Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

TY - JOUR

T1 - Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

AU - Sette, A

AU - Buus, S

AU - Colon, S

AU - Smith, J A

AU - Miles, C

AU - Grey, H M

N1 - Keywords: Amino Acid Sequence; Animals; Antigens; Binding, Competitive; Histocompatibility Antigens Class II; Hybridomas; Ovalbumin; Peptide Fragments; Peptides; Structure-Activity Relationship; T-Lymphocytes

PY - 1987

Y1 - 1987

N2 - A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.

AB - A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.

U2 - 10.1038/328395a0

DO - 10.1038/328395a0

M3 - Journal article

C2 - 3497349

SN - 0028-0836

VL - 328

SP - 395

EP - 399

JO - Nature

JF - Nature

IS - 6129

ER -