Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats

Oksana Dmytriyeva; Boris Klementiev; Vladimir Berezin; Elisabeth Bock

doi:10.1016/j.etp.2012.06.001

Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats

Oksana Dmytriyeva, Boris Klementiev, Vladimir Berezin, Elisabeth Bock

5 Citations (Scopus)

Abstract

Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.

Original language	English
Journal	Experimental and Toxicologic Pathology
Volume	65
Issue number	5
Pages (from-to)	591–593
Number of pages	5
ISSN	0940-2993
DOIs	https://doi.org/10.1016/j.etp.2012.06.001
Publication status	Published - Jul 2013

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Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats. / Dmytriyeva, Oksana; Klementiev, Boris; Berezin, Vladimir et al.

In: Experimental and Toxicologic Pathology, Vol. 65, No. 5, 07.2013, p. 591–593.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.",

author = "Oksana Dmytriyeva and Boris Klementiev and Vladimir Berezin and Elisabeth Bock",

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AU - Bock, Elisabeth

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AB - Metabolites of the commonly used imidazole fungicide prochloraz are androgen receptor antagonists. They have been shown to block androgen-driven development and compromise reproductive function. We tested the effect of prochloraz on cognitive behavior following exposure to this fungicide during the perinatal period. Pregnant Wistar rats were administered a 200mg/kg dose of prochloraz on gestational day (GD) 7, GD11, and GD15. The social recognition test (SRT) was performed on 7-week-old male rat offspring. We found an increase in pregnancy length and a significantly reduced pup weight on PND15 and PND40 but no effect of prenatal prochloraz exposure on social investigation or acquisition of social-olfactory memory.

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Prenatal prochloraz treatment significantly increases pregnancy length and reduces offspring weight but does not affect social-olfactory memory in rats

Abstract

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