Suicide and mental illness in parents and risk of suicide in offspring: a birth cohort study

TY - JOUR

T1 - Suicide and mental illness in parents and risk of suicide in offspring: a birth cohort study

AU - Sørensen, Holger J

AU - Mortensen, Erik L

AU - Wang, August G

AU - Juel, Knud

AU - Silverton, Leigh

AU - Mednick, Sarnoff A

N1 - Keywords: Adult; Adult Children; Cause of Death; Child; Child of Impaired Parents; Cohort Studies; Denmark; Fathers; Female; Hospitalization; Hospitals, Psychiatric; Humans; Male; Mental Disorders; Mothers; Registries; Risk Factors; Sex Factors; Suicide

PY - 2009

Y1 - 2009

N2 - BACKGROUND: A family history of completed suicide and psychiatric illness has been identified as risk factors for suicide. AIMS: To examine the risk of offspring suicide in relation to parental history of suicide and other parental risk factors. METHOD: The study population consisted of 7,177 adult offspring born 1959-1961 and their parents from the Copenhagen Perinatal Cohort. Cohort members and their parents who had committed suicide were identified in the Danish Causes of Death Registry (follow-up until December 31, 2005), while information on psychiatric hospitalisation history was obtained from the Danish Psychiatric Central Research Register. RESULTS: Forty-eight cohort members, 77 mothers and 133 fathers had committed suicide during the follow-up. Independent of parental psychiatric illness and social status, parental suicide significantly increased suicide risk in offspring (hazard ratio 4.40 with 95% CI 1.81-10.69). A stronger effect of parental suicide was observed in offspring without a history of psychiatric hospitalisation. CONCLUSION: Parental history of suicide is a risk factor for suicide in offspring, but primarily in offspring without psychiatric hospitalisation.

AB - BACKGROUND: A family history of completed suicide and psychiatric illness has been identified as risk factors for suicide. AIMS: To examine the risk of offspring suicide in relation to parental history of suicide and other parental risk factors. METHOD: The study population consisted of 7,177 adult offspring born 1959-1961 and their parents from the Copenhagen Perinatal Cohort. Cohort members and their parents who had committed suicide were identified in the Danish Causes of Death Registry (follow-up until December 31, 2005), while information on psychiatric hospitalisation history was obtained from the Danish Psychiatric Central Research Register. RESULTS: Forty-eight cohort members, 77 mothers and 133 fathers had committed suicide during the follow-up. Independent of parental psychiatric illness and social status, parental suicide significantly increased suicide risk in offspring (hazard ratio 4.40 with 95% CI 1.81-10.69). A stronger effect of parental suicide was observed in offspring without a history of psychiatric hospitalisation. CONCLUSION: Parental history of suicide is a risk factor for suicide in offspring, but primarily in offspring without psychiatric hospitalisation.

U2 - http://dx.doi.org/10.1007/s00127-009-0495-5

DO - http://dx.doi.org/10.1007/s00127-009-0495-5

M3 - Journal article

SN - 0933-7954

VL - 44

SP - 748

EP - 751

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

IS - 9

ER -