The E2F family: specific functions and overlapping interests.

TY - JOUR

T1 - The E2F family: specific functions and overlapping interests.

AU - Attwooll, Claire

AU - Lazzerini Denchi, Eros

AU - Helin, Kristian

N1 - Keywords: Animals; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; DNA-Binding Proteins; E2F Transcription Factors; Gene Expression Regulation; Phenotype; Protein Binding; Transcription Factors

PY - 2004

Y1 - 2004

N2 - The E2F transcription factors are key regulators of cell cycle progression and the E2F field has made rapid advances since its advent in 1986. Yet, while our understanding of the roles and functions of the E2F family has made enormous progress, with each discovery new questions arise. In this review, we summarise the most recent advances in the field and discuss the remaining key questions. In particular, we will focus on how specificity is achieved among the E2Fs.

AB - The E2F transcription factors are key regulators of cell cycle progression and the E2F field has made rapid advances since its advent in 1986. Yet, while our understanding of the roles and functions of the E2F family has made enormous progress, with each discovery new questions arise. In this review, we summarise the most recent advances in the field and discuss the remaining key questions. In particular, we will focus on how specificity is achieved among the E2Fs.

U2 - 10.1038/sj.emboj.7600481

DO - 10.1038/sj.emboj.7600481

M3 - Review

C2 - 15538380

SN - 0261-4189

VL - 23

SP - 4709

EP - 4716

JO - E M B O Journal

JF - E M B O Journal

IS - 24

ER -