TOPping up ATR activity

TY - JOUR

T1 - TOPping up ATR activity

AU - Bartek, Jiri

AU - Mailand, Niels

PY - 2006/3/10

Y1 - 2006/3/10

N2 - The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

AB - The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.

KW - Animals

KW - Ataxia Telangiectasia Mutated Proteins

KW - Carrier Proteins

KW - Cell Cycle Proteins

KW - DNA Repair

KW - DNA-Binding Proteins

KW - Enzyme Activation

KW - Gene Expression Regulation

KW - Humans

KW - Models, Genetic

KW - Nuclear Proteins

KW - Protein-Serine-Threonine Kinases

KW - Xenopus Proteins

U2 - 10.1016/j.cell.2006.02.029

DO - 10.1016/j.cell.2006.02.029

M3 - Comment/debate

C2 - 16530035

SN - 0092-8674

VL - 124

SP - 888

EP - 890

JO - Cell

JF - Cell

IS - 5

ER -