Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients

Gitte Kronborg; Nina Weis; Hans O Madsen; Svend S Pedersen; Christian Wejse; Henrik Nielsen; Peter Skinhøj; Peter Garred; Nina Weis

doi:10.1086/340216

Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients

Gitte Kronborg, Nina Weis, Hans O Madsen, Svend S Pedersen, Christian Wejse, Henrik Nielsen, Peter Skinhøj, Peter Garred, Nina Weis

Department of Clinical Medicine

97 Citations (Scopus)

Abstract

Invasive pneumococcal disease is a serious infection that primarily affects very young children and elderly or immunocompromised individuals but also affects previously healthy people. Variant mannose-binding lectin (MBL) alleles are associated with recurrent infections and may be a risk factor for pneumococcal infections. To assess the influence of MBL genotypes on the course and outcome of invasive pneumococcal disease, clinical data for 141 adult patients were collected prospectively and their genotypes were determined. All patients included had positive blood cultures for Streptococcus pneumoniae. The distribution of variant MBL alleles related to low MBL serum concentrations was similar among the patients and healthy individuals, and MBL genotype was not associated with infection outcome. Thus, in a random adult population with invasive pneumococcal infection, MBL does not seem to play a role in the pathophysiology, in contrast to earlier observations in patients with other concomitant immune abnormalities.

Original language	English
Journal	Journal of Infectious Diseases
Volume	185
Issue number	10
Pages (from-to)	1517-20
Number of pages	3
ISSN	0022-1899
DOIs	https://doi.org/10.1086/340216 https://doi.org/10.1086/340216
Publication status	Published - 2002

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Kronborg, G., Weis, N., Madsen, H. O., Pedersen, S. S., Wejse, C., Nielsen, H., Skinhøj, P., Garred, P., & Weis, N. (2002). Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. Journal of Infectious Diseases, 185(10), 1517-20. https://doi.org/10.1086/340216, https://doi.org/10.1086/340216

Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients. / Kronborg, Gitte; Weis, Nina; Madsen, Hans O et al.

In: Journal of Infectious Diseases, Vol. 185, No. 10, 2002, p. 1517-20.

Research output: Contribution to journal › Journal article › Research › peer-review

Kronborg, G, Weis, N, Madsen, HO, Pedersen, SS, Wejse, C, Nielsen, H, Skinhøj, P, Garred, P & Weis, N 2002, 'Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients', Journal of Infectious Diseases, vol. 185, no. 10, pp. 1517-20. https://doi.org/10.1086/340216, https://doi.org/10.1086/340216

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abstract = "Invasive pneumococcal disease is a serious infection that primarily affects very young children and elderly or immunocompromised individuals but also affects previously healthy people. Variant mannose-binding lectin (MBL) alleles are associated with recurrent infections and may be a risk factor for pneumococcal infections. To assess the influence of MBL genotypes on the course and outcome of invasive pneumococcal disease, clinical data for 141 adult patients were collected prospectively and their genotypes were determined. All patients included had positive blood cultures for Streptococcus pneumoniae. The distribution of variant MBL alleles related to low MBL serum concentrations was similar among the patients and healthy individuals, and MBL genotype was not associated with infection outcome. Thus, in a random adult population with invasive pneumococcal infection, MBL does not seem to play a role in the pathophysiology, in contrast to earlier observations in patients with other concomitant immune abnormalities.",

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AU - Kronborg, Gitte

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AU - Wejse, Christian

AU - Nielsen, Henrik

AU - Skinhøj, Peter

AU - Garred, Peter

AU - Weis, Nina

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N2 - Invasive pneumococcal disease is a serious infection that primarily affects very young children and elderly or immunocompromised individuals but also affects previously healthy people. Variant mannose-binding lectin (MBL) alleles are associated with recurrent infections and may be a risk factor for pneumococcal infections. To assess the influence of MBL genotypes on the course and outcome of invasive pneumococcal disease, clinical data for 141 adult patients were collected prospectively and their genotypes were determined. All patients included had positive blood cultures for Streptococcus pneumoniae. The distribution of variant MBL alleles related to low MBL serum concentrations was similar among the patients and healthy individuals, and MBL genotype was not associated with infection outcome. Thus, in a random adult population with invasive pneumococcal infection, MBL does not seem to play a role in the pathophysiology, in contrast to earlier observations in patients with other concomitant immune abnormalities.

AB - Invasive pneumococcal disease is a serious infection that primarily affects very young children and elderly or immunocompromised individuals but also affects previously healthy people. Variant mannose-binding lectin (MBL) alleles are associated with recurrent infections and may be a risk factor for pneumococcal infections. To assess the influence of MBL genotypes on the course and outcome of invasive pneumococcal disease, clinical data for 141 adult patients were collected prospectively and their genotypes were determined. All patients included had positive blood cultures for Streptococcus pneumoniae. The distribution of variant MBL alleles related to low MBL serum concentrations was similar among the patients and healthy individuals, and MBL genotype was not associated with infection outcome. Thus, in a random adult population with invasive pneumococcal infection, MBL does not seem to play a role in the pathophysiology, in contrast to earlier observations in patients with other concomitant immune abnormalities.

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Variant mannose-binding lectin alleles are not associated with susceptibility to or outcome of invasive pneumococcal infection in randomly included patients

Abstract

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