The design and implementation of the immune epitope database and analysis resource

Bjoern Peters; John Sidney; Phil Bourne; Huynh-Hoa Bui; Soeren Buus; Grace Doh; Ward Fleri; Mitch Kronenberg; Ralph Kubo; Ole Lund; David Nemazee; Julia V Ponomarenko; Muthu Sathiamurthy; Stephen P Schoenberger; Scott Stewart; Pamela Surko; Scott Way; Steve Wilson; Alessandro Sette

doi:10.1007/s00251-005-0803-5

The design and implementation of the immune epitope database and analysis resource

Bjoern Peters, John Sidney, Phil Bourne, Huynh-Hoa Bui, Soeren Buus, Grace Doh, Ward Fleri, Mitch Kronenberg, Ralph Kubo, Ole Lund, David Nemazee, Julia V Ponomarenko, Muthu Sathiamurthy, Stephen P Schoenberger, Scott Stewart, Pamela Surko, Scott Way, Steve Wilson, Alessandro Sette

Department of Immunology and Microbiology

79 Citations (Scopus)

Abstract

Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, "The Immune Epitope Database and Analysis Resource." We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.

Original language	English
Journal	Immunogenetics
Volume	57
Issue number	5
Pages (from-to)	326-36
Number of pages	10
ISSN	0093-7711
DOIs	https://doi.org/10.1007/s00251-005-0803-5
Publication status	Published - 2005

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Peters, B., Sidney, J., Bourne, P., Bui, H-H., Buus, S., Doh, G., Fleri, W., Kronenberg, M., Kubo, R., Lund, O., Nemazee, D., Ponomarenko, J. V., Sathiamurthy, M., Schoenberger, S. P., Stewart, S., Surko, P., Way, S., Wilson, S., & Sette, A. (2005). The design and implementation of the immune epitope database and analysis resource. Immunogenetics, 57(5), 326-36. https://doi.org/10.1007/s00251-005-0803-5

Peters, B, Sidney, J, Bourne, P, Bui, H-H, Buus, S, Doh, G, Fleri, W, Kronenberg, M, Kubo, R, Lund, O, Nemazee, D, Ponomarenko, JV, Sathiamurthy, M, Schoenberger, SP, Stewart, S, Surko, P, Way, S, Wilson, S & Sette, A 2005, 'The design and implementation of the immune epitope database and analysis resource', Immunogenetics, vol. 57, no. 5, pp. 326-36. https://doi.org/10.1007/s00251-005-0803-5

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title = "The design and implementation of the immune epitope database and analysis resource",

abstract = "Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, {"}The Immune Epitope Database and Analysis Resource.{"} We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.",

author = "Bjoern Peters and John Sidney and Phil Bourne and Huynh-Hoa Bui and Soeren Buus and Grace Doh and Ward Fleri and Mitch Kronenberg and Ralph Kubo and Ole Lund and David Nemazee and Ponomarenko, {Julia V} and Muthu Sathiamurthy and Schoenberger, {Stephen P} and Scott Stewart and Pamela Surko and Scott Way and Steve Wilson and Alessandro Sette",

note = "Keywords: Animals; Databases, Factual; Epitopes; Humans; Immunodominant Epitopes; Internet; Protein Structure, Tertiary",

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doi = "10.1007/s00251-005-0803-5",

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AU - Peters, Bjoern

AU - Sidney, John

AU - Bourne, Phil

AU - Bui, Huynh-Hoa

AU - Buus, Soeren

AU - Doh, Grace

AU - Fleri, Ward

AU - Kronenberg, Mitch

AU - Kubo, Ralph

AU - Lund, Ole

AU - Nemazee, David

AU - Ponomarenko, Julia V

AU - Sathiamurthy, Muthu

AU - Schoenberger, Stephen P

AU - Stewart, Scott

AU - Surko, Pamela

AU - Way, Scott

AU - Wilson, Steve

AU - Sette, Alessandro

N1 - Keywords: Animals; Databases, Factual; Epitopes; Humans; Immunodominant Epitopes; Internet; Protein Structure, Tertiary

PY - 2005

Y1 - 2005

N2 - Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, "The Immune Epitope Database and Analysis Resource." We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.

AB - Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, "The Immune Epitope Database and Analysis Resource." We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.

U2 - 10.1007/s00251-005-0803-5

DO - 10.1007/s00251-005-0803-5

M3 - Journal article

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SN - 0093-7711

VL - 57

SP - 326

EP - 336

JO - Immunogenetics

JF - Immunogenetics

IS - 5

ER -

The design and implementation of the immune epitope database and analysis resource

Abstract

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