Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

R.M. Sharpe; Niels Erik Skakkebæk

Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

Department of Clinical Medicine

274 Citations (Scopus)

Abstract

Reproductive disorders of newborn (cryptorchidism, hypospadias) and young adult males (low sperm counts, testicular germ cell cancer) are common and/or increasing in incidence. It has been hypothesized that these disorders may comprise a testicular dysgenesis syndrome (TDS) with a common origin in fetal life. This has been supported by findings in an animal model of TDS involving fetal exposure to n(dibutyl) phthalate, as well as by new clinical studies. Recent advances in understanding from such studies have led to refinement of the TDS hypothesis, highlighting the central role that deficient androgen production/action during fetal testis development, may play in the origin of downstream disorders
Udgivelsesdato: 2008/2

Original language	English
Journal	Fertility and Sterility
Volume	89
Issue number	2 Suppl
Pages (from-to)	e33-e38
ISSN	0015-0282
Publication status	Published - 2008

Cite this

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abstract = "Reproductive disorders of newborn (cryptorchidism, hypospadias) and young adult males (low sperm counts, testicular germ cell cancer) are common and/or increasing in incidence. It has been hypothesized that these disorders may comprise a testicular dysgenesis syndrome (TDS) with a common origin in fetal life. This has been supported by findings in an animal model of TDS involving fetal exposure to n(dibutyl) phthalate, as well as by new clinical studies. Recent advances in understanding from such studies have led to refinement of the TDS hypothesis, highlighting the central role that deficient androgen production/action during fetal testis development, may play in the origin of downstream disorders Udgivelsesdato: 2008/2",

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AB - Reproductive disorders of newborn (cryptorchidism, hypospadias) and young adult males (low sperm counts, testicular germ cell cancer) are common and/or increasing in incidence. It has been hypothesized that these disorders may comprise a testicular dysgenesis syndrome (TDS) with a common origin in fetal life. This has been supported by findings in an animal model of TDS involving fetal exposure to n(dibutyl) phthalate, as well as by new clinical studies. Recent advances in understanding from such studies have led to refinement of the TDS hypothesis, highlighting the central role that deficient androgen production/action during fetal testis development, may play in the origin of downstream disorders Udgivelsesdato: 2008/2

M3 - Journal article

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VL - 89

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JO - Sexuality, Reproduction and Menopause

JF - Sexuality, Reproduction and Menopause

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