Ten-year mortality is increased after hospitalization for atopic dermatitis compared with the general population, but reduced compared with psoriasis

TY - JOUR

T1 - Ten-year mortality is increased after hospitalization for atopic dermatitis compared with the general population, but reduced compared with psoriasis

AU - Egeberg, Alexander

AU - Skov, Lone

AU - Andersen, Yuki M F

AU - Mallbris, Lotus

AU - Gislason, Gunnar H.

AU - Silverberg, Jonathan I

AU - Wu, Jashin J

AU - Thyssen, Jacob P.

PY - 2017

Y1 - 2017

N2 - Background Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin disorders. Mortality is increased in psoriasis, yet no studies on mortality in AD are currently available. Objective We investigated 10-year mortality after hospitalization for AD compared with psoriasis and the general population. Methods Between 1996 and 2002 all Danes aged 18 years or older with a first-time hospitalization as a result of AD or psoriasis and AD-matched healthy control subjects were examined in nationwide registers. Multivariable (adjusted for age, sex, socioeconomic status, Charlson Comorbidity Index score, smoking, and medication) hazard ratios were estimated by Cox regression. Results The study comprised 576 and 951 hospitalized patients with AD and psoriasis, respectively, with a maximum follow-up time of 10 years. During the study period, there were 65 and 286 deaths among patients with AD and psoriasis. Risk of death was decreased in patients with AD versus psoriasis (hazard ratio 0.75; 95% confidence interval 0.57-1.00), but higher than in general population control subjects (n = 5760) (hazard ratio 1.71; 95% confidence interval 1.20-2.44). Patients hospitalized with AD died on average 8.3 years younger than control subjects. Limitations Lifestyle may have affected the risk. Conclusions The 10-year mortality was significantly lower after hospitalization for AD compared with psoriasis, but increased when compared with the general population.

AB - Background Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin disorders. Mortality is increased in psoriasis, yet no studies on mortality in AD are currently available. Objective We investigated 10-year mortality after hospitalization for AD compared with psoriasis and the general population. Methods Between 1996 and 2002 all Danes aged 18 years or older with a first-time hospitalization as a result of AD or psoriasis and AD-matched healthy control subjects were examined in nationwide registers. Multivariable (adjusted for age, sex, socioeconomic status, Charlson Comorbidity Index score, smoking, and medication) hazard ratios were estimated by Cox regression. Results The study comprised 576 and 951 hospitalized patients with AD and psoriasis, respectively, with a maximum follow-up time of 10 years. During the study period, there were 65 and 286 deaths among patients with AD and psoriasis. Risk of death was decreased in patients with AD versus psoriasis (hazard ratio 0.75; 95% confidence interval 0.57-1.00), but higher than in general population control subjects (n = 5760) (hazard ratio 1.71; 95% confidence interval 1.20-2.44). Patients hospitalized with AD died on average 8.3 years younger than control subjects. Limitations Lifestyle may have affected the risk. Conclusions The 10-year mortality was significantly lower after hospitalization for AD compared with psoriasis, but increased when compared with the general population.

KW - atopic dermatitis

KW - epidemiology

KW - inflammation

KW - mortality

KW - psoriasis

U2 - 10.1016/j.jaad.2016.06.021

DO - 10.1016/j.jaad.2016.06.021

M3 - Journal article

C2 - 27742169

AN - SCOPUS:85002044981

SN - 0190-9622

VL - 76

SP - 98

EP - 105

JO - American Academy of Dermatology. Journal

JF - American Academy of Dermatology. Journal

IS - 1

ER -