisabeth Carlsen, Juris Erenpreiss, Martin Blomberg Jensen, Valentinas Matulevicius, Birute Zilaitiene, Inge A Olesen, Antti Perheentupa, Margus Punab, Andrea Salzbrunn, Jorma Toppari, Helena E. Virtanen, Anders Juul, Niels E Skakkebæk, Niels Jørgensen

Department of Clinical Medicine

89 Citations (Scopus)

Abstract

BACKGROUND: Present knowledge on the impact of varicoceles on testicular function is largely based on studies of subfertile and infertile men, making it difficult to extrapolate the impact of varicocele on the general population.

OBJECTIVE: To describe associations between varicocele and testicular function assessed by semen analysis and reproductive hormones in men from the general population.

DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional multicentre study of 7035 young men, median age 19 yr, from the general population in six European countries (Denmark, Finland, Germany, Estonia, Latvia, and Lithuania) were investigated from 1996 to 2010.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We analysed results from physical examination, conventional semen variables, and serum reproductive hormones using multivariable regression analyses.

RESULTS AND LIMITATIONS: A total of 1102 (15.7%) had grade 1-3 varicocele. Increasing varicocele grade was associated with poorer semen quality, even in grade 1 varicocele. In grade 3 varicocele, sperm concentration was less than half of that in men with no varicocele. Presence of varicocele was also associated with higher serum levels of follicle-stimulating hormone, lower inhibin B, and higher levels of luteinising hormone; testosterone and free testosterone were not significantly different between men with and without varicocele. This study cannot draw a conclusion on the progressiveness of varicocele or the effect of treatment.

CONCLUSIONS: We demonstrated an adverse effect of increasing grade of varicocele on testicular function in men not selected due to fertility status.

PATIENT SUMMARY: The presence and increasing grade of varicocele is adversely associated with semen quality and reproductive hormone levels in young men from the general population.

Original language	English
Journal	European Urology
Volume	70
Issue number	6
Pages (from-to)	1019-1029
Number of pages	11
ISSN	0302-2838
DOIs	https://doi.org/10.1016/j.eururo.2016.06.044
Publication status	Published - 1 Dec 2016

Keywords

Journal Article

Access to Document

10.1016/j.eururo.2016.06.044

Cite this

Damsgaard, J., Joensen, U. N., Carlsen, E., Erenpreiss, J., Jensen, M. B., Matulevicius, V., Zilaitiene, B., Olesen, I. A., Perheentupa, A., Punab, M., Salzbrunn, A., Toppari, J., Virtanen, H. E., Juul, A., Skakkebæk, N. E., & Jørgensen, N. (2016). Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. European Urology, 70(6), 1019-1029. https://doi.org/10.1016/j.eururo.2016.06.044

Damsgaard, J, Joensen, UN, Carlsen, E, Erenpreiss, J, Jensen, MB, Matulevicius, V, Zilaitiene, B, Olesen, IA, Perheentupa, A, Punab, M, Salzbrunn, A, Toppari, J, Virtanen, HE, Juul, A , Skakkebæk, NE & Jørgensen, N 2016, 'Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries', European Urology, vol. 70, no. 6, pp. 1019-1029. https://doi.org/10.1016/j.eururo.2016.06.044

@article{a3148e499b7d4ed99253ff98cd0461e9,

title = "Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries",

abstract = "BACKGROUND: Present knowledge on the impact of varicoceles on testicular function is largely based on studies of subfertile and infertile men, making it difficult to extrapolate the impact of varicocele on the general population.OBJECTIVE: To describe associations between varicocele and testicular function assessed by semen analysis and reproductive hormones in men from the general population.DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional multicentre study of 7035 young men, median age 19 yr, from the general population in six European countries (Denmark, Finland, Germany, Estonia, Latvia, and Lithuania) were investigated from 1996 to 2010.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We analysed results from physical examination, conventional semen variables, and serum reproductive hormones using multivariable regression analyses.RESULTS AND LIMITATIONS: A total of 1102 (15.7%) had grade 1-3 varicocele. Increasing varicocele grade was associated with poorer semen quality, even in grade 1 varicocele. In grade 3 varicocele, sperm concentration was less than half of that in men with no varicocele. Presence of varicocele was also associated with higher serum levels of follicle-stimulating hormone, lower inhibin B, and higher levels of luteinising hormone; testosterone and free testosterone were not significantly different between men with and without varicocele. This study cannot draw a conclusion on the progressiveness of varicocele or the effect of treatment.CONCLUSIONS: We demonstrated an adverse effect of increasing grade of varicocele on testicular function in men not selected due to fertility status.PATIENT SUMMARY: The presence and increasing grade of varicocele is adversely associated with semen quality and reproductive hormone levels in young men from the general population.",

keywords = "Journal Article",

author = "Jakob Damsgaard and Joensen, {Ulla N} and Elisabeth Carlsen and Juris Erenpreiss and Jensen, {Martin Blomberg} and Valentinas Matulevicius and Birute Zilaitiene and Olesen, {Inge A} and Antti Perheentupa and Margus Punab and Andrea Salzbrunn and Jorma Toppari and Virtanen, {Helena E.} and Anders Juul and Skakkeb{\ae}k, {Niels E} and Niels J{\o}rgensen",

year = "2016",

month = dec,

day = "1",

doi = "10.1016/j.eururo.2016.06.044",

language = "English",

volume = "70",

pages = "1019--1029",

journal = "European Urology",

issn = "0302-2838",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels

T2 - A Study of 7035 Healthy Young Men from Six European Countries

AU - Damsgaard, Jakob

AU - Joensen, Ulla N

AU - Carlsen, Elisabeth

AU - Erenpreiss, Juris

AU - Jensen, Martin Blomberg

AU - Matulevicius, Valentinas

AU - Zilaitiene, Birute

AU - Olesen, Inge A

AU - Perheentupa, Antti

AU - Punab, Margus

AU - Salzbrunn, Andrea

AU - Toppari, Jorma

AU - Virtanen, Helena E.

AU - Juul, Anders

AU - Skakkebæk, Niels E

AU - Jørgensen, Niels

PY - 2016/12/1

Y1 - 2016/12/1

N2 - BACKGROUND: Present knowledge on the impact of varicoceles on testicular function is largely based on studies of subfertile and infertile men, making it difficult to extrapolate the impact of varicocele on the general population.OBJECTIVE: To describe associations between varicocele and testicular function assessed by semen analysis and reproductive hormones in men from the general population.DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional multicentre study of 7035 young men, median age 19 yr, from the general population in six European countries (Denmark, Finland, Germany, Estonia, Latvia, and Lithuania) were investigated from 1996 to 2010.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We analysed results from physical examination, conventional semen variables, and serum reproductive hormones using multivariable regression analyses.RESULTS AND LIMITATIONS: A total of 1102 (15.7%) had grade 1-3 varicocele. Increasing varicocele grade was associated with poorer semen quality, even in grade 1 varicocele. In grade 3 varicocele, sperm concentration was less than half of that in men with no varicocele. Presence of varicocele was also associated with higher serum levels of follicle-stimulating hormone, lower inhibin B, and higher levels of luteinising hormone; testosterone and free testosterone were not significantly different between men with and without varicocele. This study cannot draw a conclusion on the progressiveness of varicocele or the effect of treatment.CONCLUSIONS: We demonstrated an adverse effect of increasing grade of varicocele on testicular function in men not selected due to fertility status.PATIENT SUMMARY: The presence and increasing grade of varicocele is adversely associated with semen quality and reproductive hormone levels in young men from the general population.

AB - BACKGROUND: Present knowledge on the impact of varicoceles on testicular function is largely based on studies of subfertile and infertile men, making it difficult to extrapolate the impact of varicocele on the general population.OBJECTIVE: To describe associations between varicocele and testicular function assessed by semen analysis and reproductive hormones in men from the general population.DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional multicentre study of 7035 young men, median age 19 yr, from the general population in six European countries (Denmark, Finland, Germany, Estonia, Latvia, and Lithuania) were investigated from 1996 to 2010.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We analysed results from physical examination, conventional semen variables, and serum reproductive hormones using multivariable regression analyses.RESULTS AND LIMITATIONS: A total of 1102 (15.7%) had grade 1-3 varicocele. Increasing varicocele grade was associated with poorer semen quality, even in grade 1 varicocele. In grade 3 varicocele, sperm concentration was less than half of that in men with no varicocele. Presence of varicocele was also associated with higher serum levels of follicle-stimulating hormone, lower inhibin B, and higher levels of luteinising hormone; testosterone and free testosterone were not significantly different between men with and without varicocele. This study cannot draw a conclusion on the progressiveness of varicocele or the effect of treatment.CONCLUSIONS: We demonstrated an adverse effect of increasing grade of varicocele on testicular function in men not selected due to fertility status.PATIENT SUMMARY: The presence and increasing grade of varicocele is adversely associated with semen quality and reproductive hormone levels in young men from the general population.

KW - Journal Article

U2 - 10.1016/j.eururo.2016.06.044

DO - 10.1016/j.eururo.2016.06.044

M3 - Journal article

C2 - 27423503

SN - 0302-2838

VL - 70

SP - 1019

EP - 1029

JO - European Urology

JF - European Urology

IS - 6

ER -

Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries

Abstract

Keywords

Access to Document

Fingerprint

Cite this