Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis

Mireia Gascon; Jordi Sunyer; Maribel Casas; David Martínez; Ferran Ballester; Mikel Basterrechea; Jens Peter Bonde; Leda Chatzi; Cécile Chevrier; Merete Eggesbø; Ana Esplugues; Eva Govarts; Kiviranta Hannu; Jesús Ibarluzea; Monika Kasper-Sonnenberg; Claudia Klümper; Gudrun Koppen; Mark J Nieuwenhuijsen; Lubica Palkovicova; Fabienne Pelé; Anuschka Polder; Greet Schoeters; Maties Torrent; Tomas Trnovec; Maria Vassilaki; Martine Vrijheid

doi:10.1097/ede.0000000000000097

Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis

Mireia Gascon, Jordi Sunyer, Maribel Casas, David Martínez, Ferran Ballester, Mikel Basterrechea, Jens Peter Bonde, Leda Chatzi, Cécile Chevrier, Merete Eggesbø, Ana Esplugues, Eva Govarts, Kiviranta Hannu, Jesús Ibarluzea, Monika Kasper-Sonnenberg, Claudia Klümper, Gudrun Koppen, Mark J Nieuwenhuijsen, Lubica Palkovicova, Fabienne PeléAnuschka Polder, Greet Schoeters, Maties Torrent, Tomas Trnovec, Maria Vassilaki, Martine Vrijheid

24 Citations (Scopus)

Abstract

BACKGROUND: Persistent organic pollutants may affect the immune and respiratory systems, but available evidence is based on small study populations. We studied the association between prenatal exposure to dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyl 153 (PCB 153) and children's respiratory health in European birth cohorts.

METHODS: We included 4608 mothers and children enrolled in 10 birth cohort studies from 7 European countries. Outcomes were parent-reported bronchitis and wheeze in the first 4 years of life. For each cohort, we performed Poisson regression analyses, modeling occurrences of the outcomes on the estimates of cord-serum concentrations of PCB 153 and DDE as continuous variables (per doubling exposure) and as cohort-specific tertiles. Summary estimates were obtained through random-effects meta-analyses.

RESULTS: The risk of bronchitis or wheeze (combined variable) assessed before 18 months of age increased with increasing DDE exposure (relative risk [RR] per doubling exposure = 1.03 [95% confidence interval = 1.00-1.07]). When these outcomes were analyzed separately, associations appeared stronger for bronchitis. We also found an association between increasing PCB 153 exposure and bronchitis in this period (RR per doubling exposure = 1.06 [1.01-1.12]) but not between PCB 153 and wheeze. No associations were found between either DDE or PCB 153 and ever-wheeze assessed after 18 months. Inclusion of both compounds in the models attenuated risk estimates for PCB 153 tertiles of exposure, whereas DDE associations were more robust.

CONCLUSION: This large meta-analysis suggests that prenatal DDE exposure may be associated with respiratory health symptoms in young children (below 18 months), whereas prenatal PCB 153 levels were not associated with such symptoms.

Original language	English
Journal	Epidemiology (Cambridge, Mass.)
Volume	25
Issue number	4
Pages (from-to)	544-553
Number of pages	10
ISSN	1044-3983
DOIs	https://doi.org/10.1097/ede.0000000000000097
Publication status	Published - Jul 2014

Keywords

Adolescent
Adult
Bronchitis
Child, Preschool
Cohort Studies
Dichlorodiphenyl Dichloroethylene
Environmental Exposure
Europe
Female
Humans
Infant
Infant, Newborn
Male
Poisson Distribution
Polychlorinated Biphenyls
Pregnancy
Prenatal Exposure Delayed Effects
Respiratory Sounds
Respiratory Tract Diseases
Risk Factors
Young Adult

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10.1097/ede.0000000000000097

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Gascon, M., Sunyer, J., Casas, M., Martínez, D., Ballester, F., Basterrechea, M., Bonde, J. P., Chatzi, L., Chevrier, C., Eggesbø, M., Esplugues, A., Govarts, E., Hannu, K., Ibarluzea, J., Kasper-Sonnenberg, M., Klümper, C., Koppen, G., Nieuwenhuijsen, M. J., Palkovicova, L., ... Vrijheid, M. (2014). Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis. Epidemiology (Cambridge, Mass.), 25(4), 544-553. https://doi.org/10.1097/ede.0000000000000097

Gascon, M, Sunyer, J, Casas, M, Martínez, D, Ballester, F, Basterrechea, M, Bonde, JP, Chatzi, L, Chevrier, C, Eggesbø, M, Esplugues, A, Govarts, E, Hannu, K, Ibarluzea, J, Kasper-Sonnenberg, M, Klümper, C, Koppen, G, Nieuwenhuijsen, MJ, Palkovicova, L, Pelé, F, Polder, A, Schoeters, G, Torrent, M, Trnovec, T, Vassilaki, M & Vrijheid, M 2014, 'Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis', Epidemiology (Cambridge, Mass.), vol. 25, no. 4, pp. 544-553. https://doi.org/10.1097/ede.0000000000000097

@article{426358c899a744f7a9944e5a9af69cb1,

title = "Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis",

abstract = "BACKGROUND: Persistent organic pollutants may affect the immune and respiratory systems, but available evidence is based on small study populations. We studied the association between prenatal exposure to dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyl 153 (PCB 153) and children's respiratory health in European birth cohorts.METHODS: We included 4608 mothers and children enrolled in 10 birth cohort studies from 7 European countries. Outcomes were parent-reported bronchitis and wheeze in the first 4 years of life. For each cohort, we performed Poisson regression analyses, modeling occurrences of the outcomes on the estimates of cord-serum concentrations of PCB 153 and DDE as continuous variables (per doubling exposure) and as cohort-specific tertiles. Summary estimates were obtained through random-effects meta-analyses.RESULTS: The risk of bronchitis or wheeze (combined variable) assessed before 18 months of age increased with increasing DDE exposure (relative risk [RR] per doubling exposure = 1.03 [95% confidence interval = 1.00-1.07]). When these outcomes were analyzed separately, associations appeared stronger for bronchitis. We also found an association between increasing PCB 153 exposure and bronchitis in this period (RR per doubling exposure = 1.06 [1.01-1.12]) but not between PCB 153 and wheeze. No associations were found between either DDE or PCB 153 and ever-wheeze assessed after 18 months. Inclusion of both compounds in the models attenuated risk estimates for PCB 153 tertiles of exposure, whereas DDE associations were more robust.CONCLUSION: This large meta-analysis suggests that prenatal DDE exposure may be associated with respiratory health symptoms in young children (below 18 months), whereas prenatal PCB 153 levels were not associated with such symptoms.",

keywords = "Adolescent, Adult, Bronchitis, Child, Preschool, Cohort Studies, Dichlorodiphenyl Dichloroethylene, Environmental Exposure, Europe, Female, Humans, Infant, Infant, Newborn, Male, Poisson Distribution, Polychlorinated Biphenyls, Pregnancy, Prenatal Exposure Delayed Effects, Respiratory Sounds, Respiratory Tract Diseases, Risk Factors, Young Adult",

author = "Mireia Gascon and Jordi Sunyer and Maribel Casas and David Mart{\'i}nez and Ferran Ballester and Mikel Basterrechea and Bonde, {Jens Peter} and Leda Chatzi and C{\'e}cile Chevrier and Merete Eggesb{\o} and Ana Esplugues and Eva Govarts and Kiviranta Hannu and Jes{\'u}s Ibarluzea and Monika Kasper-Sonnenberg and Claudia Kl{\"u}mper and Gudrun Koppen and Nieuwenhuijsen, {Mark J} and Lubica Palkovicova and Fabienne Pel{\'e} and Anuschka Polder and Greet Schoeters and Maties Torrent and Tomas Trnovec and Maria Vassilaki and Martine Vrijheid",

year = "2014",

month = jul,

doi = "10.1097/ede.0000000000000097",

language = "English",

volume = "25",

pages = "544--553",

journal = "Epidemiology",

issn = "1044-3983",

publisher = "Lippincott Williams & Wilkins",

number = "4",

}

TY - JOUR

T1 - Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood

T2 - A Meta-Analysis

AU - Gascon, Mireia

AU - Sunyer, Jordi

AU - Casas, Maribel

AU - Martínez, David

AU - Ballester, Ferran

AU - Basterrechea, Mikel

AU - Bonde, Jens Peter

AU - Chatzi, Leda

AU - Chevrier, Cécile

AU - Eggesbø, Merete

AU - Esplugues, Ana

AU - Govarts, Eva

AU - Hannu, Kiviranta

AU - Ibarluzea, Jesús

AU - Kasper-Sonnenberg, Monika

AU - Klümper, Claudia

AU - Koppen, Gudrun

AU - Nieuwenhuijsen, Mark J

AU - Palkovicova, Lubica

AU - Pelé, Fabienne

AU - Polder, Anuschka

AU - Schoeters, Greet

AU - Torrent, Maties

AU - Trnovec, Tomas

AU - Vassilaki, Maria

AU - Vrijheid, Martine

PY - 2014/7

Y1 - 2014/7

N2 - BACKGROUND: Persistent organic pollutants may affect the immune and respiratory systems, but available evidence is based on small study populations. We studied the association between prenatal exposure to dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyl 153 (PCB 153) and children's respiratory health in European birth cohorts.METHODS: We included 4608 mothers and children enrolled in 10 birth cohort studies from 7 European countries. Outcomes were parent-reported bronchitis and wheeze in the first 4 years of life. For each cohort, we performed Poisson regression analyses, modeling occurrences of the outcomes on the estimates of cord-serum concentrations of PCB 153 and DDE as continuous variables (per doubling exposure) and as cohort-specific tertiles. Summary estimates were obtained through random-effects meta-analyses.RESULTS: The risk of bronchitis or wheeze (combined variable) assessed before 18 months of age increased with increasing DDE exposure (relative risk [RR] per doubling exposure = 1.03 [95% confidence interval = 1.00-1.07]). When these outcomes were analyzed separately, associations appeared stronger for bronchitis. We also found an association between increasing PCB 153 exposure and bronchitis in this period (RR per doubling exposure = 1.06 [1.01-1.12]) but not between PCB 153 and wheeze. No associations were found between either DDE or PCB 153 and ever-wheeze assessed after 18 months. Inclusion of both compounds in the models attenuated risk estimates for PCB 153 tertiles of exposure, whereas DDE associations were more robust.CONCLUSION: This large meta-analysis suggests that prenatal DDE exposure may be associated with respiratory health symptoms in young children (below 18 months), whereas prenatal PCB 153 levels were not associated with such symptoms.

AB - BACKGROUND: Persistent organic pollutants may affect the immune and respiratory systems, but available evidence is based on small study populations. We studied the association between prenatal exposure to dichlorodiphenyldichloroethylene (DDE) and polychlorinated biphenyl 153 (PCB 153) and children's respiratory health in European birth cohorts.METHODS: We included 4608 mothers and children enrolled in 10 birth cohort studies from 7 European countries. Outcomes were parent-reported bronchitis and wheeze in the first 4 years of life. For each cohort, we performed Poisson regression analyses, modeling occurrences of the outcomes on the estimates of cord-serum concentrations of PCB 153 and DDE as continuous variables (per doubling exposure) and as cohort-specific tertiles. Summary estimates were obtained through random-effects meta-analyses.RESULTS: The risk of bronchitis or wheeze (combined variable) assessed before 18 months of age increased with increasing DDE exposure (relative risk [RR] per doubling exposure = 1.03 [95% confidence interval = 1.00-1.07]). When these outcomes were analyzed separately, associations appeared stronger for bronchitis. We also found an association between increasing PCB 153 exposure and bronchitis in this period (RR per doubling exposure = 1.06 [1.01-1.12]) but not between PCB 153 and wheeze. No associations were found between either DDE or PCB 153 and ever-wheeze assessed after 18 months. Inclusion of both compounds in the models attenuated risk estimates for PCB 153 tertiles of exposure, whereas DDE associations were more robust.CONCLUSION: This large meta-analysis suggests that prenatal DDE exposure may be associated with respiratory health symptoms in young children (below 18 months), whereas prenatal PCB 153 levels were not associated with such symptoms.

KW - Adolescent

KW - Adult

KW - Bronchitis

KW - Child, Preschool

KW - Cohort Studies

KW - Dichlorodiphenyl Dichloroethylene

KW - Environmental Exposure

KW - Europe

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Poisson Distribution

KW - Polychlorinated Biphenyls

KW - Pregnancy

KW - Prenatal Exposure Delayed Effects

KW - Respiratory Sounds

KW - Respiratory Tract Diseases

KW - Risk Factors

KW - Young Adult

U2 - 10.1097/ede.0000000000000097

DO - 10.1097/ede.0000000000000097

M3 - Journal article

C2 - 24776790

SN - 1044-3983

VL - 25

SP - 544

EP - 553

JO - Epidemiology

JF - Epidemiology

IS - 4

ER -

Prenatal Exposure to DDE and PCB 153 and Respiratory Health in Early Childhood: A Meta-Analysis

Abstract

Keywords

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