Serum YKL-40 and uterine artery Doppler – a prospective cohort study, with focus on preeclampsia and small-for-gestational-age

TY - JOUR

T1 - Serum YKL-40 and uterine artery Doppler – a prospective cohort study, with focus on preeclampsia and small-for-gestational-age

AU - Gybel-Brask, Dorte

AU - Høgdall, Estrid

AU - Johansen, Julia

AU - Christensen, Ib Jarle

AU - Skibsted, Lillian

N1 - © 2014 Nordic Federation of Societies of Obstetrics and Gynecology.

PY - 2014/8

Y1 - 2014/8

N2 - Objective To test if serum YKL-40 is increased in women developing preeclampsia or small-for-gestational age fetuses. We also assessed the association between uterine artery pulsatility index, notching and serum YKL-40 levels. Design Prospective cohort study. Setting A primary referral unit for obstetric ultrasound. Population A total of 1214 unselected pregnant women enrolled at nuchal translucency examination between 11+3 and 13 +6 weeks of gestation. Methods All women had ultrasound and blood sample collection at the nuchal translucency scan, a 20-week malformation scan and 25-week and 32-week fetal growth examinations. Uterine artery Doppler was assessed and outcome was registered from medical records. Main outcome measures Preeclampsia, hypertension, small-for-gestational age. Results Serum YKL-40 was associated with increasing maternal age (p < 0.0001), body mass index (p = 0.0002), primiparity (p = 0.0003), and hypertension (p = 0.015). Serum YKL-40 increased from 12 to 20 weeks and decreased from 20-25 and 25-32 weeks of gestation. No association was found between preeclampsia and serum YKL-40. Small-for-gestational-age at birth was significantly associated with a 5.4% increase in serum YKL-40 at 32 weeks of gestation (95% CI 1.5-9.3, p = 0.005). An association was found between uterine artery pulsatility index at 32 weeks and small-for-gestational age (p = 0.0015) but not between YKL-40 and uterine artery notching (p = 0.83). Conclusions Serum YKL-40 was not associated with preeclampsia. Increasing serum YKL-40 was related to maternal age, body mass index and small-for-gestational age and may reflect an exaggerated inflammatory response.

AB - Objective To test if serum YKL-40 is increased in women developing preeclampsia or small-for-gestational age fetuses. We also assessed the association between uterine artery pulsatility index, notching and serum YKL-40 levels. Design Prospective cohort study. Setting A primary referral unit for obstetric ultrasound. Population A total of 1214 unselected pregnant women enrolled at nuchal translucency examination between 11+3 and 13 +6 weeks of gestation. Methods All women had ultrasound and blood sample collection at the nuchal translucency scan, a 20-week malformation scan and 25-week and 32-week fetal growth examinations. Uterine artery Doppler was assessed and outcome was registered from medical records. Main outcome measures Preeclampsia, hypertension, small-for-gestational age. Results Serum YKL-40 was associated with increasing maternal age (p < 0.0001), body mass index (p = 0.0002), primiparity (p = 0.0003), and hypertension (p = 0.015). Serum YKL-40 increased from 12 to 20 weeks and decreased from 20-25 and 25-32 weeks of gestation. No association was found between preeclampsia and serum YKL-40. Small-for-gestational-age at birth was significantly associated with a 5.4% increase in serum YKL-40 at 32 weeks of gestation (95% CI 1.5-9.3, p = 0.005). An association was found between uterine artery pulsatility index at 32 weeks and small-for-gestational age (p = 0.0015) but not between YKL-40 and uterine artery notching (p = 0.83). Conclusions Serum YKL-40 was not associated with preeclampsia. Increasing serum YKL-40 was related to maternal age, body mass index and small-for-gestational age and may reflect an exaggerated inflammatory response.

KW - Adipokines

KW - Adolescent

KW - Adult

KW - Biological Markers

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Fetal Growth Retardation

KW - Humans

KW - Infant, Newborn

KW - Infant, Small for Gestational Age

KW - Lectins

KW - Linear Models

KW - Logistic Models

KW - Pre-Eclampsia

KW - Pregnancy

KW - Prospective Studies

KW - Pulsatile Flow

KW - Ultrasonography, Doppler, Color

KW - Ultrasonography, Prenatal

KW - Uterine Artery

KW - Young Adult

U2 - 10.1111/aogs.12432

DO - 10.1111/aogs.12432

M3 - Journal article

C2 - 24861484

SN - 0001-6349

VL - 93

SP - 817

EP - 824

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 8

ER -