Abstract
miRNAs (microRNAs) comprise a class of small endogenous non-coding RNAs that post-transcriptionally repress gene expression by base-pairing with their target mRNAs. Recent evidence has shown that miRNAs play important roles in a wide variety of human diseases, such as viral infections, cancer and cardiovascular diseases, and thus miRNAs have rapidly emerged as potential targets for therapeutics. LNAs (locked nucleic acids) comprise a class of bicyclic conformational analogues of RNA, which exhibit high binding affinity to complementary RNA molecules and high stability in blood and tissues in vivo. Recent reports on LNA-mediated miRNA silencing in rodents and primates support the potential of LNA-modified oligonucleotides in studying miRNA functions in vivo and in the future development of miRNA-based therapeutics.
| Original language | English |
|---|---|
| Journal | Biochemical Society Transactions |
| Volume | 36 |
| Issue number | Pt 6 |
| Pages (from-to) | 1197-200 |
| Number of pages | 3 |
| ISSN | 0300-5127 |
| DOIs | |
| Publication status | Published - 2008 |
