The prognostic value of dividing epithelial ovarian cancer into type I and type II tumors based on pathologic characteristics

Kira Philipsen Prahm; Mona Aarenstrup Karlsen; Estrid Høgdall; Nikolai Madrid Scheller; Lene Lundvall; Lotte Nedergaard; Ib Jarle Christensen; Claus Høgdall

doi:10.1016/j.ygyno.2014.12.029

The prognostic value of dividing epithelial ovarian cancer into type I and type II tumors based on pathologic characteristics

Kira Philipsen Prahm, Mona Aarenstrup Karlsen, Estrid Høgdall, Nikolai Madrid Scheller, Lene Lundvall, Lotte Nedergaard, Ib Jarle Christensen, Claus Høgdall

19 Citations (Scopus)

Abstract

Objective. To investigate the prognostic significance of dividing epithelial ovarian cancer (EOC) in type I and type II tumors based on pathologic variables. Methods. We used the Danish Gynecologic Cancer Database to identify all patients diagnosed with EOC from 2005 to 2012. Information on histologic type and grade were used to classify tumors as either type I or type II. Death, and several prognostic factors were used in the multivariate Cox regression, and Landmark analysis was used to estimate hazard ratios of all-cause mortality. Results. Among 2660 patients diagnosed with EOC, 735 were categorized as type I tumors, and 1925 as type II tumors. Patients with type II EOC were more frequently diagnosed in late FIGO stages (stages III-IV) than patients with type I EOC (78.1% vs. 32.1% respectively; P < 0.001). Time dependent multivariate Cox analysis, adjusted for known prognostic variables, showed no significant difference in survival within the first two years after diagnosis, however, after 730 days of follow-up a significantly increased overall survival for type I tumors was observed (hazard ratio 1.72, 95% confidence interval: 1.28-2.31, P < 0.001). Similarly the Landmark analysis for survival confirmed the increased overall survival for type I tumors after two years of follow-up (hazard ratio: 1.85, 95% confidence interval: 1.35-2.54, P < 0.001). Conclusion. Classification of EOC in type I and type II tumors based on pathologic variables was associated with an increased risk of death for type II tumors after two years of follow-up, while no increased risk was seen during the first two years of follow-up.

Original language	English
Journal	Gynecologic Oncology
Volume	136
Issue number	2
Pages (from-to)	205-11
Number of pages	7
ISSN	0090-8258
DOIs	https://doi.org/10.1016/j.ygyno.2014.12.029
Publication status	Published - 1 Feb 2015

Keywords

Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Middle Aged
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Prognosis
Survival Analysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ygyno.2014.12.029

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@article{056e71efc23841edb674f3b8eb76b5cc,

title = "The prognostic value of dividing epithelial ovarian cancer into type I and type II tumors based on pathologic characteristics",

abstract = "Objective. To investigate the prognostic significance of dividing epithelial ovarian cancer (EOC) in type I and type II tumors based on pathologic variables. Methods. We used the Danish Gynecologic Cancer Database to identify all patients diagnosed with EOC from 2005 to 2012. Information on histologic type and grade were used to classify tumors as either type I or type II. Death, and several prognostic factors were used in the multivariate Cox regression, and Landmark analysis was used to estimate hazard ratios of all-cause mortality. Results. Among 2660 patients diagnosed with EOC, 735 were categorized as type I tumors, and 1925 as type II tumors. Patients with type II EOC were more frequently diagnosed in late FIGO stages (stages III-IV) than patients with type I EOC (78.1% vs. 32.1% respectively; P < 0.001). Time dependent multivariate Cox analysis, adjusted for known prognostic variables, showed no significant difference in survival within the first two years after diagnosis, however, after 730 days of follow-up a significantly increased overall survival for type I tumors was observed (hazard ratio 1.72, 95% confidence interval: 1.28-2.31, P < 0.001). Similarly the Landmark analysis for survival confirmed the increased overall survival for type I tumors after two years of follow-up (hazard ratio: 1.85, 95% confidence interval: 1.35-2.54, P < 0.001). Conclusion. Classification of EOC in type I and type II tumors based on pathologic variables was associated with an increased risk of death for type II tumors after two years of follow-up, while no increased risk was seen during the first two years of follow-up.",

keywords = "Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Middle Aged, Neoplasms, Glandular and Epithelial, Ovarian Neoplasms, Prognosis, Survival Analysis",

author = "Prahm, {Kira Philipsen} and Karlsen, {Mona Aarenstrup} and Estrid H{\o}gdall and Scheller, {Nikolai Madrid} and Lene Lundvall and Lotte Nedergaard and Christensen, {Ib Jarle} and Claus H{\o}gdall",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.ygyno.2014.12.029",

language = "English",

volume = "136",

pages = "205--11",

journal = "Gynecologic Oncology",

issn = "0090-8258",

publisher = "Academic Press",

number = "2",

}

TY - JOUR

T1 - The prognostic value of dividing epithelial ovarian cancer into type I and type II tumors based on pathologic characteristics

AU - Prahm, Kira Philipsen

AU - Karlsen, Mona Aarenstrup

AU - Høgdall, Estrid

AU - Scheller, Nikolai Madrid

AU - Lundvall, Lene

AU - Nedergaard, Lotte

AU - Christensen, Ib Jarle

AU - Høgdall, Claus

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Objective. To investigate the prognostic significance of dividing epithelial ovarian cancer (EOC) in type I and type II tumors based on pathologic variables. Methods. We used the Danish Gynecologic Cancer Database to identify all patients diagnosed with EOC from 2005 to 2012. Information on histologic type and grade were used to classify tumors as either type I or type II. Death, and several prognostic factors were used in the multivariate Cox regression, and Landmark analysis was used to estimate hazard ratios of all-cause mortality. Results. Among 2660 patients diagnosed with EOC, 735 were categorized as type I tumors, and 1925 as type II tumors. Patients with type II EOC were more frequently diagnosed in late FIGO stages (stages III-IV) than patients with type I EOC (78.1% vs. 32.1% respectively; P < 0.001). Time dependent multivariate Cox analysis, adjusted for known prognostic variables, showed no significant difference in survival within the first two years after diagnosis, however, after 730 days of follow-up a significantly increased overall survival for type I tumors was observed (hazard ratio 1.72, 95% confidence interval: 1.28-2.31, P < 0.001). Similarly the Landmark analysis for survival confirmed the increased overall survival for type I tumors after two years of follow-up (hazard ratio: 1.85, 95% confidence interval: 1.35-2.54, P < 0.001). Conclusion. Classification of EOC in type I and type II tumors based on pathologic variables was associated with an increased risk of death for type II tumors after two years of follow-up, while no increased risk was seen during the first two years of follow-up.

AB - Objective. To investigate the prognostic significance of dividing epithelial ovarian cancer (EOC) in type I and type II tumors based on pathologic variables. Methods. We used the Danish Gynecologic Cancer Database to identify all patients diagnosed with EOC from 2005 to 2012. Information on histologic type and grade were used to classify tumors as either type I or type II. Death, and several prognostic factors were used in the multivariate Cox regression, and Landmark analysis was used to estimate hazard ratios of all-cause mortality. Results. Among 2660 patients diagnosed with EOC, 735 were categorized as type I tumors, and 1925 as type II tumors. Patients with type II EOC were more frequently diagnosed in late FIGO stages (stages III-IV) than patients with type I EOC (78.1% vs. 32.1% respectively; P < 0.001). Time dependent multivariate Cox analysis, adjusted for known prognostic variables, showed no significant difference in survival within the first two years after diagnosis, however, after 730 days of follow-up a significantly increased overall survival for type I tumors was observed (hazard ratio 1.72, 95% confidence interval: 1.28-2.31, P < 0.001). Similarly the Landmark analysis for survival confirmed the increased overall survival for type I tumors after two years of follow-up (hazard ratio: 1.85, 95% confidence interval: 1.35-2.54, P < 0.001). Conclusion. Classification of EOC in type I and type II tumors based on pathologic variables was associated with an increased risk of death for type II tumors after two years of follow-up, while no increased risk was seen during the first two years of follow-up.

KW - Aged

KW - Aged, 80 and over

KW - Cohort Studies

KW - Female

KW - Humans

KW - Middle Aged

KW - Neoplasms, Glandular and Epithelial

KW - Ovarian Neoplasms

KW - Prognosis

KW - Survival Analysis

U2 - 10.1016/j.ygyno.2014.12.029

DO - 10.1016/j.ygyno.2014.12.029

M3 - Journal article

C2 - 25546113

SN - 0090-8258

VL - 136

SP - 205

EP - 211

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 2

ER -

The prognostic value of dividing epithelial ovarian cancer into type I and type II tumors based on pathologic characteristics

Abstract

Keywords

UN SDGs

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