The intensive care medicine research agenda on septic shock

Anders Perner; Anthony C Gordon; Derek C Angus; Francois Lamontagne; Flavia Machado; James A Russell; Jean-Francois Timsit; John C Marshall; John Myburgh; Manu Shankar-Hari; Mervyn Singer

doi:10.1007/s00134-017-4821-1

The intensive care medicine research agenda on septic shock

Anders Perner, Anthony C Gordon, Derek C Angus, Francois Lamontagne, Flavia Machado, James A Russell, Jean-Francois Timsit, John C Marshall, John Myburgh, Manu Shankar-Hari, Mervyn Singer

Department of Clinical Medicine

38 Citations (Scopus)

Abstract

Septic shock remains a global health challenge with millions of cases every year, high rates of mortality and morbidity, impaired quality of life among survivors and relatives, and high resource use both in developed and developing nations. Care and outcomes are improving through organisational initiatives and updated clinical practice guidelines based on clinical research mainly carried out by large collaborative networks. This progress is likely to continue through the collaborative work of the established and merging trials groups in many parts of the world and through refined trial methodology and translational work. In this review, international experts summarize the current position of clinical research in septic shock and propose a research agenda to advance this field.

Original language	English
Journal	Intensive Care Medicine
Volume	43
Issue number	9
Pages (from-to)	1294-1305
ISSN	0342-4642
DOIs	https://doi.org/10.1007/s00134-017-4821-1
Publication status	Published - 1 Sept 2017

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AU - Russell, James A

AU - Timsit, Jean-Francois

AU - Marshall, John C

AU - Myburgh, John

AU - Shankar-Hari, Manu

AU - Singer, Mervyn

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AB - Septic shock remains a global health challenge with millions of cases every year, high rates of mortality and morbidity, impaired quality of life among survivors and relatives, and high resource use both in developed and developing nations. Care and outcomes are improving through organisational initiatives and updated clinical practice guidelines based on clinical research mainly carried out by large collaborative networks. This progress is likely to continue through the collaborative work of the established and merging trials groups in many parts of the world and through refined trial methodology and translational work. In this review, international experts summarize the current position of clinical research in septic shock and propose a research agenda to advance this field.

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The intensive care medicine research agenda on septic shock

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