Reduced cellular immune reactivity in healthy individuals during the malaria transmission season

TY - JOUR

T1 - Reduced cellular immune reactivity in healthy individuals during the malaria transmission season

AU - Theander, T G

AU - Hviid, L

AU - Abu-Zeid, Y A

AU - Abdulhadi, N H

AU - Saeed, B O

AU - Jakobsen, P H

AU - Reimert, C M

AU - Jepsen, S

AU - Bayoumi, R A

AU - Jensen, J B

N1 - Keywords: Adolescent; Adult; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; Child; Child, Preschool; Female; Humans; Lymphocyte Activation; Malaria; Male; Middle Aged; Phytohemagglutinins; Plasmodium; Protozoan Proteins; Seasons; Sudan; Tuberculin

PY - 1990

Y1 - 1990

N2 - Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.

AB - Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.

M3 - Journal article

C2 - 2283153

SN - 0165-2478

VL - 25

SP - 237

EP - 242

JO - Immunology Letters

JF - Immunology Letters

IS - 1-3

ER -