Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk"

P.M. Ridker; J.G. MacFadyen; Børge G Nordestgaard; W. Koenig; J.J.P. Kastelein; J. Genest; R.J. Glynn; Paul M Ridker; Jean G Macfadyen; Wolfgang Koenig; John J P Kastelein; Jacques Genest; Robert J Glynn

doi:http://dx.doi.org/10.1161/CIRCOUTCOMES.110.938118

Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk"

P.M. Ridker, J.G. MacFadyen, Børge G Nordestgaard, W. Koenig, J.J.P. Kastelein, J. Genest, R.J. Glynn, Paul M Ridker, Jean G Macfadyen, Wolfgang Koenig, John J P Kastelein, Jacques Genest, Robert J Glynn

53 Citations (Scopus)

Abstract

Background: Recent primary prevention guidelines issued in Canada endorse the use of statin therapy among individuals at "intermediate risk" who have elevated levels of high-sensitivity C-reactive protein (hsCRP). However, trial data directly addressing whether this recommendation defines a patient population in which statin therapy is effective have not previously been published. Methods and Results: In the Justification for Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial, which demonstrated a 44% reduction in first vascular events when rosuvastatin 20 mg was compared with placebo among 17 802 primary prevention patients with LDL cholesterol <130 mg/dL and hsCRP ≥2 mg/L, 6091 participants (2525 women, 3566 men) had baseline estimated 10-year Framingham risks of 5% to 10% and 7340 participants (1404 women, 5936 men) had baseline estimated Framingham risk of 11% to 20%. In these 2 "intermediate risk" subgroups, relative risk reductions consistent with the overall trial treatment effect were observed (hazard ratio, 0.55; 95% confidence interval, 0.36 to 0.84; 5-year number needed to treat=40, P=0.005 for those with 5% to 10% risk; hazard ratio, 0.51; 95% confidence interval, 0.39 to 0.68, 5-year number needed to treat=18, P<0.0001 for those with 11% to 20% risk). Use of the Reynolds Risk Score to stratify the study population gave similar results but reclassified large numbers of individuals into lower-or higher-risk groups. The majority of women with elevated hsCRP who benefited from rosuvastatin were at 5% to 10% 10-year risk at study entry using either global risk scoring system. Conclusions: Consistent with recent evidence-based Canadian Cardiovascular Society guidelines for primary prevention, the JUPITER trial demonstrates that rosuvastatin 20 mg significantly reduces major cardiovascular events among men and women with elevated hsCRP and "intermediate risk" defined either as 5% to 10% or 10% to 20% 10-year risk. Clinical Trial Registration: URL: http:// clinicaltrials.gov. Unique identifier: NCT00239681.

Original language	English
Journal	Circulation. Cardiovascular Quality and Outcomes
Volume	3
Issue number	5
Pages (from-to)	447-52
Number of pages	6
DOIs	https://doi.org/10.1161/CIRCOUTCOMES.110.938118
Publication status	Published - Sept 2010

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Ridker, P. M., MacFadyen, J. G., Nordestgaard, B. G., Koenig, W., Kastelein, J. J. P., Genest, J., Glynn, R. J., Ridker, P. M., Macfadyen, J. G., Koenig, W., Kastelein, J. J. P., Genest, J., & Glynn, R. J. (2010). Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk". Circulation. Cardiovascular Quality and Outcomes, 3(5), 447-52. https://doi.org/10.1161/CIRCOUTCOMES.110.938118

Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention : an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk". / Ridker, P.M.; MacFadyen, J.G.; Nordestgaard, Børge G et al.

In: Circulation. Cardiovascular Quality and Outcomes, Vol. 3, No. 5, 09.2010, p. 447-52.

Research output: Contribution to journal › Journal article › Research › peer-review

Ridker, PM, MacFadyen, JG, Nordestgaard, BG, Koenig, W, Kastelein, JJP, Genest, J, Glynn, RJ, Ridker, PM, Macfadyen, JG, Koenig, W, Kastelein, JJP, Genest, J & Glynn, RJ 2010, 'Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk"', Circulation. Cardiovascular Quality and Outcomes, vol. 3, no. 5, pp. 447-52. https://doi.org/10.1161/CIRCOUTCOMES.110.938118

Ridker PM, MacFadyen JG, Nordestgaard BG, Koenig W, Kastelein JJP, Genest J et al. Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk". Circulation. Cardiovascular Quality and Outcomes. 2010 Sept;3(5):447-52. doi: http://dx.doi.org/10.1161/CIRCOUTCOMES.110.938118

Ridker, P.M. ; MacFadyen, J.G. ; Nordestgaard, Børge G et al. / Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention : an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk". In: Circulation. Cardiovascular Quality and Outcomes. 2010 ; Vol. 3, No. 5. pp. 447-52.

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title = "Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for {"}intermediate risk{"}",

abstract = "Background: Recent primary prevention guidelines issued in Canada endorse the use of statin therapy among individuals at {"}intermediate risk{"} who have elevated levels of high-sensitivity C-reactive protein (hsCRP). However, trial data directly addressing whether this recommendation defines a patient population in which statin therapy is effective have not previously been published. Methods and Results: In the Justification for Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial, which demonstrated a 44% reduction in first vascular events when rosuvastatin 20 mg was compared with placebo among 17 802 primary prevention patients with LDL cholesterol <130 mg/dL and hsCRP ≥2 mg/L, 6091 participants (2525 women, 3566 men) had baseline estimated 10-year Framingham risks of 5% to 10% and 7340 participants (1404 women, 5936 men) had baseline estimated Framingham risk of 11% to 20%. In these 2 {"}intermediate risk{"} subgroups, relative risk reductions consistent with the overall trial treatment effect were observed (hazard ratio, 0.55; 95% confidence interval, 0.36 to 0.84; 5-year number needed to treat=40, P=0.005 for those with 5% to 10% risk; hazard ratio, 0.51; 95% confidence interval, 0.39 to 0.68, 5-year number needed to treat=18, P<0.0001 for those with 11% to 20% risk). Use of the Reynolds Risk Score to stratify the study population gave similar results but reclassified large numbers of individuals into lower-or higher-risk groups. The majority of women with elevated hsCRP who benefited from rosuvastatin were at 5% to 10% 10-year risk at study entry using either global risk scoring system. Conclusions: Consistent with recent evidence-based Canadian Cardiovascular Society guidelines for primary prevention, the JUPITER trial demonstrates that rosuvastatin 20 mg significantly reduces major cardiovascular events among men and women with elevated hsCRP and {"}intermediate risk{"} defined either as 5% to 10% or 10% to 20% 10-year risk. Clinical Trial Registration: URL: http:// clinicaltrials.gov. Unique identifier: NCT00239681.",

author = "P.M. Ridker and J.G. MacFadyen and Nordestgaard, {B{\o}rge G} and W. Koenig and J.J.P. Kastelein and J. Genest and R.J. Glynn and Ridker, {Paul M} and Macfadyen, {Jean G} and Wolfgang Koenig and Kastelein, {John J P} and Jacques Genest and Glynn, {Robert J}",

year = "2010",

month = sep,

doi = "http://dx.doi.org/10.1161/CIRCOUTCOMES.110.938118",

language = "English",

volume = "3",

pages = "447--52",

journal = "Circulation: Cardiovascular Quality and Outcomes",

issn = "1941-7713",

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TY - JOUR

T1 - Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention

T2 - an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk"

AU - Ridker, P.M.

AU - MacFadyen, J.G.

AU - Nordestgaard, Børge G

AU - Koenig, W.

AU - Kastelein, J.J.P.

AU - Genest, J.

AU - Glynn, R.J.

AU - Ridker, Paul M

AU - Macfadyen, Jean G

AU - Koenig, Wolfgang

AU - Kastelein, John J P

AU - Genest, Jacques

AU - Glynn, Robert J

PY - 2010/9

Y1 - 2010/9

N2 - Background: Recent primary prevention guidelines issued in Canada endorse the use of statin therapy among individuals at "intermediate risk" who have elevated levels of high-sensitivity C-reactive protein (hsCRP). However, trial data directly addressing whether this recommendation defines a patient population in which statin therapy is effective have not previously been published. Methods and Results: In the Justification for Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial, which demonstrated a 44% reduction in first vascular events when rosuvastatin 20 mg was compared with placebo among 17 802 primary prevention patients with LDL cholesterol <130 mg/dL and hsCRP ≥2 mg/L, 6091 participants (2525 women, 3566 men) had baseline estimated 10-year Framingham risks of 5% to 10% and 7340 participants (1404 women, 5936 men) had baseline estimated Framingham risk of 11% to 20%. In these 2 "intermediate risk" subgroups, relative risk reductions consistent with the overall trial treatment effect were observed (hazard ratio, 0.55; 95% confidence interval, 0.36 to 0.84; 5-year number needed to treat=40, P=0.005 for those with 5% to 10% risk; hazard ratio, 0.51; 95% confidence interval, 0.39 to 0.68, 5-year number needed to treat=18, P<0.0001 for those with 11% to 20% risk). Use of the Reynolds Risk Score to stratify the study population gave similar results but reclassified large numbers of individuals into lower-or higher-risk groups. The majority of women with elevated hsCRP who benefited from rosuvastatin were at 5% to 10% 10-year risk at study entry using either global risk scoring system. Conclusions: Consistent with recent evidence-based Canadian Cardiovascular Society guidelines for primary prevention, the JUPITER trial demonstrates that rosuvastatin 20 mg significantly reduces major cardiovascular events among men and women with elevated hsCRP and "intermediate risk" defined either as 5% to 10% or 10% to 20% 10-year risk. Clinical Trial Registration: URL: http:// clinicaltrials.gov. Unique identifier: NCT00239681.

AB - Background: Recent primary prevention guidelines issued in Canada endorse the use of statin therapy among individuals at "intermediate risk" who have elevated levels of high-sensitivity C-reactive protein (hsCRP). However, trial data directly addressing whether this recommendation defines a patient population in which statin therapy is effective have not previously been published. Methods and Results: In the Justification for Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial, which demonstrated a 44% reduction in first vascular events when rosuvastatin 20 mg was compared with placebo among 17 802 primary prevention patients with LDL cholesterol <130 mg/dL and hsCRP ≥2 mg/L, 6091 participants (2525 women, 3566 men) had baseline estimated 10-year Framingham risks of 5% to 10% and 7340 participants (1404 women, 5936 men) had baseline estimated Framingham risk of 11% to 20%. In these 2 "intermediate risk" subgroups, relative risk reductions consistent with the overall trial treatment effect were observed (hazard ratio, 0.55; 95% confidence interval, 0.36 to 0.84; 5-year number needed to treat=40, P=0.005 for those with 5% to 10% risk; hazard ratio, 0.51; 95% confidence interval, 0.39 to 0.68, 5-year number needed to treat=18, P<0.0001 for those with 11% to 20% risk). Use of the Reynolds Risk Score to stratify the study population gave similar results but reclassified large numbers of individuals into lower-or higher-risk groups. The majority of women with elevated hsCRP who benefited from rosuvastatin were at 5% to 10% 10-year risk at study entry using either global risk scoring system. Conclusions: Consistent with recent evidence-based Canadian Cardiovascular Society guidelines for primary prevention, the JUPITER trial demonstrates that rosuvastatin 20 mg significantly reduces major cardiovascular events among men and women with elevated hsCRP and "intermediate risk" defined either as 5% to 10% or 10% to 20% 10-year risk. Clinical Trial Registration: URL: http:// clinicaltrials.gov. Unique identifier: NCT00239681.

U2 - http://dx.doi.org/10.1161/CIRCOUTCOMES.110.938118

DO - http://dx.doi.org/10.1161/CIRCOUTCOMES.110.938118

M3 - Journal article

SN - 1941-7713

VL - 3

SP - 447

EP - 452

JO - Circulation: Cardiovascular Quality and Outcomes

JF - Circulation: Cardiovascular Quality and Outcomes

IS - 5

ER -