Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

Pernille Lund; Per Torp Sangild; L. Aunsholt; Bolette Hartmann; Jens Juul Holst; J. Mortensen; P.B. Mortensen; P.B. Jeppesen

doi:10.1038/ejcn.2012.93

Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

Pernille Lund, Per Torp Sangild, L. Aunsholt, Bolette Hartmann, Jens Juul Holst, J. Mortensen, P.B. Mortensen, P.B. Jeppesen

Endocrinology and Metabolism

17 Citations (Scopus)

Abstract

Background/Objectives:Colostrum is rich in immunoregulatory, antimicrobial and trophic components supporting intestinal development and function in newborns. We assessed whether bovine colostrum could enhance intestinal adaptation and function in adult short bowel syndrome (SBS) patients.Subjects/ Methods:Twelve SBS patients in this randomised cross-over study received 4 weeks oral supplement of bovine colostrum or an iso-energetic and iso-proteinaceous control (2.4 MJ/d, 500 ml/day) separated by a 4-week washout period. Patients were admitted four times for 72-h periods of fluid, electrolyte and nutrient balance studies. Meals, faeces and urine were weighed, and energy, macronutrient and electrolyte contents were analysed to calculate net nutrient uptake. Body composition was measured by dual-energy X-ray absorptiometry scans, and functional tests of handgrip strength and lung functions were performed. Eight patients completed the study and were included in the analysis.Results:Both supplements (colostrum and control) not only increased protein (0.960.42 MJ/d, P0.004 1.030.44 MJ/d, P0.003) and energy (1.461.02 MJ/d, P0.005, 1.761.46 MJ/d, P0.01) absorption but also absolute faecal wet weight excretions (231248 g/d, P0.002, 319299 g/d, P0.03), compared with baseline measurements. Both supplements improved handgrip strength (P0.03) while only the control supplement increased lean body mass (1.121.33 kg, P0.049). Colostrum was not found to be superior to the control.Conclusion:Intake of high-protein milk supplements increased net nutrient absorption for adult SBS patients, but at the expense of increased diarrhoea. Despite high contents of bioactive factors, colostrum did not significantly improve intestinal absorption, body composition or functional tests compared with the control.

Original language	English
Journal	European Journal of Clinical Nutrition
Volume	66
Issue number	9
Pages (from-to)	1059-1065
Number of pages	7
ISSN	0954-3007
DOIs	https://doi.org/10.1038/ejcn.2012.93
Publication status	Published - Sept 2012

Keywords

Animals
Basal Metabolism
Body Composition
Cattle
Colostrum
Cross-Over Studies
Double-Blind Method
Energy Intake
Feces
Female
Hand Strength
Humans
Intestinal Absorption
Male
Middle Aged
Respiratory Function Tests
Short Bowel Syndrome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ejcn.2012.93

https://www.nature.com/articles/ejcn201293.pdf

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@article{0a38639f626d4d898289bce9aaab50c8,

title = "Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome",

abstract = "Background/Objectives:Colostrum is rich in immunoregulatory, antimicrobial and trophic components supporting intestinal development and function in newborns. We assessed whether bovine colostrum could enhance intestinal adaptation and function in adult short bowel syndrome (SBS) patients.Subjects/ Methods:Twelve SBS patients in this randomised cross-over study received 4 weeks oral supplement of bovine colostrum or an iso-energetic and iso-proteinaceous control (2.4 MJ/d, 500 ml/day) separated by a 4-week washout period. Patients were admitted four times for 72-h periods of fluid, electrolyte and nutrient balance studies. Meals, faeces and urine were weighed, and energy, macronutrient and electrolyte contents were analysed to calculate net nutrient uptake. Body composition was measured by dual-energy X-ray absorptiometry scans, and functional tests of handgrip strength and lung functions were performed. Eight patients completed the study and were included in the analysis.Results:Both supplements (colostrum and control) not only increased protein (0.960.42 MJ/d, P0.004 1.030.44 MJ/d, P0.003) and energy (1.461.02 MJ/d, P0.005, 1.761.46 MJ/d, P0.01) absorption but also absolute faecal wet weight excretions (231248 g/d, P0.002, 319299 g/d, P0.03), compared with baseline measurements. Both supplements improved handgrip strength (P0.03) while only the control supplement increased lean body mass (1.121.33 kg, P0.049). Colostrum was not found to be superior to the control.Conclusion:Intake of high-protein milk supplements increased net nutrient absorption for adult SBS patients, but at the expense of increased diarrhoea. Despite high contents of bioactive factors, colostrum did not significantly improve intestinal absorption, body composition or functional tests compared with the control.",

keywords = "Animals, Basal Metabolism, Body Composition, Cattle, Colostrum, Cross-Over Studies, Double-Blind Method, Energy Intake, Feces, Female, Hand Strength, Humans, Intestinal Absorption, Male, Middle Aged, Respiratory Function Tests, Short Bowel Syndrome",

author = "Pernille Lund and Sangild, {Per Torp} and L. Aunsholt and Bolette Hartmann and Holst, {Jens Juul} and J. Mortensen and P.B. Mortensen and P.B. Jeppesen",

year = "2012",

month = sep,

doi = "10.1038/ejcn.2012.93",

language = "English",

volume = "66",

pages = "1059--1065",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "nature publishing group",

number = "9",

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TY - JOUR

T1 - Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

AU - Lund, Pernille

AU - Sangild, Per Torp

AU - Aunsholt, L.

AU - Hartmann, Bolette

AU - Holst, Jens Juul

AU - Mortensen, J.

AU - Mortensen, P.B.

AU - Jeppesen, P.B.

PY - 2012/9

Y1 - 2012/9

N2 - Background/Objectives:Colostrum is rich in immunoregulatory, antimicrobial and trophic components supporting intestinal development and function in newborns. We assessed whether bovine colostrum could enhance intestinal adaptation and function in adult short bowel syndrome (SBS) patients.Subjects/ Methods:Twelve SBS patients in this randomised cross-over study received 4 weeks oral supplement of bovine colostrum or an iso-energetic and iso-proteinaceous control (2.4 MJ/d, 500 ml/day) separated by a 4-week washout period. Patients were admitted four times for 72-h periods of fluid, electrolyte and nutrient balance studies. Meals, faeces and urine were weighed, and energy, macronutrient and electrolyte contents were analysed to calculate net nutrient uptake. Body composition was measured by dual-energy X-ray absorptiometry scans, and functional tests of handgrip strength and lung functions were performed. Eight patients completed the study and were included in the analysis.Results:Both supplements (colostrum and control) not only increased protein (0.960.42 MJ/d, P0.004 1.030.44 MJ/d, P0.003) and energy (1.461.02 MJ/d, P0.005, 1.761.46 MJ/d, P0.01) absorption but also absolute faecal wet weight excretions (231248 g/d, P0.002, 319299 g/d, P0.03), compared with baseline measurements. Both supplements improved handgrip strength (P0.03) while only the control supplement increased lean body mass (1.121.33 kg, P0.049). Colostrum was not found to be superior to the control.Conclusion:Intake of high-protein milk supplements increased net nutrient absorption for adult SBS patients, but at the expense of increased diarrhoea. Despite high contents of bioactive factors, colostrum did not significantly improve intestinal absorption, body composition or functional tests compared with the control.

AB - Background/Objectives:Colostrum is rich in immunoregulatory, antimicrobial and trophic components supporting intestinal development and function in newborns. We assessed whether bovine colostrum could enhance intestinal adaptation and function in adult short bowel syndrome (SBS) patients.Subjects/ Methods:Twelve SBS patients in this randomised cross-over study received 4 weeks oral supplement of bovine colostrum or an iso-energetic and iso-proteinaceous control (2.4 MJ/d, 500 ml/day) separated by a 4-week washout period. Patients were admitted four times for 72-h periods of fluid, electrolyte and nutrient balance studies. Meals, faeces and urine were weighed, and energy, macronutrient and electrolyte contents were analysed to calculate net nutrient uptake. Body composition was measured by dual-energy X-ray absorptiometry scans, and functional tests of handgrip strength and lung functions were performed. Eight patients completed the study and were included in the analysis.Results:Both supplements (colostrum and control) not only increased protein (0.960.42 MJ/d, P0.004 1.030.44 MJ/d, P0.003) and energy (1.461.02 MJ/d, P0.005, 1.761.46 MJ/d, P0.01) absorption but also absolute faecal wet weight excretions (231248 g/d, P0.002, 319299 g/d, P0.03), compared with baseline measurements. Both supplements improved handgrip strength (P0.03) while only the control supplement increased lean body mass (1.121.33 kg, P0.049). Colostrum was not found to be superior to the control.Conclusion:Intake of high-protein milk supplements increased net nutrient absorption for adult SBS patients, but at the expense of increased diarrhoea. Despite high contents of bioactive factors, colostrum did not significantly improve intestinal absorption, body composition or functional tests compared with the control.

KW - Animals

KW - Basal Metabolism

KW - Body Composition

KW - Cattle

KW - Colostrum

KW - Cross-Over Studies

KW - Double-Blind Method

KW - Energy Intake

KW - Feces

KW - Female

KW - Hand Strength

KW - Humans

KW - Intestinal Absorption

KW - Male

KW - Middle Aged

KW - Respiratory Function Tests

KW - Short Bowel Syndrome

U2 - 10.1038/ejcn.2012.93

DO - 10.1038/ejcn.2012.93

M3 - Journal article

C2 - 22828734

SN - 0954-3007

VL - 66

SP - 1059

EP - 1065

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 9

ER -

Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome

Abstract

Keywords

UN SDGs

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