Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man.

J B Krøll; J Nøhr; N Gregersen; K Kristiansen; S Mandrup

doi:10.1016/0378-1119(96)00214-4

Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man.

J B Krøll, J Nøhr, N Gregersen, K Kristiansen, S Mandrup

4 Citations (Scopus)

Abstract

The entire gene encoding the rat acyl-CoA-binding protein (ACBP), and intron 1 of the mouse and human ACBP genes were sequenced and analyzed. A CpG island has been maintained in human ACBP which, in contrast to the rodent ACBP genes, is subject to alternative splicing. Analysis of the rat intron 2 and 3 sequences identified a number of potential alternative splice donor and splice acceptor sites. However, RNase protection analysis revealed no alternatively spliced transcripts in RNA from various rat tissues. Several repetitive elements belonging to the ID, B1 and B2 families are present in introns 2 and 3.

Original language	English
Journal	Gene
Volume	173
Issue number	2
Pages (from-to)	239-40
Number of pages	1
ISSN	0378-1119
DOIs	https://doi.org/10.1016/0378-1119(96)00214-4
Publication status	Published - 1996
Externally published	Yes

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10.1016/0378-1119(96)00214-4

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@article{b98dfdf00fa311de8478000ea68e967b,

title = "Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man.",

abstract = "The entire gene encoding the rat acyl-CoA-binding protein (ACBP), and intron 1 of the mouse and human ACBP genes were sequenced and analyzed. A CpG island has been maintained in human ACBP which, in contrast to the rodent ACBP genes, is subject to alternative splicing. Analysis of the rat intron 2 and 3 sequences identified a number of potential alternative splice donor and splice acceptor sites. However, RNase protection analysis revealed no alternatively spliced transcripts in RNA from various rat tissues. Several repetitive elements belonging to the ID, B1 and B2 families are present in introns 2 and 3.",

author = "Kr{\o}ll, {J B} and J N{\o}hr and N Gregersen and K Kristiansen and S Mandrup",

note = "Keywords: Alternative Splicing; Animals; Carrier Proteins; Conserved Sequence; CpG Islands; Diazepam Binding Inhibitor; Humans; Introns; Mice; Molecular Sequence Data; Rats; Repetitive Sequences, Nucleic Acid; Rodentia",

year = "1996",

doi = "10.1016/0378-1119(96)00214-4",

language = "English",

volume = "173",

pages = "239--40",

journal = "Gene",

issn = "0378-1119",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man.

AU - Krøll, J B

AU - Nøhr, J

AU - Gregersen, N

AU - Kristiansen, K

AU - Mandrup, S

N1 - Keywords: Alternative Splicing; Animals; Carrier Proteins; Conserved Sequence; CpG Islands; Diazepam Binding Inhibitor; Humans; Introns; Mice; Molecular Sequence Data; Rats; Repetitive Sequences, Nucleic Acid; Rodentia

PY - 1996

Y1 - 1996

N2 - The entire gene encoding the rat acyl-CoA-binding protein (ACBP), and intron 1 of the mouse and human ACBP genes were sequenced and analyzed. A CpG island has been maintained in human ACBP which, in contrast to the rodent ACBP genes, is subject to alternative splicing. Analysis of the rat intron 2 and 3 sequences identified a number of potential alternative splice donor and splice acceptor sites. However, RNase protection analysis revealed no alternatively spliced transcripts in RNA from various rat tissues. Several repetitive elements belonging to the ID, B1 and B2 families are present in introns 2 and 3.

AB - The entire gene encoding the rat acyl-CoA-binding protein (ACBP), and intron 1 of the mouse and human ACBP genes were sequenced and analyzed. A CpG island has been maintained in human ACBP which, in contrast to the rodent ACBP genes, is subject to alternative splicing. Analysis of the rat intron 2 and 3 sequences identified a number of potential alternative splice donor and splice acceptor sites. However, RNase protection analysis revealed no alternatively spliced transcripts in RNA from various rat tissues. Several repetitive elements belonging to the ID, B1 and B2 families are present in introns 2 and 3.

U2 - 10.1016/0378-1119(96)00214-4

DO - 10.1016/0378-1119(96)00214-4

M3 - Journal article

C2 - 8964506

SN - 0378-1119

VL - 173

SP - 239

EP - 240

JO - Gene

JF - Gene

IS - 2

ER -

Structure of the rat gene encoding the multifunctional acyl-CoA-binding protein: conservation of intron 1 sequences in rodents and man.

Abstract

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