Abstract
The incretin hormones gastric inhibitory polypeptide and especially glucagon-like peptide (GLP) have an important physiological function in augmenting postprandial insulin secretion. Since GLP-1 may play a role in the pathophysiology and treatment of type 2 diabetes, assessment of meal-related GLP-1 secretory responses in type 2 diabetic patients vs healthy individuals is of great interest. A common view states that GLP-1 secretion in patients with type 2 diabetes is deficient and that this applies to a lesser degree in individuals with impaired glucose tolerance. Such a deficiency is the rationale for replacing endogenous incretins with GLP-1 receptor agonists or re-normalising active GLP-1 concentrations with dipeptidyl peptidase-4 inhibitors. This review summarises the literature on this topic, including a meta-analysis of published studies on GLP-1 secretion in individuals with and without diabetes after oral glucose and mixed meals. Our analysis does not support the contention of a generalised defect in nutrient-related GLP-1 secretory responses in type 2 diabetes patients. Rather, factors are identified that may determine individual incretin secretory responses and explain some of the variations in published findings of group differences in GLP-1 responses to nutrient intake.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 54 |
| Issue number | 1 |
| Pages (from-to) | 10-18 |
| Number of pages | 9 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - Jan 2011 |
Keywords
- Animals
- Diabetes Mellitus, Type 2
- Glucagon-Like Peptide 1
- Humans
- Incretins
- Meta-Analysis as Topic
- Models, Biological
