Reduced mortality and CD4 cell loss among carriers of the interleukin-10 -1082G allele in a Zimbabwean cohort of HIV-1-infected adults

Christian Erikstrup; Per Kallestrup; Rutendo B Zinyama-Gutsire; Exnevia Gomo; Anthony E Butterworth; Bente K Pedersen; Sisse R Ostrowski; Jan Gerstoft; Henrik Ullum

doi:10.1097/QAD.0b013e3282f153ed

Reduced mortality and CD4 cell loss among carriers of the interleukin-10 -1082G allele in a Zimbabwean cohort of HIV-1-infected adults

Christian Erikstrup, Per Kallestrup, Rutendo B Zinyama-Gutsire, Exnevia Gomo, Anthony E Butterworth, Bente K Pedersen, Sisse R Ostrowski, Jan Gerstoft, Henrik Ullum

38 Citations (Scopus)

Abstract

To evaluate the effect on HIV progression of single nucleotide polymorphisms in promoters of the genes for tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 and known to influence cytokine production.

Original language	English
Journal	AIDS
Volume	21
Issue number	17
Pages (from-to)	2283-91
Number of pages	9
ISSN	0269-9370
DOIs	https://doi.org/10.1097/QAD.0b013e3282f153ed
Publication status	Published - 2007

Keywords

Adult
Alleles
Analysis of Variance
Biological Markers
CD4 Lymphocyte Count
Case-Control Studies
Developing Countries
Disease Progression
Female
HIV Infections
HIV-1
Haplotypes
Heterozygote
Humans
Interleukin-10
Interleukin-8
Male
Middle Aged
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Proportional Hazards Models
RNA, Viral
Receptors, Tumor Necrosis Factor, Type II
Survival Rate
Tumor Necrosis Factor-alpha
Virus Replication
Zimbabwe

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/QAD.0b013e3282f153ed

Cite this

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title = "Reduced mortality and CD4 cell loss among carriers of the interleukin-10 -1082G allele in a Zimbabwean cohort of HIV-1-infected adults",

abstract = "To evaluate the effect on HIV progression of single nucleotide polymorphisms in promoters of the genes for tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 and known to influence cytokine production.",

keywords = "Adult, Alleles, Analysis of Variance, Biological Markers, CD4 Lymphocyte Count, Case-Control Studies, Developing Countries, Disease Progression, Female, HIV Infections, HIV-1, Haplotypes, Heterozygote, Humans, Interleukin-10, Interleukin-8, Male, Middle Aged, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Proportional Hazards Models, RNA, Viral, Receptors, Tumor Necrosis Factor, Type II, Survival Rate, Tumor Necrosis Factor-alpha, Virus Replication, Zimbabwe",

author = "Christian Erikstrup and Per Kallestrup and Zinyama-Gutsire, {Rutendo B} and Exnevia Gomo and Butterworth, {Anthony E} and Pedersen, {Bente K} and Ostrowski, {Sisse R} and Jan Gerstoft and Henrik Ullum",

year = "2007",

doi = "10.1097/QAD.0b013e3282f153ed",

language = "English",

volume = "21",

pages = "2283--91",

journal = "AIDS, Supplement",

issn = "1350-2840",

publisher = "Lippincott Williams & Wilkins",

number = "17",

}

TY - JOUR

T1 - Reduced mortality and CD4 cell loss among carriers of the interleukin-10 -1082G allele in a Zimbabwean cohort of HIV-1-infected adults

AU - Erikstrup, Christian

AU - Kallestrup, Per

AU - Zinyama-Gutsire, Rutendo B

AU - Gomo, Exnevia

AU - Butterworth, Anthony E

AU - Pedersen, Bente K

AU - Ostrowski, Sisse R

AU - Gerstoft, Jan

AU - Ullum, Henrik

PY - 2007

Y1 - 2007

N2 - To evaluate the effect on HIV progression of single nucleotide polymorphisms in promoters of the genes for tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 and known to influence cytokine production.

AB - To evaluate the effect on HIV progression of single nucleotide polymorphisms in promoters of the genes for tumour necrosis factor (TNF)-alpha and interleukin (IL)-10 and known to influence cytokine production.

KW - Adult

KW - Alleles

KW - Analysis of Variance

KW - Biological Markers

KW - CD4 Lymphocyte Count

KW - Case-Control Studies

KW - Developing Countries

KW - Disease Progression

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Haplotypes

KW - Heterozygote

KW - Humans

KW - Interleukin-10

KW - Interleukin-8

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

KW - Proportional Hazards Models

KW - RNA, Viral

KW - Receptors, Tumor Necrosis Factor, Type II

KW - Survival Rate

KW - Tumor Necrosis Factor-alpha

KW - Virus Replication

KW - Zimbabwe

U2 - 10.1097/QAD.0b013e3282f153ed

DO - 10.1097/QAD.0b013e3282f153ed

M3 - Journal article

C2 - 18090276

SN - 1350-2840

VL - 21

SP - 2283

EP - 2291

JO - AIDS, Supplement

JF - AIDS, Supplement

IS - 17

ER -

Reduced mortality and CD4 cell loss among carriers of the interleukin-10 -1082G allele in a Zimbabwean cohort of HIV-1-infected adults

Abstract

Keywords

UN SDGs

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