Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus

TY - JOUR

T1 - Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus

AU - Andersen, T.

AU - Munthe-Fog, L.

AU - Garred, P.

AU - Jacobsen, Søren

AU - Andersen, Trine

AU - Munthe-Fog, Lea

AU - Garred, Peter

AU - Jacobsen, Søren

N1 - Keywords: Adolescent; Adult; Aged; Child; Female; Glycoproteins; Humans; Lectins; Lupus Erythematosus, Systemic; Male; Middle Aged; Severity of Illness Index; Young Adult

PY - 2009/4/1

Y1 - 2009/4/1

N2 - OBJECTIVE: Ficolin-3 is a serum protein of putative importance in autoimmunity. Our objective was to investigate any differential expression of ficolin-3 in patients with systemic lupus erythematosus (SLE) or its clinical subsets. METHODS: Serum levels of ficolin-3 (S-ficolin-3) were determined in 95 patients with SLE and 103 healthy controls using an ELISA. RESULTS: Median S-ficolin-3 was 56.1 microg/ml (range 0 to >or=87.3) and 32.4 microg/ml (10 to >or=87.3) in patients and controls, respectively (p<0.001). Increased S-ficolin-3 was associated with hemolysis, positive Coombs test, and lymphopenia, but not with SLE Disease Activity Index scores or C-reactive protein. In one patient without detectable S-ficolin-3, the FCN3 gene appeared normal. CONCLUSION: The elevation of S-ficolin-3 and its association with specific manifestations in SLE may indicate a pathogenetic role of ficolin-3 in SLE.

AB - OBJECTIVE: Ficolin-3 is a serum protein of putative importance in autoimmunity. Our objective was to investigate any differential expression of ficolin-3 in patients with systemic lupus erythematosus (SLE) or its clinical subsets. METHODS: Serum levels of ficolin-3 (S-ficolin-3) were determined in 95 patients with SLE and 103 healthy controls using an ELISA. RESULTS: Median S-ficolin-3 was 56.1 microg/ml (range 0 to >or=87.3) and 32.4 microg/ml (10 to >or=87.3) in patients and controls, respectively (p<0.001). Increased S-ficolin-3 was associated with hemolysis, positive Coombs test, and lymphopenia, but not with SLE Disease Activity Index scores or C-reactive protein. In one patient without detectable S-ficolin-3, the FCN3 gene appeared normal. CONCLUSION: The elevation of S-ficolin-3 and its association with specific manifestations in SLE may indicate a pathogenetic role of ficolin-3 in SLE.

U2 - 10.3899/jrheum.080361

DO - 10.3899/jrheum.080361

M3 - Journal article

C2 - 19208603

SN - 0315-162X

VL - 36

SP - 757

EP - 759

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 4

ER -