Ubiquitin binding proteins protect ubiquitin conjugates from disassembly.

TY - JOUR

T1 - Ubiquitin binding proteins protect ubiquitin conjugates from disassembly.

AU - Hartmann-Petersen, Rasmus

AU - Hendil, Klavs B

AU - Gordon, Colin

N1 - Keywords: Amino Acid Motifs; Carrier Proteins; DNA-Binding Proteins; Fungal Proteins; Macromolecular Substances; Peptide Hydrolases; Proteasome Endopeptidase Complex; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Ubiquitin

PY - 2003

Y1 - 2003

N2 - As a step in their turnover proteins in eukaryotic cells are coupled to a small protein, ubiquitin, before they are recognised by 26S proteasomes and degraded. However, cells also contain many deubiquitinating enzymes, which can rescue proteins by cleaving off the ubiquitin chains. Here we report that three ubiquitin binding proteins, Rhp23, Dph1 and Pus1, from fission yeast can protect multiubiquitin conjugates against deubiquitination. This protection depends on the ubiquitin binding domains and may promote degradation of ubiquitinated proteins.

AB - As a step in their turnover proteins in eukaryotic cells are coupled to a small protein, ubiquitin, before they are recognised by 26S proteasomes and degraded. However, cells also contain many deubiquitinating enzymes, which can rescue proteins by cleaving off the ubiquitin chains. Here we report that three ubiquitin binding proteins, Rhp23, Dph1 and Pus1, from fission yeast can protect multiubiquitin conjugates against deubiquitination. This protection depends on the ubiquitin binding domains and may promote degradation of ubiquitinated proteins.

U2 - 10.1016/S0014-5793(02)03874-7

DO - 10.1016/S0014-5793(02)03874-7

M3 - Journal article

C2 - 12560082

SN - 0014-5793

VL - 535

SP - 77

EP - 81

JO - F E B S Letters

JF - F E B S Letters

IS - 1-3

ER -