Smoking and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults

Janne S Tolstrup; Ulla Arthur Hvidtfeldt; Esben Meulengracht Flachs; Donna Spiegelman; Berit L Heitmann; Katarina Bälter; Uri Goldbourt; Göran Hallmans; Paul Knekt; Simin Liu; Mark Pereira; June Stevens; Jarmo Virtamo; Diane Feskanich

doi:10.2105/AJPH.2012.301091

Smoking and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults

Janne S Tolstrup, Ulla Arthur Hvidtfeldt, Esben Meulengracht Flachs, Donna Spiegelman, Berit L Heitmann, Katarina Bälter, Uri Goldbourt, Göran Hallmans, Paul Knekt, Simin Liu, Mark Pereira, June Stevens, Jarmo Virtamo, Diane Feskanich

Section of Social Medicine

36 Citations (Scopus)

Abstract

Objectives: We investigated associations of smoking and coronary heart disease (CHD) by age. Methods: Data came from the Pooling Project on Diet and Coronary Heart Disease (8 prospective studies, 1974-1996; n = 192 067 women and 74 720 men, aged 40-89 years). Results: During follow-up, 4326 cases of CHD were reported. Relative to never smokers, CHD risk among current smokers was highest in the youngest and lowest in the oldest participants. For example, among women aged 40 to 49 years the hazard ratio was 8.5 (95% confidence interval [CI]= 5.0, 14) and 3.1 (95% CI = 2.0, 4.9) among those aged 70 years or older. The largest absolute risk differences between current smokers and never smokers were observed among the oldest participants. Finally, the majority of CHD cases among smokers were attributable to smoking. For example, attributable proportions of CHD by age group were 88% (40-49 years), 81% (50-59 years), 71% for (60-69 years), and 68% (≥70 years) among women who smoked. Conclusions: Among smokers, the majority of CHD cases are attributable to smoking in all age groups. Smoking prevention is important, irrespective of age.

Original language	English
Journal	American Journal of Public Health
Volume	104
Issue number	1
Pages (from-to)	96-102
Number of pages	7
ISSN	0090-0036
DOIs	https://doi.org/10.2105/AJPH.2012.301091
Publication status	Published - Jan 2014

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Tolstrup, J. S., Hvidtfeldt, U. A., Flachs, E. M., Spiegelman, D., Heitmann, B. L., Bälter, K., Goldbourt, U., Hallmans, G., Knekt, P., Liu, S., Pereira, M., Stevens, J., Virtamo, J., & Feskanich, D. (2014). Smoking and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults. American Journal of Public Health, 104(1), 96-102. https://doi.org/10.2105/AJPH.2012.301091

Tolstrup, JS, Hvidtfeldt, UA, Flachs, EM, Spiegelman, D, Heitmann, BL, Bälter, K, Goldbourt, U, Hallmans, G, Knekt, P, Liu, S, Pereira, M, Stevens, J, Virtamo, J & Feskanich, D 2014, 'Smoking and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults', American Journal of Public Health, vol. 104, no. 1, pp. 96-102. https://doi.org/10.2105/AJPH.2012.301091

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title = "Smoking and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults",

abstract = "Objectives: We investigated associations of smoking and coronary heart disease (CHD) by age. Methods: Data came from the Pooling Project on Diet and Coronary Heart Disease (8 prospective studies, 1974-1996; n = 192 067 women and 74 720 men, aged 40-89 years). Results: During follow-up, 4326 cases of CHD were reported. Relative to never smokers, CHD risk among current smokers was highest in the youngest and lowest in the oldest participants. For example, among women aged 40 to 49 years the hazard ratio was 8.5 (95% confidence interval [CI]= 5.0, 14) and 3.1 (95% CI = 2.0, 4.9) among those aged 70 years or older. The largest absolute risk differences between current smokers and never smokers were observed among the oldest participants. Finally, the majority of CHD cases among smokers were attributable to smoking. For example, attributable proportions of CHD by age group were 88% (40-49 years), 81% (50-59 years), 71% for (60-69 years), and 68% (≥70 years) among women who smoked. Conclusions: Among smokers, the majority of CHD cases are attributable to smoking in all age groups. Smoking prevention is important, irrespective of age.",

author = "Tolstrup, {Janne S} and Hvidtfeldt, {Ulla Arthur} and Flachs, {Esben Meulengracht} and Donna Spiegelman and Heitmann, {Berit L} and Katarina B{\"a}lter and Uri Goldbourt and G{\"o}ran Hallmans and Paul Knekt and Simin Liu and Mark Pereira and June Stevens and Jarmo Virtamo and Diane Feskanich",

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AU - Tolstrup, Janne S

AU - Hvidtfeldt, Ulla Arthur

AU - Flachs, Esben Meulengracht

AU - Spiegelman, Donna

AU - Heitmann, Berit L

AU - Bälter, Katarina

AU - Goldbourt, Uri

AU - Hallmans, Göran

AU - Knekt, Paul

AU - Liu, Simin

AU - Pereira, Mark

AU - Stevens, June

AU - Virtamo, Jarmo

AU - Feskanich, Diane

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N2 - Objectives: We investigated associations of smoking and coronary heart disease (CHD) by age. Methods: Data came from the Pooling Project on Diet and Coronary Heart Disease (8 prospective studies, 1974-1996; n = 192 067 women and 74 720 men, aged 40-89 years). Results: During follow-up, 4326 cases of CHD were reported. Relative to never smokers, CHD risk among current smokers was highest in the youngest and lowest in the oldest participants. For example, among women aged 40 to 49 years the hazard ratio was 8.5 (95% confidence interval [CI]= 5.0, 14) and 3.1 (95% CI = 2.0, 4.9) among those aged 70 years or older. The largest absolute risk differences between current smokers and never smokers were observed among the oldest participants. Finally, the majority of CHD cases among smokers were attributable to smoking. For example, attributable proportions of CHD by age group were 88% (40-49 years), 81% (50-59 years), 71% for (60-69 years), and 68% (≥70 years) among women who smoked. Conclusions: Among smokers, the majority of CHD cases are attributable to smoking in all age groups. Smoking prevention is important, irrespective of age.

AB - Objectives: We investigated associations of smoking and coronary heart disease (CHD) by age. Methods: Data came from the Pooling Project on Diet and Coronary Heart Disease (8 prospective studies, 1974-1996; n = 192 067 women and 74 720 men, aged 40-89 years). Results: During follow-up, 4326 cases of CHD were reported. Relative to never smokers, CHD risk among current smokers was highest in the youngest and lowest in the oldest participants. For example, among women aged 40 to 49 years the hazard ratio was 8.5 (95% confidence interval [CI]= 5.0, 14) and 3.1 (95% CI = 2.0, 4.9) among those aged 70 years or older. The largest absolute risk differences between current smokers and never smokers were observed among the oldest participants. Finally, the majority of CHD cases among smokers were attributable to smoking. For example, attributable proportions of CHD by age group were 88% (40-49 years), 81% (50-59 years), 71% for (60-69 years), and 68% (≥70 years) among women who smoked. Conclusions: Among smokers, the majority of CHD cases are attributable to smoking in all age groups. Smoking prevention is important, irrespective of age.

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DO - 10.2105/AJPH.2012.301091

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JO - American Journal of Public Health

JF - American Journal of Public Health

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ER -

Smoking and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults

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