Abstract
Until recently there existed no appropriate immunological animal models for human inflammatory bowel diseases (IBD). Today a number of models, mostly in the mouse and rat, have proved useful in the study of several aspects of IBD, including the histopathology and the disease-inductive and -protective cell types, subsets and cytokines, for example CD4+ T cells, IFN gamma, IL-12, IL-2, IL-10 and TGF beta. Furthermore, these recent IBD models make it possible to examine various chemo- and immunotherapeutic approaches. This review focuses on IBD development in adoptive T-cell transfer models and in gene-deleted mice.
| Original language | English |
|---|---|
| Journal | Acta Pathologica Microbiologica et Immunologica Scandinavica |
| Volume | 105 |
| Issue number | 9 |
| Pages (from-to) | 655-662 |
| Number of pages | 8 |
| ISSN | 0903-4641 |
| Publication status | Published - 1997 |
Keywords
- Animals
- B-Lymphocytes
- CD4-Positive T-Lymphocytes
- Cytokines
- Disease Models, Animal
- GTP-Binding Protein alpha Subunits, Gi-Go
- Gene Deletion
- Genes, T-Cell Receptor
- Immunity, Mucosal
- Immunization, Passive
- Inflammatory Bowel Diseases
- Interleukin-10
- Mice
- Mice, Knockout
- Mice, SCID
- Rats
- T-Lymphocytes
