The impact of the postnatal gut microbiota on animal models

TY - GEN

T1 - The impact of the postnatal gut microbiota on animal models

AU - Hansen, Axel Jacob Kornerup

AU - Ejsing-Duun, Maria

AU - Aasted, Bent

AU - Josephsen, Jytte

AU - Christensen, Gitte Bach

AU - Dahl, Kirsten

AU - Vogensen, Finn Kvist

AU - Hufeldt, Majbritt Ravn

AU - Buschard, Karsten Stig

N1 - Conference code: 10

PY - 2007

Y1 - 2007

N2 - Quality control of laboratory animals has been mostly concentrated on eliminating and securing the absence of specific infections, but event barrier bred laboratory animals harbour a huge number of gut bacteria. There is scientific evidence that the nature of the gut microbiota especially in early life - has an impact on the maturation of the immune system and thereby on the development of inflammatory deseases. In several studies, the prevalence of diseases such as rheumatic arthititis (RA), allergies, inflammatory bowel disease (IBD) an type 1 diabetes (T1D) has been shown to be positively correlated to factors related to early exposure to microorganisms, e.g. the so-called hygiene hypothesis claims that the increasing human incidence of allergy. T1D, RA and IBD may be due to the lack of such exposure. It is possible today by various molecular techniques to profile the gut microbiota of a laboratory animal, and such techniques should be applied to document uniform animals from laboratory animal vendors to secure standardization and thereby lower variation and smaller group sizes.

AB - Quality control of laboratory animals has been mostly concentrated on eliminating and securing the absence of specific infections, but event barrier bred laboratory animals harbour a huge number of gut bacteria. There is scientific evidence that the nature of the gut microbiota especially in early life - has an impact on the maturation of the immune system and thereby on the development of inflammatory deseases. In several studies, the prevalence of diseases such as rheumatic arthititis (RA), allergies, inflammatory bowel disease (IBD) an type 1 diabetes (T1D) has been shown to be positively correlated to factors related to early exposure to microorganisms, e.g. the so-called hygiene hypothesis claims that the increasing human incidence of allergy. T1D, RA and IBD may be due to the lack of such exposure. It is possible today by various molecular techniques to profile the gut microbiota of a laboratory animal, and such techniques should be applied to document uniform animals from laboratory animal vendors to secure standardization and thereby lower variation and smaller group sizes.

M3 - Conference article

SN - 0023-6772

SP - 95

EP - 99

JO - Laboratory Animals

JF - Laboratory Animals

T2 - FELASA Symposium and the XIV ICLAS General Assembly & Conference

Y2 - 11 June 2007 through 14 June 2007

ER -