Preschool Weight and Body Mass Index in Relation to Central Obesity and Metabolic Syndrome in Adulthood

Lise Graversen; Thorkild I A Sørensen; Liselotte Petersen; Ulla Sovio; Marika Kaakinen; Annelli Sandbaek; Jaana Laitinen; Anja Taanila; Anneli Pouta; Marjo-Riitta Järvelin; Carsten Obel

doi:10.1371/journal.pone.0089986

Preschool Weight and Body Mass Index in Relation to Central Obesity and Metabolic Syndrome in Adulthood

Lise Graversen, Thorkild I A Sørensen, Liselotte Petersen, Ulla Sovio, Marika Kaakinen, Annelli Sandbaek, Jaana Laitinen, Anja Taanila, Anneli Pouta, Marjo-Riitta Järvelin, Carsten Obel

Department of Public Health

32 Citations (Scopus)

Abstract

BACKGROUND: If preschool measures of body size routinely collected at preventive health examinations are associated with adult central obesity and metabolic syndrome, a focused use of these data for the identification of high risk children is possible. The aim of this study was to test the associations between preschool weight and body mass index (BMI) and adult BMI, central obesity and metabolic alterations.

METHODS: The Northern Finland Birth Cohort 1966 (NFBC1966) (N = 4111) is a population-based cohort. Preschool weight (age 5 months and 1 year) and BMI (age 2-5 years) were studied in relation to metabolic syndrome as well as BMI, waist circumference, lipoproteins, blood pressure, and fasting glucose at the age of 31 years. Linear regression models and generalized linear regression models with log link were used.

RESULTS: Throughout preschool ages, weight and BMI were significantly linearly associated with adult BMI and waist circumference. Preschool BMI was inversely associated with high-density lipoprotein levels from the age of 3 years. Compared with children in the lower half of the BMI range, the group of children with the 5% highest BMI at the age of 5 years had a relative risk of adult obesity of 6.2(95% CI:4.2-9.3), of adult central obesity of 2.4(95% CI:2.0-2.9), and of early onset adult metabolic syndrome of 2.5(95% CI:1.7-3.8).

CONCLUSIONS: High preschool BMI is consistently associated with adult obesity, central obesity and early onset metabolic syndrome. Routinely collected measures of body size in preschool ages can help to identify children in need of focused prevention due to their increased risk of adverse metabolic alterations in adulthood.

Original language	English
Article number	e89986
Journal	PLOS ONE
Volume	9
Issue number	3
Pages (from-to)	1-9
Number of pages	9
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0089986
Publication status	Published - 3 Mar 2014

Keywords

Body Mass Index
Body Weight
Child, Preschool
Cohort Studies
Finland
Humans
Metabolic Syndrome X
Obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0089986

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@article{46815b2166ec47ea9a268ab63efce33e,

title = "Preschool Weight and Body Mass Index in Relation to Central Obesity and Metabolic Syndrome in Adulthood",

abstract = "BACKGROUND: If preschool measures of body size routinely collected at preventive health examinations are associated with adult central obesity and metabolic syndrome, a focused use of these data for the identification of high risk children is possible. The aim of this study was to test the associations between preschool weight and body mass index (BMI) and adult BMI, central obesity and metabolic alterations.METHODS: The Northern Finland Birth Cohort 1966 (NFBC1966) (N = 4111) is a population-based cohort. Preschool weight (age 5 months and 1 year) and BMI (age 2-5 years) were studied in relation to metabolic syndrome as well as BMI, waist circumference, lipoproteins, blood pressure, and fasting glucose at the age of 31 years. Linear regression models and generalized linear regression models with log link were used.RESULTS: Throughout preschool ages, weight and BMI were significantly linearly associated with adult BMI and waist circumference. Preschool BMI was inversely associated with high-density lipoprotein levels from the age of 3 years. Compared with children in the lower half of the BMI range, the group of children with the 5% highest BMI at the age of 5 years had a relative risk of adult obesity of 6.2(95% CI:4.2-9.3), of adult central obesity of 2.4(95% CI:2.0-2.9), and of early onset adult metabolic syndrome of 2.5(95% CI:1.7-3.8).CONCLUSIONS: High preschool BMI is consistently associated with adult obesity, central obesity and early onset metabolic syndrome. Routinely collected measures of body size in preschool ages can help to identify children in need of focused prevention due to their increased risk of adverse metabolic alterations in adulthood.",

keywords = "Body Mass Index, Body Weight, Child, Preschool, Cohort Studies, Finland, Humans, Metabolic Syndrome X, Obesity",

author = "Lise Graversen and S{\o}rensen, {Thorkild I A} and Liselotte Petersen and Ulla Sovio and Marika Kaakinen and Annelli Sandbaek and Jaana Laitinen and Anja Taanila and Anneli Pouta and Marjo-Riitta J{\"a}rvelin and Carsten Obel",

year = "2014",

month = mar,

day = "3",

doi = "10.1371/journal.pone.0089986",

language = "English",

volume = "9",

pages = "1--9",

journal = "PLoS Computational Biology",

issn = "1932-6203",

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TY - JOUR

T1 - Preschool Weight and Body Mass Index in Relation to Central Obesity and Metabolic Syndrome in Adulthood

AU - Graversen, Lise

AU - Sørensen, Thorkild I A

AU - Petersen, Liselotte

AU - Sovio, Ulla

AU - Kaakinen, Marika

AU - Sandbaek, Annelli

AU - Laitinen, Jaana

AU - Taanila, Anja

AU - Pouta, Anneli

AU - Järvelin, Marjo-Riitta

AU - Obel, Carsten

PY - 2014/3/3

Y1 - 2014/3/3

N2 - BACKGROUND: If preschool measures of body size routinely collected at preventive health examinations are associated with adult central obesity and metabolic syndrome, a focused use of these data for the identification of high risk children is possible. The aim of this study was to test the associations between preschool weight and body mass index (BMI) and adult BMI, central obesity and metabolic alterations.METHODS: The Northern Finland Birth Cohort 1966 (NFBC1966) (N = 4111) is a population-based cohort. Preschool weight (age 5 months and 1 year) and BMI (age 2-5 years) were studied in relation to metabolic syndrome as well as BMI, waist circumference, lipoproteins, blood pressure, and fasting glucose at the age of 31 years. Linear regression models and generalized linear regression models with log link were used.RESULTS: Throughout preschool ages, weight and BMI were significantly linearly associated with adult BMI and waist circumference. Preschool BMI was inversely associated with high-density lipoprotein levels from the age of 3 years. Compared with children in the lower half of the BMI range, the group of children with the 5% highest BMI at the age of 5 years had a relative risk of adult obesity of 6.2(95% CI:4.2-9.3), of adult central obesity of 2.4(95% CI:2.0-2.9), and of early onset adult metabolic syndrome of 2.5(95% CI:1.7-3.8).CONCLUSIONS: High preschool BMI is consistently associated with adult obesity, central obesity and early onset metabolic syndrome. Routinely collected measures of body size in preschool ages can help to identify children in need of focused prevention due to their increased risk of adverse metabolic alterations in adulthood.

AB - BACKGROUND: If preschool measures of body size routinely collected at preventive health examinations are associated with adult central obesity and metabolic syndrome, a focused use of these data for the identification of high risk children is possible. The aim of this study was to test the associations between preschool weight and body mass index (BMI) and adult BMI, central obesity and metabolic alterations.METHODS: The Northern Finland Birth Cohort 1966 (NFBC1966) (N = 4111) is a population-based cohort. Preschool weight (age 5 months and 1 year) and BMI (age 2-5 years) were studied in relation to metabolic syndrome as well as BMI, waist circumference, lipoproteins, blood pressure, and fasting glucose at the age of 31 years. Linear regression models and generalized linear regression models with log link were used.RESULTS: Throughout preschool ages, weight and BMI were significantly linearly associated with adult BMI and waist circumference. Preschool BMI was inversely associated with high-density lipoprotein levels from the age of 3 years. Compared with children in the lower half of the BMI range, the group of children with the 5% highest BMI at the age of 5 years had a relative risk of adult obesity of 6.2(95% CI:4.2-9.3), of adult central obesity of 2.4(95% CI:2.0-2.9), and of early onset adult metabolic syndrome of 2.5(95% CI:1.7-3.8).CONCLUSIONS: High preschool BMI is consistently associated with adult obesity, central obesity and early onset metabolic syndrome. Routinely collected measures of body size in preschool ages can help to identify children in need of focused prevention due to their increased risk of adverse metabolic alterations in adulthood.

KW - Body Mass Index

KW - Body Weight

KW - Child, Preschool

KW - Cohort Studies

KW - Finland

KW - Humans

KW - Metabolic Syndrome X

KW - Obesity

U2 - 10.1371/journal.pone.0089986

DO - 10.1371/journal.pone.0089986

M3 - Journal article

C2 - 24595022

SN - 1932-6203

VL - 9

SP - 1

EP - 9

JO - PLoS Computational Biology

JF - PLoS Computational Biology

IS - 3

M1 - e89986

ER -

Preschool Weight and Body Mass Index in Relation to Central Obesity and Metabolic Syndrome in Adulthood

Abstract

Keywords

UN SDGs

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