The lectin pathway of complement: Advantage or disadvantage in HIV pathogenesis?

Vibe Cecilie Diederich Ballegaard; Anna Karen Haugaard; P Garred; Susanne Dam Nielsen; L Munthe-Fog

doi:10.1016/j.clim.2014.06.002

The lectin pathway of complement: Advantage or disadvantage in HIV pathogenesis?

Vibe Cecilie Diederich Ballegaard, Anna Karen Haugaard, P Garred, Susanne Dam Nielsen, L Munthe-Fog

Department of Clinical Medicine

12 Citations (Scopus)

Abstract

The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV-pathogenesis. It has been demonstrated that MBL is capable of binding and neutralizing HIV and may affect host susceptibility to HIV infection and disease progression. In addition, MBL may cause variations in the host immune response against HIV. Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity.

Original language	English
Journal	Clinical Immunology
Volume	154
Issue number	1
Pages (from-to)	13-25
Number of pages	13
ISSN	1521-6616
DOIs	https://doi.org/10.1016/j.clim.2014.06.002
Publication status	Published - Sept 2014

Keywords

Complement Pathway, Mannose-Binding Lectin
HIV Infections
Humans
Models, Biological
Polymorphism, Genetic

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10.1016/j.clim.2014.06.002

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title = "The lectin pathway of complement: Advantage or disadvantage in HIV pathogenesis?",

abstract = "The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV-pathogenesis. It has been demonstrated that MBL is capable of binding and neutralizing HIV and may affect host susceptibility to HIV infection and disease progression. In addition, MBL may cause variations in the host immune response against HIV. Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity.",

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author = "Ballegaard, {Vibe Cecilie Diederich} and Haugaard, {Anna Karen} and P Garred and Nielsen, {Susanne Dam} and L Munthe-Fog",

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T1 - The lectin pathway of complement

T2 - Advantage or disadvantage in HIV pathogenesis?

AU - Ballegaard, Vibe Cecilie Diederich

AU - Haugaard, Anna Karen

AU - Garred, P

AU - Nielsen, Susanne Dam

AU - Munthe-Fog, L

PY - 2014/9

Y1 - 2014/9

N2 - The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV-pathogenesis. It has been demonstrated that MBL is capable of binding and neutralizing HIV and may affect host susceptibility to HIV infection and disease progression. In addition, MBL may cause variations in the host immune response against HIV. Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity.

AB - The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV-pathogenesis. It has been demonstrated that MBL is capable of binding and neutralizing HIV and may affect host susceptibility to HIV infection and disease progression. In addition, MBL may cause variations in the host immune response against HIV. Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity.

KW - Complement Pathway, Mannose-Binding Lectin

KW - HIV Infections

KW - Humans

KW - Models, Biological

KW - Polymorphism, Genetic

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DO - 10.1016/j.clim.2014.06.002

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The lectin pathway of complement: Advantage or disadvantage in HIV pathogenesis?

Abstract

Keywords

UN SDGs

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