Retrograde transport of protein toxins through the Golgi apparatus

Kirsten Sandvig; Tore Skotland; Bo van Deurs; Tove Irene Klokk

doi:10.1007/s00418-013-1111-z

Retrograde transport of protein toxins through the Golgi apparatus

Kirsten Sandvig, Tore Skotland, Bo van Deurs, Tove Irene Klokk

Morphogenesis and Differentiation Program

59 Citations (Scopus)

Abstract

A number of protein toxins from plants and bacteria take advantage of transport through the Golgi apparatus to gain entry into the cytosol where they exert their action. These toxins include the plant toxin ricin, the bacterial Shiga toxins, and cholera toxin. Such toxins bind to lipids or proteins at the cell surface, and they are endocytosed both by clathrin-dependent and clathrin-independent mechanisms. Sorting to the Golgi and retrograde transport to the endoplasmic reticulum (ER) are common to these toxins, but the exact mechanisms turn out to be toxin and cell-type dependent. In the ER, the enzymatically active part is released and then transported into the cytosol, exploiting components of the ER-associated degradation system. In this review, we will discuss transport of different protein toxins, but we will focus on factors involved in entry and sorting of ricin and Shiga toxin into and through the Golgi apparatus.

Original language	English
Journal	Histochemistry and Cell Biology
Volume	140
Issue number	3
Pages (from-to)	317-327
Number of pages	11
ISSN	0948-6143
DOIs	https://doi.org/10.1007/s00418-013-1111-z
Publication status	Published - Sept 2013

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title = "Retrograde transport of protein toxins through the Golgi apparatus",

abstract = "A number of protein toxins from plants and bacteria take advantage of transport through the Golgi apparatus to gain entry into the cytosol where they exert their action. These toxins include the plant toxin ricin, the bacterial Shiga toxins, and cholera toxin. Such toxins bind to lipids or proteins at the cell surface, and they are endocytosed both by clathrin-dependent and clathrin-independent mechanisms. Sorting to the Golgi and retrograde transport to the endoplasmic reticulum (ER) are common to these toxins, but the exact mechanisms turn out to be toxin and cell-type dependent. In the ER, the enzymatically active part is released and then transported into the cytosol, exploiting components of the ER-associated degradation system. In this review, we will discuss transport of different protein toxins, but we will focus on factors involved in entry and sorting of ricin and Shiga toxin into and through the Golgi apparatus.",

author = "Kirsten Sandvig and Tore Skotland and {van Deurs}, Bo and Klokk, {Tove Irene}",

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T1 - Retrograde transport of protein toxins through the Golgi apparatus

AU - Sandvig, Kirsten

AU - Skotland, Tore

AU - van Deurs, Bo

AU - Klokk, Tove Irene

PY - 2013/9

Y1 - 2013/9

N2 - A number of protein toxins from plants and bacteria take advantage of transport through the Golgi apparatus to gain entry into the cytosol where they exert their action. These toxins include the plant toxin ricin, the bacterial Shiga toxins, and cholera toxin. Such toxins bind to lipids or proteins at the cell surface, and they are endocytosed both by clathrin-dependent and clathrin-independent mechanisms. Sorting to the Golgi and retrograde transport to the endoplasmic reticulum (ER) are common to these toxins, but the exact mechanisms turn out to be toxin and cell-type dependent. In the ER, the enzymatically active part is released and then transported into the cytosol, exploiting components of the ER-associated degradation system. In this review, we will discuss transport of different protein toxins, but we will focus on factors involved in entry and sorting of ricin and Shiga toxin into and through the Golgi apparatus.

AB - A number of protein toxins from plants and bacteria take advantage of transport through the Golgi apparatus to gain entry into the cytosol where they exert their action. These toxins include the plant toxin ricin, the bacterial Shiga toxins, and cholera toxin. Such toxins bind to lipids or proteins at the cell surface, and they are endocytosed both by clathrin-dependent and clathrin-independent mechanisms. Sorting to the Golgi and retrograde transport to the endoplasmic reticulum (ER) are common to these toxins, but the exact mechanisms turn out to be toxin and cell-type dependent. In the ER, the enzymatically active part is released and then transported into the cytosol, exploiting components of the ER-associated degradation system. In this review, we will discuss transport of different protein toxins, but we will focus on factors involved in entry and sorting of ricin and Shiga toxin into and through the Golgi apparatus.

U2 - 10.1007/s00418-013-1111-z

DO - 10.1007/s00418-013-1111-z

M3 - Journal article

C2 - 23765164

SN - 0948-6143

VL - 140

SP - 317

EP - 327

JO - Histochemistry and Cell Biology

JF - Histochemistry and Cell Biology

IS - 3

ER -

Retrograde transport of protein toxins through the Golgi apparatus

Abstract

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