The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency

Morten Aa Petersen; Neil K Aaronson; Juan I Arraras; Wei-Chu Chie; Thierry Conroy; Anna Costantini; Johannes M Giesinger; Bernhard Holzner; Madeleine T King; Susanne Singer; Galina Velikova; Irma M Verdonck-de Leeuw; Teresa Young; Mogens Grønvold; EORTC Quality of Life Group

doi:10.1016/j.jclinepi.2012.09.010

The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency

Morten Aa Petersen, Neil K Aaronson, Juan I Arraras, Wei-Chu Chie, Thierry Conroy, Anna Costantini, Johannes M Giesinger, Bernhard Holzner, Madeleine T King, Susanne Singer, Galina Velikova, Irma M Verdonck-de Leeuw, Teresa Young, Mogens Grønvold, EORTC Quality of Life Group

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Abstract

Objectives: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group is developing a computer-adaptive test (CAT) version of the EORTC Quality of Life Questionnaire (QLQ-C30). We evaluated the measurement properties of the CAT versions of physical functioning (PF) and fatigue (FA) and compared these with the corresponding QLQ-C30 scales. Study Design and Setting: Based on international samples of more than 1,000 cancer patients, we simulated CAT administration of varying numbers of items and compared the resulting scores with those based on all items in the respective item pools. Furthermore, the relative validity (RV) of CATs was compared with that of the QLQ-C30 scales using known groups validity. Results: For both dimensions, CATs of all lengths resulted in unbiased score estimates. CATs consisting of five or more items had reliability>0.90, correlated ≥0.97 with the full scale, and had root mean square error <0.25. The average RVs for these CATs ranged 1.02-1.33, indicating possible savings in sample size requirements of 3-42% using CAT. Conclusion: The CAT versions of PF and FA exhibited high levels of measurement precision and efficiency. The potential savings in sample size requirements using CATs compared with those using the original QLQ-C30 scales were typically 20% or more.

Original language	English
Journal	Journal of Clinical Epidemiology
Volume	66
Issue number	3
Pages (from-to)	330-9
Number of pages	10
ISSN	0895-4356
DOIs	https://doi.org/10.1016/j.jclinepi.2012.09.010
Publication status	Published - Mar 2013

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CAT PF FA precision JCE 2013Submitted manuscript, 275 KB

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Petersen, M. A., Aaronson, N. K., Arraras, J. I., Chie, W-C., Conroy, T., Costantini, A., Giesinger, J. M., Holzner, B., King, M. T., Singer, S., Velikova, G., Verdonck-de Leeuw, I. M., Young, T., Grønvold, M., & EORTC Quality of Life Group (2013). The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency. Journal of Clinical Epidemiology, 66(3), 330-9. https://doi.org/10.1016/j.jclinepi.2012.09.010

Petersen, MA, Aaronson, NK, Arraras, JI, Chie, W-C, Conroy, T, Costantini, A, Giesinger, JM, Holzner, B, King, MT, Singer, S, Velikova, G, Verdonck-de Leeuw, IM, Young, T, Grønvold, M & EORTC Quality of Life Group 2013, 'The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency', Journal of Clinical Epidemiology, vol. 66, no. 3, pp. 330-9. https://doi.org/10.1016/j.jclinepi.2012.09.010

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abstract = "Objectives: The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group is developing a computer-adaptive test (CAT) version of the EORTC Quality of Life Questionnaire (QLQ-C30). We evaluated the measurement properties of the CAT versions of physical functioning (PF) and fatigue (FA) and compared these with the corresponding QLQ-C30 scales. Study Design and Setting: Based on international samples of more than 1,000 cancer patients, we simulated CAT administration of varying numbers of items and compared the resulting scores with those based on all items in the respective item pools. Furthermore, the relative validity (RV) of CATs was compared with that of the QLQ-C30 scales using known groups validity. Results: For both dimensions, CATs of all lengths resulted in unbiased score estimates. CATs consisting of five or more items had reliability>0.90, correlated ≥0.97 with the full scale, and had root mean square error <0.25. The average RVs for these CATs ranged 1.02-1.33, indicating possible savings in sample size requirements of 3-42% using CAT. Conclusion: The CAT versions of PF and FA exhibited high levels of measurement precision and efficiency. The potential savings in sample size requirements using CATs compared with those using the original QLQ-C30 scales were typically 20% or more.",

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AU - Chie, Wei-Chu

AU - Conroy, Thierry

AU - Costantini, Anna

AU - Giesinger, Johannes M

AU - Holzner, Bernhard

AU - King, Madeleine T

AU - Singer, Susanne

AU - Velikova, Galina

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AU - Grønvold, Mogens

AU - EORTC Quality of Life Group

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The EORTC computer-adaptive tests measuring physical functioning and fatigue exhibited high levels of measurement precision and efficiency

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