@inbook{478d24cfba4a43508ad318dcfd6d9aea,
title = "Synthesis of N-methylated peptides: on-resin methylation and microwave-assisted couplings",
abstract = "N-Methylation may positively influence the pharmacokinetic properties of peptides by improving oral availability and in vivo half-life. Additionally, target affinity and specificity may be improved. Here, we describe the solid-phase N-methylation of peptides using direct alkylation. This method allows a rapid N-methyl scan of synthetic, bioactive peptides. Additionally, a microwave-enhanced method for the difficult coupling onto the methylated N terminus is provided.",
keywords = "Backbone amide linker, Handle, Peptide, Aldehyde, Thioester, N-Alkyl amide, Cyclic peptide, Reductive amination",
author = "Ren{\'e}e Roodbeen and Jensen, {Knud J{\o}rgen}",
year = "2013",
doi = "10.1007/978-1-62703-544-6_10",
language = "English",
isbn = "978-1-62703-543-9",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "141--149",
editor = "Jensen, {Knud J.} and Shelton, {Pernille T.} and Pedersen, {S{\o}ren L.}",
booktitle = "Peptide synthesis and applications",
address = "United States",
}